Background & Aim: This study was designed to evaluate the therapeutic effect of Allium cepa on the atherogenic, serum biochemical, and hematologic indices in Wistar rats administered KBrO3.Experimental: Forty male rats assigned into 8 groups (n=5) in which groups A, B, C, D, and E received distilled water (2 mL), KBrO3 (50 mg/kg), quercetin 70 mg/kg, aqueous extract of Allium cepa (AEAC) at 150 mg/kg and 300 mg/kg, respectively. Groups F, G, and H received KBrO3 with AEAC at 150 mg/kg, 300 mg/kg, and quercetin, respectively, on alternate days for 3 months.Results: The phytochemical analysis of the AEAC revealed the presence and absence of some phytochemical constituents. The Acute toxicity result indicated that AEAC has an LD50 above 5000mg/kg. KBrO3 caused a significant (P<0.05) decrease in the haematological parameters relative to the control but administration of KBrO3 with AEAC or quercetin improved the parameters. KBrO3 caused a significant (P<0.05) increase in the levels of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), but significantly (P<0.05) lower level of HDL-C. Treatment with KBrO3 and AEAC or quercetin significantly (P<0.05) abrogated these KBrO3-induced alterations. Similar ameliorative effects of AEAC were found in KBrO3-induced alterations in atherogenic indices, such as Castelli's Risk Index I (CRI-1), Castelli's Risk Index II (CRI-II), Atherogenic Coefficient (AC), and Atherogenic Index of Plasma (AIP) indices relative to the control.Recommended applications/industries: According to the present results, AEAC showed amelioration against KBrO3-induced derangement in the haematological, lipid, and atherogenic indices and it might be helpful in the management of cardiovascular problems. تفاصيل المقالة

Background & Aim: This study was aimed at investigating the prophylactic effects of hydroethanolic extract of Ixora coccinea leaf (HEICL) on Cisplatin (cis diamminedichloroplatinum-II, CDDP)-induced alteration in atherogenic, haematological, and biochemical profiles in male Wistar ratsExperimental: Thirty male rats were assigned into 6 groups (n=5) in which groups A, B, C, and D received normal saline (0.2 mL), CDDP (10 mg/kg), HEICL at 200 mg/kg, and HEICL at 400mg/kg. Groups E and F received CDDP 10 mg/kg with HEICL at 200 mg/kg, and 400 mg/kg, respectively. Results: The phytochemical analysis of the AEAC revealed the presence of some phytochemical constituents such as alkaloids, flavonoids, saponins, tannins, reducing sugar, phenol, resin, and volatile oil. However, glycosides, steroids, and anthraquinone were absent. The Acute toxicity result indicated that HEICL has an LD50 above 5000mg/kg. CDDP caused a significant (P<0.05) decrease in the haematological parameters relative to the control but administration of CDDP with HEICL improved the parameters. CDDP caused a significant (P<0.05) increase in the levels of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL), but a significantly (P<0.05) lower level of HDL. Treatment with CDDP and HEICL significantly (P<0.05) abrogated these CDDP-induced alterations. Similar ameliorative effects of HEICL were found in CDDP-induced alterations in atherogenic indices, such as Castelli's Risk Index I (CRI-1), Castelli's Risk Index II (CRI-II), Atherogenic Coefficient (AC), and Atherogenic Index of Plasma (AIP) indices relative to the control.Recommended applications/industries: The above study suggests that HEICLmay be useful in treating heart conditions because it protects against CDDP-induced alterations in the haematological, lipid, and atherogenic parameters. تفاصيل المقالة