پیشرفت‌های اخیر فناوری زیستی در تهیه پانسمان‌های زخم برای افراد دیابتی

محورهای موضوعی : فصلنامه زیست شناسی جانوری

سید رسول ذاکر ¹ , سیده شهربانو جعفری ² , رحمان امام زاده ³

1 - مرکز پژوهشی فرآورده های طبیعی و زیستی دارویی، دانشگاه اصفهان، اصفهان، ایران
2 - گروه زیست شناسی، دانشکده علوم و فناوری های زیستی، دانشگاه اصفهان، اصفهان، ایران
3 - گروه زیست شناسی، دانشکده علوم و فناوری های زیستی، دانشگاه اصفهان، اصفهان، ایران

تاریخ دریافت : 1402/01/25 تاریخ پذیرش : 1402/03/12 تاریخ انتشار : 1402/12/01

کلید واژه: پانسمان زخم پیشرفته, پلیمرهای طبیعی, سیتم تحویل دارویی, فناوری زیستی‌, زخم پای دیابتی,

چکیده مقاله :

دردو دهه اخیر با توجه به اهمیت داروهای حاصل از فناوری زیستی‌ و نقش مهم آن‌ها در درمان زخم‌های مزمن، مطالعات پیش‌بینی کرده‌اند که بازار مراقبت از زخم پیشرفته خصوصا زخم‌های جراحی و زخم‌های مزمن احتمالاً تا سال 2024 به 15 تا 22 میلیارد دلار خواهد رسید. بنابراین در مطالعه حاضر پیشرفت‌های اخیر فناوری زیستی در زمینه‌ی تهیه پانسمان زخم از ترکیبات حاصل از گیاهان و جانوران برای افراد مبتلا به زخم پای دیابتی بحث شده است. در این تحقیق روش‌ها و رویکردهای تحویل عوامل درمانی برای درمان DFUs و در واقع نتایج اخیر مطالعات برون تنی و درون تنی، با تأکید بر پتانسیل منحصربه‌ فرد پانسمان‌های زخم مبتنی بر پلیمرهای طبیعی در درمان DFUs، جمع آوری و مورد بررسی قرار گرفته است. مروری بر چالش‌های پیش‌رو در درمان زخم‌های مزمن، ناکافی بودن اثربخشی برخی از محصولات مراقبت از زخم را نشان می‌دهد که بیانگر این است که خانواده‌ها و دولت باید با چالش‌های پزشکی برای دوره‌های طولانی‌تری مبارزه کنند. زخم پای دیابت نوعی زخم مزمن است که می‌تواند باعث عفونت‌های شدید و حتی قطع عضو شود. مواد زیستی که در حال حاضر به عنوان ماتریکس برای ترمیم زخم استفاده می‌شوند را می‌توان با توجه به منشاء آنها به انواع طبیعی و مصنوعی طبقه‌بندی کرد. با توجه به ویژگی‌های تخریب آسان، زیست سازگاری قابل توجه، کاهش پاسخ‌های التهابی و ماهیت غیر ایمنی‌زا، مواد زیستی طبیعی مانند، کیتوزان، الژینات، سلولز، اسید هیالورونیک، فیبروئین ابریشم، کلاژن به طور گسترده‌ای برای ترمیم زخم پای دیابتی توصیه شده است.

چکیده انگلیسی:

In the last two decades, given the importance of biotechnological drugs and their important role in the treatment of chronic wounds, studies have predicted that the market for advanced wound care targeting surgical wounds and chronic wounds is likely to reach $15-22 billion by 2024. Therefore, in the present study, the recent advances in biotechnology in the field of preparing wound dressings from compounds obtained from plants and animals for people with diabetic foot ulcers have been discussed. In this research, the methods and approaches of delivery of therapeutic agents for the treatment of DFUs and in fact the recent results of in vitro and in vivo studies, emphasizing the unique potential of wound dressings based on natural polymers in the treatment of DFUs, have been collected and analyzed. This expansion is expected to be driven by advances in technology, increased incidence of chronic wounds, and an increasing elderly population. A review of the challenges ahead in the treatment of chronic wounds reveals the inadequacy of the effectiveness of some wound care products, suggesting that families and governments must contend with medical challenges for longer periods. Diabetic foot ulcer (DFIU) is a chronic ulcer that can cause severe infections and even amputation. Biomaterials that are currently used as matrices for wound healing can be classified into natural and synthetic types according to their origin. Natural biomaterials such as chitosan, alginate, cellulose, hyaluronic acid, silk fibroin, and collagen have been widely recommended for diabetic foot wound healing due to their easy degradability, remarkable biocompatibility, reduced inflammatory responses, and non-immunogenic nature. Biotechnology guarantees the possibility of using natural biomaterials to develop advanced wound dressings with appropriate and patient-friendly therapeutic results. 

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