Boron trifluoride etherate; highly efficient catalyst for synthesis of tert-butylamides via modified Ritter reaction in solvent free condition

Subject Areas : Journal of the Iranian Chemical Research

Masoud Mokhtary ¹ , Faranak Najafizadeh ²

1 - Department of Chemistry, Rasht Branch, Islamic Azad University, PO Box 41325-3516, Rasht, IRAN
2 - Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, PO Box 678, Amol, IRAN

Received: 2011-11-01 Accepted : 2012-03-25 Published : 2012-03-20

Keywords: Modified Ritter reaction, Boron trifluoride etherate, Nitriles, tert-Butylacetate, N- tert- Butyl amides,

Abstract :

Highly efficient method for the preparation of N-tert-butyl amides by reaction of nitriles with tertbutylacetateis described using boron trifluoride etherate in solvent free condition. Selective amidation ofbenzonitrile in the presence of acetonitrile was also achieved.

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