Drug release in the body, mainly by digestive (tablets, capsules, and syrups) and non-digestive (injections, eye drops, and creams) are known as conventional technique. In most of these methods, the drug travels through the body during exposure to the acidic environment of the stomach, passing through the tight connections of cells in the intestinal wall. This attitude is based on the fact that a sufficient concentration of the drug enters the bloodstream. The process of targeted drug delivery maintains the level of an appropriate drug concentrations for a long time and reduces many of the usual therapeutic limitations such as the number of doses used. In this research, the use of natural biopolymers in the engineering and medical engineering industries and the use of electro spraying for core-shell have been investigated. Also, the side effects of simple drug release in the systemic distribution are unclear. Each targeted delivery system includes a target drug, carrier, and ligand, in which the distribution, metabolism, and cellular uptake of the drug are determined by the physicochemical characteristics and biological behavior of the carrier and ligand. Therefore, proper carrier and ligand design increases drug efficacy in patient tissues and reduces drug toxicity in other healthy tissues. Many new techniques such as electrospray using natural polymers can use for treatment of those disease with sufficient time of drug release using an appropriate drug. تفاصيل المقالة