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Manuscript ID : 688557 Visit : 220 Page: 725 - 732

10.22034/jchr.2022.688557

Article Type: Original Research

Preparation, Characterization and Antibacterial Activity of some New Oxazolidin-5-one Derivatives Derived from Imine Compounds

Subject Areas : Journal of Chemical Health Risks

Rasim Farraj Muslim 1 , Ismaeel Majeed 2 , Suheb Eaid Saleh 3 , Marwan Mahmood Saleh 4 , Mustafa Nadhim Owaid 5 , Jalal Abdulkareem Abbas 6

1 - Department of Environmental Sciences, College of Applied Sciences-Hit, University of Anbar, Hit, Anbar, Iraq
2 - Department of chemistry, College of education for pure science-Ibn Al-Haitham University of Baghdad, Baghdad, Iraq
3 - Directorate of Education in Anbar, Ministry of Education, Ramadi, Anbar 31001, Iraq
4 - Department of Biophysics, College of Applied Sciences-Hit, University of Anbar, Hit, Anbar, Iraq
5 - Department of Heet Education, Directorate of Education in Anbar, Ministry of Education, Hit, Anbar, Iraq
6 - Department of Chemistry, Faculty of Science, Gazi University, Teknikokullar, Ankara, Turkey

Received: 2021-09-25 Accepted : 2021-11-27 Published : 2022-12-01

Keywords: Biological activity, Heterocyclic, Oxazolidine-5-one, MICs,

Abstract :

In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J1-J5 derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. By combining primary aromatic amines and aromatic carbonyl compounds, Schiff's bases were synthesized. Schiff bases are used with the chloroacetic acid compound to prepare oxazolidine-5-one J1-J5 derivatives. The compounds J1-J5 were described using NMR spectroscopy and FT-IR. .The biological efficacy was evaluated according to maximum inhibitory concentrations (MICs) toward Staphyloccoccus aureus and Esherichia coli. The best MIC was 210 μg ml-1 for J4 against the two pathogenic bacteria, while J1, J4, and J1 did not show any inhibitory effect against all bacteria. Finally, the best chemical created, 3'-(pyrimidin-2-yl) spiro[indoline-3,2'-oxazolidine]-2,5'-dione (J4), inhibited the development of both gram-negative and positive bacteria.

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