Preparation and Characterization of Magnetic Gelatin-Polyvinyl Alcohol Hydrogel for using in the Release of Furosemide Drug

Subject Areas : Polymer

Benyamin Masoumi ¹ , Masoud Mokhtary ²

1 - Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran
2 - Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran

Received: 2022-12-06 Accepted : 2022-12-06 Published : 2023-01-01

Keywords:

Abstract :

The magnetic gelatin-polyvinylalcohol hydrogel was prepared using K2S2O8 in aqueous media inthe presence of N,N′-methylenebisacrylamide, and Fe3O4 nanoparticles. The magnetic gelatinpolyvinylalcohol (Fe3O4/PVA-gelatin) hydrogel was characterized by FT-IR, SEM, and EDX. Also,magnetic characterization of the synthesized Fe3O4/PVA-gelatin hydrogel was specified by avibrating sample magnetometer (VSM). Then, the loading and release of the furosemide drug wereinvestigated using magnetic gelatin-polyvinylalcohol hydrogel. The FT-IR results confirmed theformation of gelatin-polyvinyl alcohol magnetic hydrogel. The effects of temperature and pH on theloading and release of furosemide drug in gelatin-polyvinylalcohol magnetic hydrogel were studied.The gelatin-PVA magnetic hydrogel is sensitive to pH and temperature and provides the controlledrelease of furosemide. The results showed that the highest loading of the drug was achieved at roomtemperature after 6 hours. Also, the highest drug release was observed after 4 hours at 40 °C in pH= 7.

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