پپتیدهای ضد میکروبی : امیدی تازه در مقابله با گونه های استافیلوکوکوس مقاوم به آنتی بیوتیک های رایج
محورهای موضوعی : میکروبیولوژی
1 - گروه میکروبیولوژی، واحد شهرقدس، دانشگاه آزاد اسلامی، تهران، ایران
کلید واژه: استافیلوکوکوس , مقاومت آنتی بیوتیکی , پپتیدهای ضد میکروبی , بیوفیلم,
چکیده مقاله :
گونه‌هایی از استافیلوکوکوس مانند استافیلوکوکوس اورئوس، استافیلوکوکوس اپیدرمیدیس و استافیلوکوکوس ساپروفیتیکوس از اهمیت بالینی قابل توجهی برای انسان برخوردارند. ایزوله‌های استافیلوکوکوس اورئوس عموماً در برابر بتالاکتام‌های معمولی مقاومت نشان می‌دهند و بسیاری از آنها در برابر پنی‌سیلین‌های مقاوم به بتالاکتاماز نیز مقاومت ایجاد کرده‌اند. علاوه بر این، این سویه‌ها اغلب حامل ژن‌های مقاومتی هستند که ایمنی را در برابر آنتی‌بیوتیک‌های MLS که شامل ماکرولیدها، لینکوزامیدها و استرپتوگرامین‌ها هستند، ایجاد می‌کنند. در دهه 1950، سویه‌های استافیلوکوکوس اورئوس مقاوم به آمینوگلیکوزیدها شروع به ظهور کردند. اخیراً، مقاومت به کینولون‌ها در بین سویه‌های مقاوم به متی‌سیلین از طریق جهش‌های کروموزومی به سرعت افزایش یافته است. پپتیدهای ضدمیکروبی (AMPs) مورد بررسی در این مطالعه از جمله پپتید β دفنسین-1 انسانی ، β دفنسین-3 انسانی، استافیلوکوکسین، لوگدونین، WR12 ، D-IK8 و Tet21 به عنوان یک کلاس جدید امیدوارکننده از آنتی‌بیوتیک‌ها شناخته می‌شوند که در درجه اول به غشای سلولی باکتری آسیب می زنند. مطالعه در مورد AMPها به دلیل نیاز مبرم به عوامل ضدمیکروبی جدید انجام می‌شود. با توجه به مکانیسم عمل آنها که غشای سلولی را هدف قرار می‌دهند، AMPها نویدبخش کاربردهای درمانی هستند. برخی از AMPهای طبیعی نیز ممکن است در برابر این عوامل بیماری‌زا اثربخشی نشان دهند و می‌توانند به طور بالقوه به صورت هم‌افزایی با آنتی‌بیوتیک‌های سنتی مورد استفاده قرار گیرند
Species of Staphylococcus such as S.aureus, S.epidermidis and S.saprophyticus are of significant clinical relevance to humans. Staphylococcus aureus isolates universally exhibit resistance to conventional beta-lactams and many have developed resistance to beta-lactamase-resistant penicillins as well. Additionally, these strains often carry resistance genes that confer immunity to MLS antibiotics, which include macrolides, lincosamides and streptogramins. In the 1950s, strains of Staphylococcus aureus resistant to aminoglycosides began to appear. More recently, resistance to quinolones has rapidly increased among methicillin-resistant strains through chromosomal mutations. The antimicrobial peptides (AMPs) investigated in this study, including human β-defensin-1 peptide, human β-defensin-3, staphylococcin, logdonin, WR12, D-IK8, and Tet21, are recognized as a promising new class of antibiotics that primarily disrupt the bacterial cell membrane.The exploration of AMPs is driven by the critical need for novel antimicrobial agents. Due to their mechanism of action targeting the cell membrane, AMPs hold considerable promise for therapeutic applications. Some naturally occurring AMPs may also demonstrate efficacy against these pathogens and could potentially be used synergistically with traditional antibiotics.
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