Investigation of the Nonlinear Refractive Index of MCF7 and MCF10A Breast Cell Lines for Optical Diagnosis

Subject Areas : Photon Therapy, Diagnosis and Equipment

Bahareh Khaksar Jalali ¹ , Somayeh Salmani Shik ² , Latifeh Karimzadeh Bardee ³ , sharifeh shahi ⁴

1 - 1. Department of physics, Kharazmi University, Tehran, Iran. 2. Laser and Biophotonics in Biotechnologies Research Center, Islamic Azad University of Isfahan (Khorasgan) branch, Isfahan, Iran.
2 - 1. Department of physics, Kharazmi University, Tehran, Iran. 2. Applied Sciences Research Center, Kharazmi University, Karaj, Iran.
3 - Department of animal biology, Faculty of biological sciences, kharazmi university, Tehran, Iran.
4 - 1. Department of Biomedical Engineering, Islamic Azad University of Isfahan (Khorasgan) branch, Isfahan, Iran. 2. Laser and Biophotonics in Biotechnologies Research Center, Islamic Azad University of Isfahan (Khorasgan) branch, Isfahan, Iran.

Received: 2022-10-12 Accepted : 2023-01-31 Published : 2022-10-01

Keywords: MCF7, Z-scan technique, Cancer Diagnosis, Linear Absorption, MCF10A, Optical Coefficients,

Abstract :

To demonstrate that the Z-scan technique is a reliable approach for diagnosing normal and cancer cells, the absorption coefficient (α), nonlinear refractive index (n2) of normal (MCF10A) and cancer cell lines (MCF7) were examined. According to our findings of the optical properties of cells, cancer cells shown to have higher linear absorption coefficient than normal cells as well as nonlinear refractive index (n2) of different signs but the same order of (10-7 cm2/W). This method is a quick method for differentiating between normal and cancerous breast cells, making it suitable for use in clinical stages in the future. This is because of the obvious fundamental difference between the optical behavior of normal and cancer cells, as well as the affordability, the potential for reproducibility without compromising sample quality, and the high accuracy.