Synthesis of a carbon-14 analogue of N-(aryl-methyl)-3-phenyl-acryl amidine-[carboxy-14C] and its derivatives as NR2B-selective NMDA receptor antagonist

Subject Areas : Journal of the Iranian Chemical Research

Nader Saemian ¹ , Kameh Esmailli ² , Gholamhossein Shirvani ³ , Mohsen Javaheri ⁴ , Omid Khalili Arjomandi ⁵

1 - Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran
2 - Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran
3 - Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran
4 - Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran
5 - Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran

Received: 2010-08-05 Accepted : 2010-09-05 Published : 2010-12-31

Keywords: NMDA-receptor, Carbon-14, Labeling, Amidines,

Abstract :

Four amidine NR2B-selective NMDA receptor antagonists, N-( 2-methoxy benzyl) -3-phenyl-acrylamidine, N-[diduterio(2-methoxyphenyl) methyl]-3-phenyl-acrylamidine, N-benzyl-3-phenyl-acryl amidine and N-[diduterio(phenyl)methyl]-3-phenyl-acrylamidine, all fourlabeled with carbon-14 in the 1-position, have been synthesized as part of 5-step sequence fromBa14CO3.

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