اثر هشت هفته تمرین استقامتی فزاینده و مکمل مرزنجوش بر شاخص‌های التهابی در موش‌های صحرایی سالم
محورهای موضوعی : مجله پلاسما و نشانگرهای زیستیصمد امینی فر 1 , محمد نریمانی راد 2 , حمید معین 3
1 - دانشگاه
2 - گروه فیزیولوژی
3 - گروه فیزیولوژی
کلید واژه: تمرین فزاینده, التهاب, آسیب عضلانی, مکمل گیاهی مرزنجوش,
چکیده مقاله :
ز زمینه و هدف: التهاب عضلانی یا میوزیت یک توصیف کلی برای بروز التهابات مزمن و پی شرونده عضلات است. هدف از پژوهش حاضر بررسی اثر هشت هفته تمرین استقامتی فزاینده به همراه مکمل مرزنجوش بر شاخص های التهابی عضلانی در موش های صحرایی سالم بود. روش کار: در این مطالعه 27 سر موش صحرایی حدود دو ماه(250-200 گرم) به صورت تصادفی در سه گروه کنترل، تمرین استقامتی و تمرین استقامتی + مرزنجوش قرار گرفتند. برنامه تمرین استقامتی روی تردمیل به مدت هشت هفته، پنج روز در هفته، بدون شیب و هفته اول تا سوم هر جلسه به مدت 40 دقیقه و در هفته هشتم به مدت 60 دقیقه اجرا شد. مکمل مرزنجوش با استفاده از مخلوط آب به موش های گروه مکمل داده شد. یافته ها بر اساس آمار توصیفی میانگین و انحراف استاندارد و آمار استنباطی تجزیه و تحلیل واریانس یک راهه در سطح معنی داری(05/0=p) با spss تجزیه تحلیل شد. یافته ها: نتایج نشان داد اختلاف معناداری بین سه گروه در میزان TNFα,IL-6, CK وجود دارد. نتایج آزمون تعقیبی توکی نشان داد میزان شاخص های التهابی بعداز فعالیت ورزشی بدون مکمل افزایش معناداری دارد، که در گروه استقامتی + مرزنجوش به طور معنی داری پایین تر از گروه کنترل بود. هم چنین، نتایج نشان داد اختلافی بین گروه تمرین استقامتی و استقامتی با مرزنجوش و گروه کنترل وجود دارد. نتیجه گیری: تمرین استقامتی فزاینده همراه مصرف مرزنجوش احتمالاً به خاطر وجود ترکیبات ضد اکسایشی سبب افزایش ظرفیت تام اکسیدانی و تعادل واکنش های ردوکس در مقابل رادیکال های آزاد تولیدی در اثر فعالیت بدنی شدید می شود.
Background and Aims: Muscle inflammation or myositis is a general description of chronic and progressive inflammation involving muscles. The aim of this study was to investigate the effect of eight weeks of increased training with marjoram supplementation on muscle inflammatory indices in healthy rats. Methods: In this study, 27 rats of about two months (200-250 g) were randomly divided into three groups: control, endurance training and endurance training + marjoram. They got rat were kept in groups of 9 in conditions of free access to water and food. The treadmill endurance training program was performed for eight weeks, five days a week, without slope, and for the first to third week of each session for 40 minutes, and in the eighth week for 60 minutes. Marjoram supplement was given to the rat in the supplement group using a mixture of water. Findings were analyzed spss at the significance level (p = 0.05). Findings: The results showed that there was a significant difference between the three groups in the amount of TNFα, IL-6, CK. The results of Tukey post hoc test showed that the rate of inflammatory markers after exercise without supplementation increased significantly, which was significantly lower in the endurance + marjoram group than the control group. Also, the results showed that there was a difference between the endurance and endurance training groups with marjoram and the control group. Conclusion: Increased endurance training with marjoram consumption probably increases the total oxidative capacity.
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