زمینه و هدف: یکی از عوارض مرتبط با سالمندی کاهش حجم عضلانی است که نقص در مسیرهای سلولی مانند اتوفاژی در تنظیم آن نقش دارد؛ فعالیت‌های ورزشی می‌تواند یک عامل کلیدی در معکوس یا افزایش این عارضه باشد؛ بنابراین هدف از انجام تحقیق حاضر تاثیر تمرین تناوبی پرشدت (HIIT) بر محتوای پروتئین‌های اتوفاژی (BECLIN1 و AMBRA1) در عضله اسکلتی موش‌های صحرایی سالمند می‌باشد. مواد و روش‌ها: پژوهش حاضر از نوع تجربی-بنیادی می‌باشد که 12 سر موش صحرایی نر 20 ماهه از نژاد اسپراگ‌داولی با میانگین وزنی 30±400 گرم به‌صورت تصادفی به 2 گروه 1) کنترل (6 سر) و 2) HIIT (6 سر) تقسیم شدند. برنامه تمرین HIIT شامل 8 هفته و هفته‌ای 3 جلسه با شدت 85-90 درصد VO2max بود. بعد از 48 ساعت پس از آخرین جلسه تمرین بافت عضله EDL بدن موش‌های صحرایی برداشته شد. تجزیه و تحلیل داده‌ها داده‌ها از طریق آزمون t-مستقل در نرم‌افزار‌های SPSS نسخه 27 و گراف‌پد پریسم نسخه 2/2/10 انجام شد. سطح معنا‌داري کمتر از 05/0≥p بود. یافته‌ها: هشت هفته تمرین HIIT منجر به افزایش محتوای درون سلولی پروتئین BECLIN1 (0001/0P=) و کاهش محتوای درون سلولی پروتیئن AMBRA1 (0001/0P=) در عضله EDL موش‌های صحرایی سالمند شد. نتیجه‌گیری: با توجه به نتایج متناقض در محتوای پروتئین‌های BECLIN1 و AMBRA1 نشان می‌دهد که در تنظیم مسیر اتوفاژی پاسخ‌های تطبیقی HIIT متفاوت است. تفاصيل المقالة

Introduction: Exercise is an important strategy for reducing the risk of chronic disease, and recent research has focused on its role in the improvement of the inflammatory profile. The present study aimed to investigate the effect of a single bout of aerobic exercise on ergometer on inflammatory and hormonal markers in active girls. Methods: 16 physical education students with average age of 20.25 ±0.9 years, maximal oxygen uptake of 42.14±9.8 ml/kg/m and body mass index of 22.11±2.66 kg/m2 were randomly divided into experimental and control groups. The experimental group pedaled on ergometer with intensity of 75 % VO2max for 60 minutes and the control group had no activity during the test. Blood samples for measuring the levels of IL-10, TNF-α, CRP, cortisol, epinephrine were taken before, immediately and 2 hours after termination of the exercise. The data were analyzed by paired t-test, repeated measure ANOVA and Bonferroni post hoc at P 0.05). The mean values of CRP (P=0.002) and cortisol (P=0.001) were higher in the experimental group than the control group. In addition, the mean values of epinephrine in the control group were higher than the experimental group (P=0.009), while no significant difference was observed between the two experimental and control groups in the concentration of IL-10 (P> 0.05). Conclusion: Based on the findings of study, it seems that an exercise session on an ergometer does not affect hormonal and inflammatory factors in active subjects. تفاصيل المقالة

Introduction: Addressing physical activities is one of the important pillars of the health management of patients with breast cancer. The purpose of this study was to investigate the effect of Pilates training on isoprostane, fasting glucose and body composition in women with breast cancer. Methods: In this quasi-experimental study, 24 women with breast cancer who referred to health and therapy centers and private clinics of Shiraz were selected and divided into two groups: Pilates training and control. Pilates training group performed exercises for 10 weeks, 3 sessions per week and 60 minutes each session. The control group performed only their daily activities during this period. Blood sampling and physical examination were performed before and after the training period. For statistical analysis of data Kolmogorov- Smirnov, paired sample t-test and independent sample t- tests (p≤0.05) were used. Results: The results showed that ten weeks of pilates training had no significant effect on isoprostane (p=0.35), weight (p=0.09), body mass index (p=0.09) and WHR (p=0.07) in women with breast cancer. Also, Pilates training had a significant effect on the reduction of fasting glucose (p=0.03) in women with breast cancer. Conclusion: According to the findings of the present study, although 10-week Pilates training are not effective in improving the isoprostane and body composition of women with breast cancer, it can improve the fasting glucose in these patients. تفاصيل المقالة

Introduction: The present study aims to investigate the effect of one concurrent endurance and resistance exercise training session on plasma levels of vascular endothelial growth factor (VEGF) and endostatin in inactive women. Methods: In this quasi-experimental study, 12 inactive female university students were divided into control (average age=20.0 ±1.78 years, height = 161.3 ±50 cm, weight = 58.83±5.71 kg, BMI = 22.38±3.23 kg/m2) and exercise (average age =19.5±1.04 years, height = 163.1±3.79 cm, weight = 58.67±7.69 kg, BMI =22.35±2.22 kg/m2) groups. The endurance exercise was performed on a treadmill with 65% of MHR for 16 minutes. The resistance exercises of four movements including leg press, chest compression, armpit and leg stretch were performed at 50% 1RM in two sets with 10 repetitions and 1-2 minutes’ rest intervals between sets. Data were analyzed using dependent t-test and independent t-test to determine differences within the group and between-group at pthe control group (p= 0.168). Conclusion: According to the findings, it seems that one session of concurrent endurance and resistance exercise has a positive influence on VEGF and probably it can help to improve the condition of angiogenesis. تفاصيل المقالة