One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar

Subject Areas :

1 - Department of Chemistry , Shahid Chamran University , Ahwaz , Iran
2 - Department of Chemistry , Shahid Chamran University , Ahwaz , Iran

Received: 2016-06-01 Accepted : 2016-06-01 Published : 2012-05-01

Keywords: Green Chemistry, Synthesis, solvent free, Phenytoin, Grinding,

Abstract :

phenytoine derivatives were synthesized , via the pinacol condensation with the reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea in presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle at room temperatures. The reaction was completed at short reaction times (approximately 15min) and pure products were obtained with high yields (81-94%).

References:

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One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar