Electrochemical Synthesis of 5-Aminosalicylic Acid from 5- Nitrosalicylic Acid in Alkaline Media

Subject Areas : Journal of Physical & Theoretical Chemistry

Mohammad Bagher Pasha Zanousi ¹ , Mohammad Saber Tehrani ² , Ardeshir Kermani ³ , Jilla Khalighie ⁴

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Received: 2015-05-03 Accepted : 2015-05-03 Published : 2007-02-01

Keywords: 5-aminosalicylic acid, 5-nitrosalicylic acid, Electrochemical synthesis, elemental analysis, reduction,

Abstract :

5-Aminosalicylic acid (5-ASA) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-NSA) in acidic media. In this work, electrolytic reduction of 5-NSA in alkaline media is presented. Reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the pH for isolation of product are investigated. The yield of the reaction was 90.9%, and themelting point was 280 ° C with decomposition. The UV-Vis and FT-IR spectra of the product was in goodagreement with the standard material. The elemental analysis of the product was almost the same as thestandard.