Electropolymerization of 4-aminobenzoic acid containing nano-Au deposited on carbon paste electrode for determination of acetaminophen

Subject Areas : Journal of the Iranian Chemical Research

Yaping Ding ¹ , Ying Zhang ² , Liqiang Luo ³ , Xiao Liu ⁴

1 - Department of Chemistry, Shanghai University, Shanghai, P. R. China
2 - Department of Chemistry, Shanghai University, Shanghai, P. R. China
3 - Department of Chemistry, Shanghai University, Shanghai, P. R. China
4 - Department of Chemistry, Shanghai University, Shanghai, P. R. China

Received: 2012-04-03 Accepted : 2012-08-23 Published : 2012-09-20

Keywords: Acetaminophen, Poly (4-aminobenzoic acid), Nano-Au, Electrocatalysis,

Abstract :

The conducting polymer films have been widely applied in the field of electrochemistry owing to their goodstability, permselectivity, unique physical and chemical properties. A novel nano-Au/poly (4-aminobenzoicacid) (PABA) film modified carbon paste electrode was fabricated for sensitive detection of acetaminophenin this paper. The PABA film and nano-Au/PABA film were characterized by scanning electron microscope.The nano-Au/PABA film exhibited obviously catalytic performance to the determination of acetaminophenwith a high sensitivity and a wide linear range. Under optimum conditions (pH, the concentration of 4-aminobenzoic acid, electro-polymerization cycles), linearity between the oxidation peak current and theacetaminophen concentration was obtained in the range of 1.0 × 10–7 – 8.0 × 10–5 mol L-1 with a detectionlimit of 8.0 × 10–8 mol L-1 (S/N = 3). In addition, the nano-Au/PABA film modified electrode wassuccessfully employed to determine the acetaminophen in commercial drugs, and this work has shed somedoubt on the redox mechanism of acetaminophen at the sensor.

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