Synthesis, Characterization, and Computational, Biological Studies of Four-membered Cyclic Amides 2- azetinones

Subject Areas : Journal of Chemical Health Risks

Auhood Kadhim Zaid ¹

1 - Department of Chemistry, College of Science, University of Thi-Qar, Iraq

Received: 2021-06-04 Accepted : 2021-09-15 Published : 2022-12-01

Keywords: β-Lactams, Azetidin-2-ones, Tetrahydro furan-3-carboxylic acid, Gaussian program,

Abstract :

Two compounds,3-benzoyl-2-(4-bromophenyl)-3-phenyl-6 – oxa-2-azaspiro[3.4]octan-1-one and 1',1'''-bis(3-bromo-4-(dimethylamino)phenyl)-4,4'''',5,5''''-tetrahydro-2H,2''''H-tetraspiro[furan-3,2'-azetidine-4',1''-acenaphthylene-2'',2'''-azetidine-3''',3''''-furan]-3',4'''-dione, were synthesized by tetrahydro furan-3-carboxylic acid and appropriate imines. Two studies were conducted on the prepared compounds, one of them is the study of their anti-biological efficacy using two types of bacteria Staphylococcus aureus and Escherichia coli, The other study that was conducted on the compounds is a computational study to calculate some of the thermodynamic parameters of synthesized derivatives by using a Gaussian program.

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