Microwave assisted oxidation coupling of thiols to symmetrical disulfides with tripropylammonium fluorochromate (VI) (TPAFC)

Subject Areas : Journal of the Iranian Chemical Research

Mohammad Kazem Mohammadi ¹ , Neda Hasanzadeh ² , Shahriare Ghammamy ³

1 - Islamic Azad University, Ahvaz Branch , Faculty of Science, Ahvaz , Iran
2 - Islamic Azad University, Ahvaz Branch , Faculty of Science, Ahvaz , Iran
3 - Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran

Received: 2010-08-02 Accepted : 2010-09-02 Published : 2010-12-20

Keywords: Oxidation, Microwave irradiation, thiol, Coupling, Disulfide, Tripropylammonium fluorochromate,

Abstract :

Tripropylammonium fluorochromate(VI) (TPAFC), is an efficient and new reagent, which isprepared easily and oxidizes thiols to the corresponding disulfides, quickly. The reactions areperformed cleanly and are controlled to stop at the disulfide stage, without over-oxidation andside products. Coupling of thiols to their corresponding disulfides, are studied in solution atroom temperature and in solution under microwave radiation. The easy procedure, simple workup,short reaction times, and excellent yields, are another advantages of this reagent.

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