اثربخشی کاربرد موضعی کارواکرول، آمیتراز و ترکیب کارواکرول آمیتراز در درمان سگ‌های مبتلا به دمودیکوزیس عمومیت یافته
محورهای موضوعی : انگل شناسی
سینا فریدونی
1
(گروه علوم درمانگاهی، دانشکده علوم تخصصی دامپزشکی، واحد علوم و تحقیقات ، دانشگاه آزاد اسلامی، تهران ، ایران)
فرنوش ارفعی
2
(گروه علوم درمانگاهی، دانشکده علوم تخصصی دامپزشکی، واحد علوم و تحقیقات ، دانشگاه آزاد اسلامی، تهران ، ایران)
محمد رضا یوسفی
3
(بخش انگل شناسی، دانشکده دامپزشکی، واحد بابل ، دانشگاه آزاد اسلامی، بابل ، ایران)
فاطمه زهرا غریب
4
(گروه علوم درمانگاهی، دانشکده دامپزشکی، واحد بابل ، دانشگاه آزاد اسلامی، بابل ، ایران)
محدثه ابوحسینی طبری
5
(دانشکده دامپزشکی، دانشگاه تخصصی فنآوری های مدرن، آمل ، ایران )
کلید واژه: دمودیکوزیس, کارواکرول, آمیتراز, پوست, ریختنی,
چکیده مقاله :
دمودیکوزیس سگ یک بیماری پوستی انگلی التهابی است که با افزایش جمعیت گونه‌های جرب دمودکس ایجاد می‌شود. بنابراین، نیاز فوری به درمان موثر، ایمن و در دسترس برای دمودیکوزیس وجود خواهد داشت. این مطالعه با هدف ارزیابی فعالیت کارواکرول 5 درصد، آمیتراز 05/0 درصد و ترکیب کارواکرول- آمیتراز در کشتن جرب های دمودکس کنیس پس از استفاده موضعی و تجزیه و تحلیل بهبود علائم پوستی مرتبط انجام شد. 15 سگ مبتلا به دمودیکوز عمومیت یافته اکتسابی طبیعی به طور تصادفی به 3 گروه مطالعه مساوی تقسیم شدند. سگ ها از پناهگاه حیوانات استان مازندران انتخاب شدند. گروه های درمانی شامل محلول ریختنی 50 میلی لیتر کارواکرول 5 درصد، 50 میلی لیتر آمیتراز 05/0 درصد و مخلوط کارواکرول و آمیتراز 1:1 در غلظت های یکسان بودند. ارزیابی فاکتورهای بالینی شامل شمارش کنه شامل تراشیدن پوست، رشد مجدد مو، جوش های زیرپوستی، قرمزی، میزان کبره بستن و پوسته ریزی در فواصل هفت روزه در چهار هفته بود. تعداد جرب ها در تمام گروه ها به ویژه در کارواکرول 5 درصد به طور معنی داری کاهش یافت (05/0>p). تفاوت معنی داری بین آمیتراز و کارواکرول آمیتراز در روزهای 14، 21 و 28 وجود نداشت (05/0<p). بیشترین کاهش جمعیت جرب با کارواکرول 5 درصد از روز 14 تا 90 درصد در تیمار دمودیکوزیس همراه بود. این مطالعه میدانی بالینی نشان داد که تجویز کارواکرول 5% به صورت تزریقی در کاهش تعداد جرب و بهبود علائم پوستی مرتبط با دمودیکوزیس بسیار موثر است.
Canine demodicosis is an inflammatory parasitic skin disease caused by an increasing population of Demodex spp. mite. Thus, there will be an urgent need for effective, safe, and available treatment for demodicosis. This study aimed to evaluate the activity of Carvacrol %5, Amitraz %0.05, and Carvacrol-Amitraz combination on killing Demodex canis mites after topical pour-on use and analyzing the improvement in associated dermatologic signs. Fifteen dogs with naturally acquired generalized demodicosis were randomly allocated to 3 equal study groups. The dogs were selected from the animal shelter in Mazandaran province. Treatment groups included a pour-on solution of 50 ml of Carvacrol %5, 50 ml of Amitraz %0.05, and the combined Carvacrol and Amitraz 1:1 mixture at the same concentrations. Evaluation of clinical factors consisted of mite count by skin scraping, hair re-growth, comedones, erythema, crusts, and scales during seven-day intervals over four weeks. Mite counts significantly decreased in all groups during the study, especially in Carvacrol %5 (p0.05). The highest decrease in mite population was associated with Carvacrol %5 from day 14 up to %90 in demodicosis treatment. This clinical field study demonstrated that pour-on administration of Carvacrol %5 is highly effective in the reduction of mite numbers and improvement in associated dermatologic signs of demodicosis
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