An Efficient and One-pot Procedure for the Synthesis of Chiral Isoxazolidine via Catalytic Highly Enantioselective 1,3-dipolar cycloaddition

Taghizadeh, Mohammad Javad

Manuscript ID : 523906 Visit : 200 Page: 133 - 141

20.1001.1.20083815.2016.10.2.12.8

Article Type: Original Research

An Efficient and One-pot Procedure for the Synthesis of Chiral Isoxazolidine via Catalytic Highly Enantioselective 1,3-dipolar cycloaddition

Subject Areas : Polymer

Mohammad Javad Taghizadeh ¹

1 -

Received: 2016-07-22 Accepted : 2016-07-22 Published : 2016-05-01

Keywords:

Abstract :

Synthesis of enantiomerically pure isoxazolidine via an asymmetric 1,3- dipolar cycloaddition reaction of nitrone with electron-deficient dipolarophile was described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendate bis(imine)–Cu(II)triflate complex as catalyst. The reaction mechanism is discussed on the basis of the assignment of the absolute configuration of the cycloadducts.

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A DFT and Molecular Dynamics Study on Inhibitory Action of Three Amine Derivatives on Corrosion of Carbon Steel
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An Efficient and One-pot Procedure for the Synthesis of Chiral Isoxazolidine via Catalytic Highly Enantioselective 1,3-dipolar cycloaddition