Investigation of Physical Effects on Nanoparticle Size in Aerosol Solvent Extraction System
Subject Areas : Journal of Nanoanalysis
1 - Institute of Frontier Material, Yonghyun-Dong, Shanghai, China
2 - Institute of Frontier Material, Yonghyun-Dong, Shanghai, China
Keywords: Acetaminophen, Nano-Particle, supercritical fluid, Anti-solvent,
Abstract :
Aerosol solvent extraction system (ASES) was used to prepare micro-particle of acetaminophen by supercritical carbon dioxide as an anti-solvent. Experiment was carried out at various temperatures, pressures, solvents and investigated the effects of these parameters on particle size, size distribution and morphology by SEM and laser diffraction particle size analyzer. It seems that the choice of solvent is very important for getting specific shape and size of the particle. The temperature and pressure increased with the increase in particle size. After the process, the particle size decreased as 1/20 of the raw material and the morphology was more spherical and regular.