Dihydropyrimidinonoes Synthesis via One Pot Solvent-free Cu catalyzed Reaction
Subject Areas :
1 - Department of Chemistry, Ahvaz Branch,Islamic Azad University, Ahvaz, IRAN
Keywords: Biginelli, Dihydropyrimidinones, One-pot, Solvent-free, CuCl2 ,
Abstract :
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An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol. we now wish to report a facile and rapid one-pot solvent free three component procedure preparation of DHPMs derivatives with CuCl2 as a non-toxic, reusable, inexpensive and easily available reagent, under solvent-free conditions at the range of temperatures. |
we now wish to report a facile and rapid one-pot solvent free three component procedure preparation of DHPMs derivatives with CuCl2 as a non-toxic, reusable, inexpensive and easily available reagent, under solvent-free conditions at the range of temperatures.
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