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المقاله
1 - Chemical constituents from the leaves and liana of <i>Salacia nitida</i> (Benth.) N.E.Br. (Celastraceae) and their antimicrobial activitiesBrice Mba’ning Joël E. T. Ateba Angelbert F. Awantu Luciana S. Amaral Gervais M. Happi Beate Neumann Georg Stammler Bruno Lenta Silvère A. Ngouela Iran Malavazi Etienne Tsamo Norbert Sewald Edson Rodrigues-FilhoTrends in Phytochemical Research , العدد 2 , السنة 3 , بهار 2019One benzophenone, 4′-hydroxy-2,4,6-trimethoxybenzophenone (1) was isolated from the liana and leaves of Salacia nitida (Benth.) N.E.Br., together with n-hexacosane (2), 29-hydroxyfriedelane (3), 3β-friedelinol (4), n-hexacosan-1-ol (5), n-octacosan-1-ol (6), أکثرOne benzophenone, 4′-hydroxy-2,4,6-trimethoxybenzophenone (1) was isolated from the liana and leaves of Salacia nitida (Benth.) N.E.Br., together with n-hexacosane (2), 29-hydroxyfriedelane (3), 3β-friedelinol (4), n-hexacosan-1-ol (5), n-octacosan-1-ol (6), mangiferin (7), β-sitosterol-3-O-β-D-glucopyranoside (8), friedelin (9), 30-hydroxyfriedelin (10), salaspermic acid (11), 22β-epi-maytenfolic acid (12), orthosphenic acid (13), maltose (14), D-mannitol (15), cangoronine (16), 7-hydroxyfriedelane-1,3-dione (17), tingenone (18), pristimerin (19), α-amyrin acetate (20), β-sitosterol (21) and stigmasterol (22), 21-hydroxyfriedelan-3-one (23), abruslactone A (24), and 2α-hydroxypopulnonic acid (25). The structures of the isolated compounds were established by means of spectroscopic analysis. In addition, the structure of (1) was confirmed by its X-ray diffraction. Compounds (1), (7), (10)-(11), (13), (16)-(19) and (25) were evaluated for their antimicrobial activities. Compound (18) showed a significant activity against Staphylococcus aureus (MIC = 23.8 µM) while compounds (11) and (19) exhibited moderate inhibiting effect against Staphylococcus aureus (MIC = 53.8 µM) and Candida glabrata (MIC = 105.9 µM), respectively. تفاصيل المقالة -
المقاله
2 - Constituents of the ripe fruits of <i>Nauclea latifolia</i> Sm. (Rubiaceae) and their antileishmanial activitiesArgan Kelly Nkwenti Wonkam Cyrille Armel Ngansop Njanpa Joël E.T. Ateba Yannick S.F. Fongang Angelbert Awantu J.J.K. Bankeu Jean Rodolph Chouna Fabrice F. Boyom Norbert Sewald Bruno LentaTrends in Phytochemical Research , العدد 4 , السنة 6 , پاییز 2022The MeOH extract of the ripe fruits of Nauclea latifolia Sm. (Rubiaceae) showed potent antileishmanial activity in vitro during preliminary screening (IC50 = 2.20 µg/mL) against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes. Three of the four fractions of t أکثرThe MeOH extract of the ripe fruits of Nauclea latifolia Sm. (Rubiaceae) showed potent antileishmanial activity in vitro during preliminary screening (IC50 = 2.20 µg/mL) against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes. Three of the four fractions of this extract showed moderate to good activities (7.06 ≤ IC50 ≤ 91.21 µg/mL) on the same strain. The purification of the fractions through CC yielded fifteen compounds whose structures were established based on their MS and NMR data. All the isolated compounds were assessed for their antileishmanial activity against L. donovani and for their cytotoxicity towards Raw 264.7 macrophage cells. 2,6-Dimethoxybenzoquinone (1) and hederagenin (6) showed good antileishmanial activity with IC50 values of 9.94 and 19.3 µM, respectively. Compound 1 was not selective, while compound 6 displayed a good selectivity towards raw 264.7 macrophage cells (SI > 7.82). These results indicate that the extract from N. latifolia fruits could be considered as a source of leishmaniacidal agents. تفاصيل المقالة