The effect of an exhausting aerobic exercise session on plasma NT-proBNP and galectine-3 levels in male runners
Subject Areas : Journal of Physical Activity and HormonesSaeed Ilbeigi 1 , Hossein Saeedi 2 , Mohammad Esmaeil Afzalpour 3 , Asghar Haghighi 4 , Maryam Heidarian 5 , Mostafa Haghighi 6 , Masoud Nadrian Jahromi 7
1 - Faculty of Physical Education and Sport Sciences, University of Birjand, Iran
2 - Master of sciences in exercise physiology, Faculty of sport sciences, University of Birjand
3 - Professor in exercise physiology, Faculty of sport sciences, University of Birjand
4 - PhD student in Sport Management, Jahrom University, Iran
5 - PhD student in Exercise Physiology, University of Tabriz, Iran
6 - MS student in Exercise Physiology, University of Birjand, Iran
7 - Department of Sport Management, Jahrom University, Iran
Keywords: Galectin-3, NT-pro BNP, Exhaustive aerobic exercise,
Abstract :
Introduction: Brain natriuretic peptide (BNP) is an indicator released by the effect of increased intra-ventricular pressure and increased volume of ventricular myocarditis. Galectin-3 is a protein produced by the production of myocardial macrophages. The purpose of this study was to investigate the effect of an exhaustive aerobic exercise session on plasma NT-proBNP and galectine-3 levels in male runners. Material & Methods: A total of 12 semi-professional male runners were selected as the subject. The Bruce test protocol was used to achieve the exhaustion. The blood sample was taken before and immediately after the completion of the exhaustive endurance exercise. Results: The results indicated that galectin-3 was increased after the exhaustive endurance exercise (P<0.05); however for NT-pro BNP no significant change was observed. Conclusions: Generally, the acute effect of exhaustive aerobic exercise on cardiac muscle function and the secretion of NT-pro BNP and galectin-3 seem to be different. It seems that galectin-3 has a higher sensitivity. However, more research is needed in this regard.
1. McMurray JJ and Pfeffer MA. Heart failure. Lancet 2005; 365: 1877-89.
2. Maria Sarullo F, Gristina T, Brusca I, Milia S, Raimondi R, Sajeva M, et al. Effect of physical training on exercise capacity, gas exchange and N-terminal pro-brain natriuretic peptide levels in patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil 2006; 13: 812-17.
3. Golshani S, Bagheri B, Ghaemian A, Mokhberi V, Azizi S, Khaninian A, et al. Association of serum N-Terminal pro BNP in the prediction of left ventricular ejection fraction in patients with systolic ventricular dysfunction. J Mazandaran Univ Med Sci 2014, 23: 2-7.
4. Berent R, von Duvillard SP, Crouse SF, Auer J, Green JS, Sinzinger H, et al. Short-term residential cardiac rehabilitation reduces B-type natriuretic peptide. Eur J Cardiovasc Prev Rehabil 2009; 16: 603-608.
5. Maria Sarullo F, Gristina T, Brusca I, Milia S, Raimondi R, Sajeva M, et al. Effect of physical training on exercise capacity, gas exchange and N-terminal pro-brain natriuretic peptide levels in patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil 2006; 13: 812-817.
6. Barondes SH, Cooper DN, Gitt MA and Leffler H. Galectins,Structure and function of a large family of animal lectins. J Biol Chem 1994; 269: 20807-20807.
7. Lok DJA, Van Der Meer P, De la Porte P, Lipsic E, Van Wijngaarden J, et al. Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from the DEAL-HF study. Clin Res Cardiol 2010; 99: 323-328.
8. Hättasch R, Spethmann S, de Boer RA, Ruifrok WP, Schattke S, Wagner M, et al. Galectin-3 increase in endurance athletes. Europ J prevent cardiol 2013; 21: 1192-1199.
9. Salvagno GL, Schena F, Gelati M, Danese E, Cervellin G, Guidi GC, et al. The concentration of high-sensitivity troponin I, galectin-3 and NT-proBNP substantially increase after a 60-km ultramarathon. Clin Chem Lab Med 2014; 52: 267-272.
10. Geny B, Saini J, Mettauer B, Lampert E, Piquard F, Follenius M, et al. Effect of short-term endurance training on exercise capacity, haemodynamics and atrial natriuretic peptide secretion in heart transplant recipients. Europ J Appl Physiol Occupphysiol 1996; 73:259-266.
11. Ahmadizad S, Zahedi Asl S, Sajjadi M, Ibrahim K, Busami M. Effect of twelve weeks of resistance training on resting levels of cardiovascular and related hormones in healthy men, physiol pharmacol 2012; 15: 523-517.
12. Normandin E, Nigam A, Meyer P, Juneau M, Guiraud T, Bosquet L, et al. Acute responses to intermittent and continuous exercise in heart failure patients. Can J Cardiol 2013; 29: 466-471.
13. Bordbar S, Moghadasi M, Babaee Bigi MA, Aslani A, Rahimi E, Ghareh Khani M. Acute and chronic effects of resistance versus endurance training on brain natriuretic peptide level in middle-aged men, J Sport Biom Sci 2013; 5: 42-48.
14. Yurtdaş M, Ozcan IT, Camsar A, Ciçek D, Tamer L, Cin VG, et al. NT-Pro-BNP levels and their response to exercise in patients with slow coronary flow, Arq Bras Cardiol 2012; 99: 1115-1122.
15. de Boer RA, Yu L, van Veldhuisen DJ. Galectin-3 in cardiac remodeling and heart failure. Curr Heart Fail Rep 2010; 7: 1-8.
16. Sharma UC, Pokharel S, van Brakel TJ, van Berlo JH, Cleutjens JP, Schroen B, et al. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation 2004; 110: 3121-3128.
17. Liu YH, D’Ambrosio M, Liao TD, Peng H, Rhaleb NE, Sharma U, et al. N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin. Am J Physiol Heart Circ Physiol 2009; 296: H404-H412.
18. de Boer RA, Edelmann F, Cohen-Solal A, Mamas MA, Maisel A, Pieske B. Galectin-3 in heart failure with preserved ejection fraction. Eur J Heart Fail 2013; 15: 1095-1101.