Anticancer and anti-inflammatory effects of American and European Cranberries have been previously shown on different cancer cells. Owing to the limited evidence on growth conditions and anticancer potentials of the Iranian Vaccinium genus, Vaccinium arctostaphylos, it was aimed to investigate its effect on colorectal cancer cells. In this regard, Vacciniumarctostaphylos was cultured in Woody Plant Medium (WPM) following incubation at 27°C in cycles of light and darkness. Callogenesis was induced using growth mediums containing different concentrations of 2,4-Dichlorophenoxyacetic acid (2,4-D), yeast extract, and Kinetin. Total polyphenol and antioxidant activity of prepared extracts from wet and dried callus and air-dried fruit was measured through the Folin-Ciocalteu method and DPPH assay, respectively. Various concentrations (0-500 µgr/ml) of fruit and callus extracts were examined on HCT-116 colorectal cancer cells. MTT assay was employed to determine the cytotoxicity of fruit and callus extracts. Obtained data were analyzed using Graph Pad Prism V7.04. The size and weight of the obtained callus were significantly dependent on the concentrations of 2,4-D, yeast extract, and Kinetin. Dry callus has been found to have the highest amount of polyphenol and antioxidant activity. HCT-116 cell death rate (20.5%) was demonstrated to be the most for dry callus at the concentration of 400 ‫‪µg/ml. However, half-maximal inhibitory concentration (IC50) was not achieved for none of Vaccinium arctostaphylos fruit or callus, Present evidence on cancer cell death can pave the way towards further assessment of anti-inflammatory and cancer cell cytotoxicity of the Iranian Cranberry genus. تفاصيل المقالة

Genetically modified foods (GM foods) have revolutionized the agricultural industry towards more proficient farming in every geographical region of the world. The major tasks of this GM food technology could be summarized in four points including increase in food products, more convenient food processing, disease prevention and treatment and avoiding of using pesticides through the generation of pest-resistant crops. Although the GM foods technology had great advantages for human health, there are some concerns regarding biodiversity induced by modified plants, which can indirectly affect human being, as well. Further studies are warranted to define precisely the status of this technology in ecosystem in which human is living. تفاصيل المقالة

Human brain tumors are the leading cause of cancer induced death owing to the late diagnosis in higher grades and failure to be successfully controlled. Determining the main risk factors toward higher grades of the tumor can dramatically decrease the mortality rate of benign brain tumor patients. The present study was conducted to compare the dietary habits between benign and malignant brain tumor patients. Three demographic, physical activity and dietary regimen’s specific questionnaires were filled for 50 high grade glioma and 50 meningioma patients. Obtained data were analyzed using SPSS 22.0 (SPSS Inc, IL, USA). A p-value less than 0.05 was considered as significant. There was a significant association between using of fast foods and high-grade glioma tumors (p-value=0.007). In contrast, the frequency of using dairy products, sea foods, fruits, and vegetables besides physical activity was not meaningfully different between two malignant and benign patient groups. Finding of this study regarding the association of fast foods with malignant brain tumors is further support on the role of Trans and saturated fatty acids in the rate of cancer evolution. However, further investigations are required to determine whether disruption in blood brain barrier induced by frequent consumption of saturated fatty acids enriched food occurs before or after malignant cellular transformation. تفاصيل المقالة