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المقاله
1 - Segregation of the InDel Mutation in IRF2BP2 Discriminating Fleece Type in North African and Iranian Sheep BreedsF.Z. Belharfi S. Kdidi N. Tabet-Aoul A. Ameur Ameur A. Djaout M. Hammadi J. Sarry F. Woloszyn S. Fabre R. Talebi T. Khorchani M.H. Yahyaoui S.S.B. GaouarIranian Journal of Applied Animal Science , العدد 2 , السنة 14 , بهار 2024In sheep, the woolly or hairy fleece type shows variation within and between breeds and populations. Re-cently, the woolly allele was shown to result from the insertion of an antisens retrogene into the 3’UTR of the ovine IRF2BP2 gene. The purpose of this study was to e أکثرIn sheep, the woolly or hairy fleece type shows variation within and between breeds and populations. Re-cently, the woolly allele was shown to result from the insertion of an antisens retrogene into the 3’UTR of the ovine IRF2BP2 gene. The purpose of this study was to examine this InDel polymorphism within the IRF2BP2 gene using a specific PCR genotyping in 17 North African (Algeria and Tunisia) and Iranian sheep breeds showing various fleece types. The genotyping of the overall animals (n=908) showed the seg-regation of the two alleles insertion (I) and deletion (D), and the three genotypes (II, ID and DD) with vari-ous frequencies. Ouled Djellal, Rembi and Tâadmit known as woolly breeds had 100%, 94% and 94% of II homozygous animals, respectively. In contrast, Ifilène and Sidaou known as hairy breeds had 100% and 99% of DD homozygous animals. Other breeds showed the segregation of the I allele with a frequency from 3% to 91%. An association analysis, carried out only for the Algerian sheep breeds, revealed that this poly-morphism was significantly associated with the fleece type trait (P<0.05). Thus, the current work meets previous results to further confirm the genetic effect of the insertion occurring into the 3′ UTR of the IRF2BP2 gene on the fleece type trait of sheep breeds. تفاصيل المقالة
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