SbCl5.SiO2: an reusable lewis acid for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones)

Subject Areas : Journal of the Iranian Chemical Research

Bi Bi Fatemeh Mirjalili ¹ , Esmat Mohammadnejad ² , Abdolhamid Bamoniri ³

1 - Department of Chemistry, College of Science, Yazd University, Yazd, Iran
2 - 1Department of Chemistry, College of Science, Yazd University, Yazd, Iran
3 - Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran

Received: 2011-12-08 Accepted : 2012-05-20 Published : 2012-09-20

Keywords: aldehyde, SbCl5.˙SiO2, Biginelli reaction, 3, 4-dihydropyrimidin-2(1H)-ones, 3, 4 dihydropyrimidin-2(1H)-thiones,

Abstract :

Nano-SbCl5.SiO2 and SbCl5.SiO2 are bench-top catalysts which are reusable, readily available, versatile andefficient for promotion of many acid catalyzed organic reactions. These catalysts do not need specialprecautions for preparation, handling or storage, and they can be stored at an ambient temperature for monthswithout losing their catalytic activity. 4-dihydropyrimidin-2(1H)-ones(thiones) were synthesized in thepresence of Nano-SbCl5.SiO2 or SbCl5.SiO2 as a reusable and efficient catalyst.

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