Cross-linked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as a superior catalyst for the synthesis of oxindoles

Subject Areas : Journal of Nanoanalysis

Hossein Shahbazi-Alavi ¹ , Javad Safaei-Ghomi ²

1 - Young Researchers and Elite Club, Kashan Branch, Islamic Azad University, Kashan, Iran, E-mail addresses: [e-mail] Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Iran
2 - Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Iran

Received: 2019-09-28 Accepted : 2019-09-28 Published : 2019-09-01

Keywords: Isatin, Nanocatalyst, Polyacrylamide, Nano-Fe3O4, Oxindoles,

Abstract :

Cross-linked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as an efficientheterogeneous solid acid catalyst has been used for the preparation of spiro[pyrazoloquinoline-oxindoles]and spiro[chromenopyrazolo-oxindoles] through a four-component reactions of phenylhydrazineor hydrazine hydrate, isatins, ketoesters and naphthylamine or 2-naphthol under reflux conditions inethanol. The remarkable advantages of this methodology are easy work-up, short reaction times, highto excellent product yields, operational simplicity, low catalyst loading and reusability of the catalyst.