This research is aimed at determining the role of acceptance and mindfulness therapy on physical activity increment and obesity decrement in the patients suffering from heart disease in Bandar Abbas. In terms of type, the research is applied one and in terms of research method, it is a quasi-experimental study along with a pretest-posttest with a control group. The statistical population of the research involves all the patients suffering from heart disease being overweight who had visited Bandar Abbas’ hospitals during 2016-2017 and according to angiographic reports, the eclipse was more than 50% and BMI ≥30. An available sampling method was used in the study. The population size was 20 that 10 were assigned to the experimental group and 10 to control group. The data were collected through making use of physical activity level, body mass index (BMI) questionnaire. The obtained data were analyzed using covariance analysis and SPSS software. The results showed that acceptance therapy had been effective in physical activity increment and body mass decrement of the patients suffering from heart disease. Based on the obtained results, it can be concluded that mindfulness-based therapy can be considered as a non-invasive treatment. This clinical trial will result in more effective mindfulness-based interventions as a complementary treatment in primary care for people with overweight and obesity تفاصيل المقالة