Efficient Synthesis of Thiazolo[4,5-d]pyrimidine derivatives without solvent

Subject Areas :

1 - Department of Chemistry, School of Sciences, Ahvaz Branch, Islamic Azad University, Iran

Received: 2019-02-08 Accepted : 2019-05-23 Published : 2019-08-01

Keywords: pyrimidine, thiazolo[4, 5-d]pyrimidine, 5-Bromo-2, 4-dichloro-6-methylpyrimidine, 4-Amino-5-bromo-2-substituted-aminopyrimidines,

Abstract :

4-Amino-5-bromo-2-substituted-aminopyrimidines were successfully reacted with various isothiocyanates in the alkaline alumina under Microwave irradiation to achieve a group of reported 2- aminothiazolo[4,5-d]pyrimidine derivatives . These compounds also carried out a multicomponent condensation with carbondisulfid and alkylhalides to furnish a group of reported 2- alkylsulfanylthiazolo[4,5-d]pyrimidine derivatives.

References:

Synthesis and spectroscopic study of a new diamidophosphoester, (4-CH3-C6H4O)((CH3)2CHNH)2P(O)
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One-pot synthesis of 1,2,4,5-tetrasubstituted Imidazoles using BiFeO3
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Tributyl hexadecyl phosphonium bromide as a new and efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidinones/thiones via a three component condensation reactions
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Theoretical study of HCX (NH2) (X= O, S, and Se) analogs in the gas phase: Electronic Structure, Natural Bond Orbital (NBO) & Natural Resonance Theory (NRT)
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Synthesis 3 and 4-Dihydropyrimidinone and Thiones using Multi-Walled Carboxylated Carbon Nanotube Catalysts
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Study of the effects of solvent and temperature on the Connections of the MTX and L-FMTX with single-walled carbon nanotubes using QM and MM
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Efficient Synthesis of Thiazolo[4,5-d]pyrimidine derivatives without solvent