Isolation of borneol and bornyl acetate from Ferulago macrocarpa by microwave irradiation
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)ژیلا اصغری 1 , محمد صالحی 2 , محسن مظاهری تهرانی 3
1 - گروه شیمی، دانشگاه گلستان، گلستان، ایران
2 - گروه شیمی، دانشگاه گلستان، گلستان، ایران
3 - گروه شیمی، دانشگاه گلستان، گلستان، ایران
Keywords: Microwave irradiation, bornyl acetate, Ferulago macrocarpa, Borneol,
Abstract :
Background & Aim: A simple and rapid microwave- assisted extraction (MAE) procedure was developed and optimized for the isolation of borneol and bornyl acetate from Ferulago macrocarpa. Ferulago macrocarpa (Apiaceae) is an endemic plant in Iran. Experimental: Dried powdered aerial parts of plants were soaked in water and irradiated with microwave in a Clevenger extraction approach under optimum conditions (520 W and 0.5 h). Results & Discussion: Compared to traditional heating methods by Clevenger, the present method is more efficiency and proceeds in a short time. The isolation rates of borneol and bornyl acetate increased by about 2 and 1.3, respectively, as compared to the conventional thermal methods. Low cost, easy extraction, high purity of the extracted products and high efficiency are the advantages of this method. Furthermore, solvent free extraction of the essential oils is a good method for the development of green chemistry. Recommended applications/industries: The essential oil of this plant obtained by MAHD and HD methods, contained bornyl acetate as the most abundant component. The extracted essential oil by MAHD was qualitatively similar to that obtained by HD however; it was achieved in a much short time. Therefore pilot microwave reactor might be proven suitable for large scale extraction with potential industrial applications.
Buchbauer, G., Jäger, W., Jirovetz, L., Meyer, F. and Dietrich, H. 1992. Effects of valerian root oil, borneol, isoborneol, bornyl acetate and Isobornyl acetate on the motility of laboratory animals (mice) after inhalation. Pharmazie., 47: 620-622.
Chun-Jie W., Qin-wan H., Hong-yI Q., Ping G. and Shi-xiang, H. 2006. Promoting effect of borneol on the permeability of puerarin eye drops and timolol maleate eye drops through the cornea in vitro. Pharmazie., 61: 783-788.
Clark, A.M. 1996. Natural products as a resource for new drugs. Pharmaceutical Research., 13: 1133-1144.
Djouahri, A., Boudarene, L. and Meklati, E.Y., 2013. Effect of extraction method on chemical composition, antioxidant and anti-inflammatory activities of essential oil from the leaves of Algerian Tetraclinis articulata (Vahl) Masters. Industrial Crops and Products., 44: 32-36.
Ganzler K., Bati J. and Valko K., 1990.Effective sample preparation method for extracting biologically active compounds from different matrices by a microwave technique. Journal of Chromatography A., 520: 257-262.
Hadjiakhoondi A., Aghe L.N. and Etemadi R.. 1992. Chemical and biological study of essential oil of Ferulago macrocarpa (Fenzi) Boiss, Effects of valerian root oil, borneol, isoborneol, bornyl acetate and isobornyl acetate on the motility of laboratory animals (mice) after inhalation, Publisher: Bait al-Hikmah., 620-622.
Heywood, V.H. 1985. Flowering Plants of the Word, Croom Helm. London 219-221.
Hao, J., Han, W., Huang, S., Xue, B. and Deng, X. 2002. Microwave- assisted extraction of artemisinin from Artemisia annua L. Separation and Purification Technology.,., 28: 191-196.
Kaufmann, B. and Christen, P. 2002. Recent extraction techniques for natural products: microwave-assisted extraction and pressurised solvent extraction. Phytochemistry Analysis., 13: 105–113.
Lucchesi, M.E., Chemat, F. and Smadja, J. 2004. Solvent- free microwave extraction of essential oil from aromatic herbs: comparison with conventional hydro-distillation. Journal of Chromatography A., 1043: 323- 327.
Lucchesi, M.E., Smadja, J., Bradshaw, S. Louw, W. and Chemat, F. 2007. Solvent free microwave extraction of Elletaria cardamomum L.: A multivariate study of a new technique for the extraction of essential oil. Journal of Food Engineering., 79: 1079-1086.
Meirong, L., Shaomei, Y., Yingqing, Z., Weiping, Q. and Meirong, F. 1993. The effect of borneol on evan's blue staining of rabbit and rat brain tissue. Institute of Clinical Pharmacology. 4.
Mohamed, A., Ferhat, A., Brahim, Y., Meklati, A., Jacqueline, Smadja B. and Farid Hemat, C. 2006. An improved microwave Clevenger apparatus for distillation of essential oils from orange peel. Journal of Chromatography A., 1112: 121–12.
Mozaffarian, V.1994.Plant Systematics, Vol. 2, Nashr Danesh Emrouz, Tehran 372.
Mozaffarian, V. 1996. A Dictionary of Iranian Plant Names, Farhang Moaser, Tehran 194-195.
Mozaffarian, V. 1983. The family of Umbelliferae in Iran, Key and distribution, Research Institute of Forests and Rangelands, Tehran, Iran, 35, 387.
Wang, Z., Ding, L., Li, T., Zhoua, X., Wanga, L. and Zhang, H. 2006 Improved solvent-free microwave extraction of essential oil from dried Cuminum cyminum L. and Zanthoxylum bungeanum Maxim. Journal of Chromatography A., 1102: 11–17.
Xiao-Jing, H., Qing-jie, L. and Yu-lan, L. 2006. Effects of Borneol injection on inflammation in focal cerebral ischemia reperfusion rats. West China Journal of Pharmaceutical Sciences, 21:523-526.
Xue, L., Chen, X.W., Fan, H.X., Fan, Sh., Liang, Y., Xia, J.X., Zhou, H. and Hu, Zh. 2006. Effect of borneol on levels of monoamine neurotransmitters in prefrontal cortex of rat after long-term continuous operations, Acta Academiae Medicinae Militaris Tertiae, 18.