Optical biosensor for detection of hemoglobin using ternary photonic crystals

Subject Areas : Optical Biosensors

Minoo Aghamohammadian ^{1 *} , Ali Vahedi ² , Siyamak Haghipour ³

1 - Department of Biomedical Engineering, Tabriz Branch , Islamic Azad University , Tabriz , Iran
2 - Department of physics, Tabriz Branch,Islamic Azad University, Tabriz, Iran
3 - Department of Biomedical Engineering, Tabriz Branch , Islamic Azad University , Tabriz , Iran

Received: 2024-12-13 Accepted : 2025-05-28 Published : 2025-09-06

Keywords: Hemoglobin , Photonic Crystal, Transfer Matrix Method, Optical Biosensor,

Abstract :

Optical biosensors have attracted the attention of researchers because they have a unique ability to control the dispersal of photons and detect the natural shape of biomolecules. The main component of blood is hemoglobin, whose main function is to transport oxygen to body tissues and remove carbon dioxide from them. This article aims to simulate biosensors that can detect hemoglobin concentration using photonic crystals. For this purpose, we have used two structures with TiN/m/Ti  and Al_XGa_1-XN structural dielectrics, which have different refractive indices and can control light transmittance. Photonic crystals have a region called the photonic band gap (PBG), in which waves cannot propagate in the structure. layers inside the photonic crystal structure controlled and adjusted the defect modes and PBG properties. To find the best result, parameters such as the layer thickness, the light incident angle and the refractive index have been optimally selected. After examining the proposed structures, it was determined that both of structures are more optimal in wide defect layer. The results show that the TiN/m/Al_XGa_1-XN structure has narrow, maximum intensity detection modes and a broader bandgap at the selected wavelength range compared to the other structure.

References:

