تأثیر تمرین هوازی و کورکومین بر سطوح آپلین، مقاومت به انسولین و گلوکز در موش‌های صحرایی مبتلا به دیابت نوع 2
الموضوعات :
مرتضی ابراهیم زاده
1
,
کمال عزیزبیگی
2
,
خالید محمدزاده سلامت
3
,
سامان پاشایی
4
1 - گروه تربیت بدنی و علوم ورزشی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج ، ایران
2 - گروه تربیت بدنی و علوم ورزشی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج ، ایران
3 - گروه تربیت بدنی و علوم ورزشی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج ، ایران
4 - گروه تربیت بدنی و علوم ورزشی، واحد سقز، دانشگاه آزاد اسلامی، سقز، ایران
الکلمات المفتاحية: دیابت, کورکومین, تمرین هوازی, آپلین,
ملخص المقالة :
مقدمه و هدف: پژوهش‌های پیشین تأثیر مثبت تمرین هوازی و کورکومین را بر دیابت نشان داده‌اند. هدف از پژوهش حاضر بررسی اثر تمرین هوازی با و بدون مکمل کورکومین بر سطوح آپلین، مقاومت به انسولین و گلوکز در موش های مبتلا به دیابت نوع 2 بود. مواد و روش ها: 40 سر موش صحرایی نر به‌طور تصادفی به 5 گروه 8 تایی شامل شاهد سالم، شاهد دیابتی، دیابت+کورکومین، دیابت+ تمرین هوازی، دیابت +کورکومین + تمرین هوازی تقسیم شدند. پس از اعمال مداخله بر اساس نام گروه حیوانات قربانی شدند و متغیرهای مورد نظر در نمونه‌های پلاسمایی جمع آوری شده اندازه‌گیری شدند. داده‌ها با استفاده از آزمون آنالیز واریانس یک‌طرفه آنالیز شدند و ارزش P کمتر از 05/0 به‌عنوان تفاوت معنی‌دار در نظر گرفته شد. یافته ها: نتایج نشان داد تمرین هوازی با شدت متوسط باعث افزایش سطوح آپلین (05/0P<) و کاهش مقاومت انسولینی (05/0P<) و گلوکز (05/0P<) پلاسمای موش‌های دیابتی شد. استفاده از کورکومین نیز باعث افزایش سطوح آپلین (05/0P<) و کاهش مقاومت انسولینی (05/0P<) و گلوکز (05/0P<) پلاسمای موش‌های دیابتی شد. بحث و نتیجه گیری: تمرین هوازی با شدت متوسط می‌تواند راه‌حلی مناسب برای کاهش قند خون و جلوگیری از افزایش آن در پی بیماری دیابت شود. همچنین، مصرف کورکومین در محدوده مقادیر سلامت به همراه تمرین هوازی می‌تواند بر حصول نتایج بهتر تأثیر بگذارد.
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