A mechanism of surface fictionalization, often referred to as click reaction, is the most widely used and accepted synthetic pathways in chemical processes today. This reaction has been used in a variety of synthesis and molecular modification applications, including biosciences, polymer sciences, material sciences, drug delivery, and the list is endless. The azide-alkyne 'click' reaction catalyzed by a metal is the most essential component to this early milestone. It is no exaggeration to claim that click chemistry has prepared the way for modern civilization in chemistry, and is thus an eye opener to current scientific practice. This paper outlines some of the key elements that have contributed to the clicks' character, as well as how they provide certain elements of perspective for scientific applications. As a result, the findings of this study imply that the chemistry of click reactions has emerged as a useful tool in biological and material chemistry. تفاصيل المقالة