1. John, S., Localization of light: Theory of photonic band gap materials, in Photonic band gap materials. 1996, Springer. p. 563-665.
2. CM, B., Development and application of materials exhibiting photonic band gaps. J. Opt. Soc. Am. B, 1993. 10(2): p. 280-413.
3. John, S., H. Sompolinsky, and M.J. Stephen, Localization in a disordered elastic medium near two dimensions. Physical Review B, 1983. 27(9): p. 5592.
4. Ďuriška, L., et al., Aqueous corrosion of aluminum-transition metal alloys composed of structurally complex phases: A review. Materials, 2021. 14(18): p. 5418.
5. Ghasemi, F. and S. Razi, Novel photonic bio-chip sensor based on strained graphene sheets for blood cell sorting. Molecules, 2021. 26(18): p. 5585.
6. Kong, W., et al., Wavelength manipulation in a grating metasurface loaded Bloch surface wave structure. Results in Physics, 2021. 27: p. 104496.
7. Firouzi, F., A. Vahedi, and S. Hagipour, Ternary one-dimensional photonic crystal biosensors for efficient bacteria detection: Role of quantum dots and material combinations. Physica B: Condensed Matter, 2025. 698: p. 416766.
8. Daher, M.G., et al., Design of a novel optical sensor for the detection of waterborne bacteria based on a photonic crystal with an ultra-high sensitivity. Optical and Quantum Electronics, 2022. 54(2): p. 108.
9. Taya, S.A., et al., Highly sensitive nano-sensor based on a binary photonic crystal for the detection of mycobacterium tuberculosis bacteria. Journal of Materials Science: Materials in Electronics, 2021. 32: p. 28406-28416.
10. Mohamed, A.M., et al., Design of a 1D PhC biosensor with enhanced sensitivity based on useful features provided for the detection of waterborne bacteria. Optical and Quantum Electronics, 2024. 56(3): p. 433.
11. Aly, A.H., et al., MATLAB simulation based study on poliovirus sensing through one-dimensional photonic crystal with defect. Scientific Reports, 2023. 13(1): p. 9422.
12. Meradi, K.A., et al., Optical biosensor based on enhanced surface plasmon resonance: theoretical optimization. Optical and Quantum Electronics, 2022. 54(2): p. 124.
13. Malek, C., et al., High performance biosensor composed of 1D defective photonic crystal for sensing and detection of distinguished blood components. Optical and Quantum Electronics, 2023. 55(3): p. 196.
14. Qu, W., et al., Application of Optical Fiber Sensing Technology and Coating Technology in Blood Component Detection and Monitoring. Coatings, 2024. 14(2): p. 173.
15. Su, M., et al., Tamm-plasmon-polariton biosensor based on one-dimensional topological photonic crystal. Results in Physics, 2023. 48: p. 106454.
16. El-Khozondar, H.J., et al., Design of one dimensional refractive index sensor using 40
ternary photonic crystal waveguide for plasma blood samples applications. Physica E: Low-dimensional Systems and Nanostructures, 2019. 111: p. 29-36.
17. Goyal, A.K. and S. Pal, Design analysis of Bloch surface wave based sensor for haemoglobin concentration measurement. Applied Nanoscience, 2020. 10: p. 3639-3647.
18. Hao, J.-J., et al., Research on low-temperature blood tissues detection biosensor based on one-dimensional superconducting photonic crystal. Communications in Nonlinear Science and Numerical Simulation, 2020. 89: p. 105299.
19. Goyal, A.K., Design analysis of one-dimensional photonic crystal based structure for hemoglobin concentration measurement. Progress In Electromagnetics Research M, 2020. 97: p. 77-86.
20. Abadla, M.M. and H.A. Elsayed, Detection and sensing of hemoglobin using one-dimensional binary photonic crystals comprising a defect layer. Applied optics, 2020. 59(2): p. 418-424.
21. Abohassan, K.M. and H.S. Ashour, Demultiplexers for DWDM applications using one-dimensional planar binary photonic crystals defected with ZnS x Se1-x ternary alloys. Journal of Nanophotonics, 2022. 16(1): p. 016006-016006.
22. Abohassan, K.M., H.S. Ashour, and M.M. Abadla, A 1D binary photonic crystal sensor for detecting fat concentrations in commercial milk. RSC Advances, 2021. 11(20): p. 12058-12065.
23. Yashaswini, P.R., et al., Design and simulation of a highly sensitive one-dimensional photonic crystal for different chemical sensing applications. Results in Optics, 2023. 11: p. 100376.
24. Ashour, H.S., K.M. Abohassan, and M.M. Abadla, Defective 1D quinary photonic crystal sensors for the detection of cancerous blood cells. Optical Engineering, 2021. 60: p. 127106 - 127106.
25. Al-Dossari, M., et al., Bio-Alcohol Sensor Based on One-Dimensional Photonic Crystals for Detection of Organic Materials in Wastewater. Materials, 2022. 15(11): p. 4012.
26. Kuliešaitė, M., et al., Partially coherent UV–VIS light generation in photonic crystal fiber using femtosecond pulses. Results in Physics, 2021. 31: p. 104965.
27. Mostafa, T., A. Ahmed, and E.-S. El-Rabie, Photonic crystal analog to digital converter a literature review, challenges, and some novel trends. Menoufia Journal of Electronic Engineering Research, 2022. 31(2): p. 64-74.
28. Rao, D.G.S., S. Swarnakar, and S. Kumar, Design of photonic crystal based compact all-optical 2× 1 multiplexer for optical processing devices. Microelectronics Journal, 2021. 112: p. 105046.
29. Zaky, Z.A. and A.H. Aly, Gyroidal graphene/porous silicon array for exciting optical Tamm state as optical sensor. Scientific Reports, 2021. 11(1): p. 19389.
30. Mohammed, N.A., et al., Tuberculosis biomedical sensor based on on-chip nanocavity 2D photonic crystal with high sensitivity and quality factor. Measurement, 2023. 222: p. 113595.
31. Patel, S.K., et al., Design of graphene metasurface based sensitive infrared biosensor. Sensors and Actuators A: Physical, 2020. 301: p. 111767.
32. Ramanujam, N., et al., Design of one dimensional defect based photonic crystal by composited superconducting material for bio sensing applications. Physica B: Condensed Matter, 2019. 572: p. 42-55.
33. White, I.M. and X. Fan, On the performance quantification of resonant refractive index sensors. Optics express, 2008. 16(2): p. 1020-1028.
34. Marmarou, A., et al. In vivo measurement of brain water by MRI. in Brain Edema VIII: Proceedings of the Eighth International Symposium, Bern, June 17–20, 1990. 1990. Springer.
35. Del Villar, I., et al., Nano-Photonic Crystal D-Shaped Fiber Devices for Label-Free Biosensing at the Attomolar Limit of Detection. Adv Sci (Weinh), 2024. 11(35): p. e2310118.
36. Shaban, M., et al., Tunability and sensing properties of plasmonic/1D photonic crystal. Scientific reports, 2017. 7(1): p. 41983.
37. Panda, A. and P.D. Pukhrambam, Investigation of defect based 1D photonic crystal structure for real-time detection of waterborne bacteria. Physica B: Condensed Matter, 2021. 607: p. 412854.
38. Wang, P., et al., MXene/metal–organic framework based composite coating with photothermal self-healing performances for antifouling application. Chemical Engineering Journal, 2023. 474: p. 145835.
39. Chakaya, J., et al., The WHO Global Tuberculosis 2021 Report–not so good news and turning the tide back to End TB. International Journal of Infectious Diseases, 2022. 124: p. S26-S29.
40. Aly, A.H., et al., Novel biosensor detection of tuberculosis based on photonic band gap materials. Materials Research, 2021. 24: p. e20200483.
41. Altug, H., et al., Advances and applications of nanophotonic biosensors. Nature nanotechnology, 2022. 17(1): p. 5-16.
42. Lazareva, E.N. and V.V. Tuchin, Measurement of refractive index of hemoglobin in the visible/NIR spectral range. Journal of biomedical optics, 2018. 23(3): p. 035004-035004.