Synthesis of imidazo[2,1-b]thiazole-3-carboxylate through the reaction of thiohydantoins and ethylbromopyruvate

Subject Areas :

Nasimeh Zarei ¹ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Mohammad Mehdi Ghanbari ² (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Marzieh Jamali ³ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Mahboobeh Kiamarsi ⁴ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Pegah Mohagheghzadeh ⁵ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)

Received: 2016-05-29 Accepted : 2016-05-29 Published : 2011-05-01

Keywords: Thiohydantoin, Imidazo[2, 1-b]thiazole, Ethylbromopyruvate, anticancer, Thioxoimidazolidin,

Abstract :

Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions