ارزیابی شاخص قلبی به عنوان معیاری جهت خاتمه احیاء با مایع‌درمانی در سگ‌های دچار شوک هیپوولمیک
الموضوعات :
رضا آذرگون
1
,
رضا آویزه
2
,
علیرضا غدیری
3
,
محمد راضی جلالی
4
,
مهدی پورمهدی بروجنی
5
,
هادی ایمانی راستابی
6
1 - استادیار گروه بیماریهای درونی و کلینیکال پاتولوژی، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران.
2 - استاد گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران.
3 - استاد گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران.
4 - استاد گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران.
5 - دانشیار گروه بهداشت مواد غذایی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران.
6 - استادیار گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران.
تاريخ الإرسال : 24 السبت , ربيع الثاني, 1441
تاريخ التأكيد : 10 الثلاثاء , ربيع الأول, 1442
تاريخ الإصدار : 05 الخميس , ربيع الأول, 1442
الکلمات المفتاحية:
سگ,
شاخص قلبی,
شوک هیپوولمیک,
ملخص المقالة :
شاخص قلبی، که با تقسیم‌نمودن برون‌ده قلب بر سطح بدن به‌دست می‌آید، به عنوان پارامتری استاندارد جهت بررسی پرفیوژن بافتی شناخته می‌شود. هدف مطالعه حاضر، ارزیابی تغییرات شاخص فوق، به عنوان معیاری جدید جهت تخمین زمان خاتمه مایع‌درمانی در سگ‌های دچار شوک هیپوولمیک بود. به این منظور 10 قلاده سگ نژاد مخلوط انتخاب و پس از تعیین سطح بدن، برون‌ده قلب بهوسیله اکوکاردیوگرافی داپلر طی هشت مرحله اندازه‌گیری شد. پس از القاء بیهوشی و ثبت علایم حیاتی، ارزیابی شاخص قلبی در مرحله کنترل انجام گردید. شوک هیپوولمیک با خون‌گیری تا رسیدن به فشار‌خون میانگینسرخرگی بین 40 تا 50 میلی‌متر جیوه در عرض 30 دقیقه ایجاد و سپس به مدت 30 دقیقه در شرایط هیپوولمی حفظ شد. سپس سگ‌ها به صورت تصادفی به دو گروه مساوی تقسیم شدند و هر گروه با محلول رینگر لاکتات (20 میلی‌لیتر بر کیلوگرم) یا هیدروکسی اتیل استارچ 6 درصد (5 میلی‌لیتر بر کیلوگرم) در چهار بازه زمانی 15 دقیقه‌ای احیاء شدند. تا یک ساعت پس از آخرین مرحله احیاء، سگ‌ها مورد پایش قرار گرفته و در پایان هر مرحله ارزیابی شاخص قلبی صورت پذیرفت. مشخص شد که شوک هیپوولمیک موجب کاهش معنی‌دار شاخص قلبی (1/0±3/2) نسبت به مرحله کنترل (6/0±8/4) گردیده است (05/0>p < /em>). همچنین متعاقب احیاء، شاخص قلبی افزایش یافت و در هر دو گروه به مقادیر پیش از شوک بازگشت. بر اساس نتایج مطالعه حاضر، می‌توان اعلام کرد که ارزیابی اکوکاردیوگرافیک شاخص قلبی، معیاری ایده‌آل جهت تخمین زمان خاتمه احیاء در سگ‌های دچار شوک هیپوولمیک می‌باشد.
المصادر:
Antonelli, M., Levy, M., Andrews, P.J., Chastre, J., Hudson, L.D., Manthous, C., et al. (2007). Hemodynamic monitoring in shock and implications for management. Intensive Care Medicine, 33(4): 575-590.
Assadnassab, G.H., Mousavi, G.H. and Neshat Gharamaleky, M. (2008). Ultrasonographic measurement of canine aorta and aortic inlet before and after administration of Propofol. Veterinary Clinical Pathology, 2(3): 241-247. [In Persian]
Aya, H.D., Rhodes, A., Chis Ster, I., Fletcher, N., Grounds, R.M. and Cecconi, M. (2017). Hemodynamic effect of different doses of fluids for a fluid challenge: A quasi-randomized controlled study. Critical Care Medicine, 45(2): e161–e168.
Boothe, D.M. (2017). Drug selection and dosing regimens. In: Monitoring and Intervention for the Critically Ill Small Animal. Kirby, R. and Linklater, A. editors. 1st ed., Iowa: Wiley-Blackwell, pp: 177-206.
Braz, J., Nascimento, P., Filho, O., Braz, L., Vane, L.A., Galva˜oVianna, P.T., et al. (2004). The Early Systemic and Gastrointestinal Oxygenation Effects of Hemorrhagic Shock Resuscitation with Hypertonic Saline and Hypertonic Saline 6% Dextran-70: A Comparative Study in Dogs. Anesthesia and Analgesia, 99(2): 536-546.
Davis, H. (2016). Management of Patients in Shock. In: Small animal emergency and critical care for veterinary technicians. Battaglia, A.M. and Steele, A.M. editors. 3th ed., Missouri: Elsevier, pp: 223-233.
Dinh, V.A., Ko, H.S., Rao, R., Bansal, R.C., Smith, D.D., Kim, T.E, et al. (2012). Measuring cardiac index with a focused cardiac ultrasound examination in the ED. American Journal of Emergency Medicine, 30(9): 1845-1851.
Dipti, A., Soucy, Z., Surana, A. and Chandra, S. (2012). Role of inferior vena cava diameter in assessment of volume status: a meta-analysis. Emergency Medicine, 30(8): 1414-1419.
Fakler, U., Pauli, Ch., Balling, G., Lorenz, H.P., Eicken, A., Hennig, M., et al. (2007). Cardiac index monitoring by pulse contour analysis and thermodilution after pediatric cardiac surgery. The Journal of Thoracic and Cardiovascular Surgery, 133(1): 224-228.
Fine, D.M., Durham, H.E., Rossi, N.F., Spier, A.W., Selting, K. and Rubin, L.J. (2010). Echocardiographic assessment of hemodynamic changes produced by two methods of inducing fluid deficit in dogs. Journal of Veterinary Internal Medicine, 24(2): 348-353.
Fülöp, A., Turóczi, Z., Garbaisz, D., Harsányi, L. and Szijártó, A. (2013). Experimental Models of Hemorrhagic Shock: A Review. European Surgical Research, 50(2): 57-70.
Gutierrez, G., Reines, H.D. and Wulf-Gutierrez, M.E. (2004). Clinical review: Hemorrhagic shock. Critical Care, 8(5): 373-381.
Guyton, A.C. (1995). Determination of cardiac output by equating venous return curves with cardiac response curves. Physiological Reviews, 35(1): 123–129.
Hasanpour, A., Amougli Tabrizi, B., Rezaie Saber, A.P. and Imandar, M. (2009). Evaluating the effect of administrating hypertonic and isotonic saline solutions on clinical improvement, serum electrolyte concentrations and renal function of calves affected by diarrhea. Veterinary Clinical Pathology, 3(3): 579-590. [In Persian]
Haskins, S.C., Pascoe, P.J., Ilkiw, J.E., Fudge, M., Hopper, K. and Aldrich, J. (2005). The effect of moderate hypovolemia on cardiopulmonary function in dogs. Journal of Veterinary Emergency and Critical Care, 15(2): 100-109.
Keefe, J. (2012). Shock and Initial Stabilization. In: Veterinary Technician's Manual for Small Animal Emergency and Critical Care. Norkus, C. editors. 1st ed., Iowa: Wiley-Blackwell, pp: 25-43.
Ko, J.J., Alam, R. and Kim, N.S. (2012). Hemodynamic effects of fluid resuscitation with 6% hydroxyethyl starch and whole blood in experimental hypovolemic shock in Beagle dogs. Turkish Journal of Veterinary and Animal Sciences, 36(4): 416-423.
Long, E., Babl, F.E., Oakley, E., Sheridan, B. and Duke, T. (2018). Cardiac Index Changes with Fluid Bolus Therapy in Children with Sepsis-An Observational Study. Pediatric Critical Care Medicine, 19(6): 513-518.
Lopes, P.C., Sousa, M.G., Camacho, A.A., Carareto, R., Nishimori, C., Santos, P., et al. (2010). Comparison between two methods for cardiac output measurement in propofol-anesthetized dogs: thermodilution and Doppler. Veterinary Anaesthesia and Analgesia, 37(5): 401-408.
Mazzaferro, E. and Powell, LL. (2013). Fluid therapy for the emergent small animal patient. Veterinary Clinics of North America: Small Animal Practice, 43(4): 721-734.
McLean, A.S. (2016). Echocardiography in shock management. Critical Care, 20: 275.
Mellema, M.S. and McIntyre, R.L. (2015). Cardiac output monitoring. In: Small animal critical care medicine. Silverstein, D.C. and Hopper, K. editors. 2nd ed., Missouri: Elsevier, pp: 962-966.
Mousavi, G.H. (2015). Preventive effects of Naringenin (Citrus flavonone) on intestinal ischemia–reperfusion injury in the rat. Veterinary Clinical Pathology, 8(4): 675-689. [In Persian]
Nascimento, P.Jr., De Paiva Filho, O., de Carvalho, L.R. and Braz, J.R. (2006). Early Hemodynamic and Renal Effects of Hemorrhagic Shock Resuscitation with Lactated Ringer’s Solution, Hydroxyethyl Starch, and Hypertonic Saline with or without 6% Dextran-70. The Journal of Surgical Research, 136(1): 98-105.
Tao, J.P., Huang, Q.Q., Huang, H.Q., Yang, J.J., Shi, M., Zhou, Y., et al. (2015). Effects of goal-directed fluid therapy with different lactated Ringer's: hydroxyethyl starch ratios in hemorrhagic shock dogs. Genetics and Molecular Research, 14(2): 6649-6663.
Weekes, A.J. and Quirke D.P. (2011). Emergency echocardiography. Emergency Medicine Clinics of North America, 29(4): 759-787.
_||_
Antonelli, M., Levy, M., Andrews, P.J., Chastre, J., Hudson, L.D., Manthous, C., et al. (2007). Hemodynamic monitoring in shock and implications for management. Intensive Care Medicine, 33(4): 575-590.
Assadnassab, G.H., Mousavi, G.H. and Neshat Gharamaleky, M. (2008). Ultrasonographic measurement of canine aorta and aortic inlet before and after administration of Propofol. Veterinary Clinical Pathology, 2(3): 241-247. [In Persian]
Aya, H.D., Rhodes, A., Chis Ster, I., Fletcher, N., Grounds, R.M. and Cecconi, M. (2017). Hemodynamic effect of different doses of fluids for a fluid challenge: A quasi-randomized controlled study. Critical Care Medicine, 45(2): e161–e168.
Boothe, D.M. (2017). Drug selection and dosing regimens. In: Monitoring and Intervention for the Critically Ill Small Animal. Kirby, R. and Linklater, A. editors. 1st ed., Iowa: Wiley-Blackwell, pp: 177-206.
Braz, J., Nascimento, P., Filho, O., Braz, L., Vane, L.A., Galva˜oVianna, P.T., et al. (2004). The Early Systemic and Gastrointestinal Oxygenation Effects of Hemorrhagic Shock Resuscitation with Hypertonic Saline and Hypertonic Saline 6% Dextran-70: A Comparative Study in Dogs. Anesthesia and Analgesia, 99(2): 536-546.
Davis, H. (2016). Management of Patients in Shock. In: Small animal emergency and critical care for veterinary technicians. Battaglia, A.M. and Steele, A.M. editors. 3th ed., Missouri: Elsevier, pp: 223-233.
Dinh, V.A., Ko, H.S., Rao, R., Bansal, R.C., Smith, D.D., Kim, T.E, et al. (2012). Measuring cardiac index with a focused cardiac ultrasound examination in the ED. American Journal of Emergency Medicine, 30(9): 1845-1851.
Dipti, A., Soucy, Z., Surana, A. and Chandra, S. (2012). Role of inferior vena cava diameter in assessment of volume status: a meta-analysis. Emergency Medicine, 30(8): 1414-1419.
Fakler, U., Pauli, Ch., Balling, G., Lorenz, H.P., Eicken, A., Hennig, M., et al. (2007). Cardiac index monitoring by pulse contour analysis and thermodilution after pediatric cardiac surgery. The Journal of Thoracic and Cardiovascular Surgery, 133(1): 224-228.
Fine, D.M., Durham, H.E., Rossi, N.F., Spier, A.W., Selting, K. and Rubin, L.J. (2010). Echocardiographic assessment of hemodynamic changes produced by two methods of inducing fluid deficit in dogs. Journal of Veterinary Internal Medicine, 24(2): 348-353.
Fülöp, A., Turóczi, Z., Garbaisz, D., Harsányi, L. and Szijártó, A. (2013). Experimental Models of Hemorrhagic Shock: A Review. European Surgical Research, 50(2): 57-70.
Gutierrez, G., Reines, H.D. and Wulf-Gutierrez, M.E. (2004). Clinical review: Hemorrhagic shock. Critical Care, 8(5): 373-381.
Guyton, A.C. (1995). Determination of cardiac output by equating venous return curves with cardiac response curves. Physiological Reviews, 35(1): 123–129.
Hasanpour, A., Amougli Tabrizi, B., Rezaie Saber, A.P. and Imandar, M. (2009). Evaluating the effect of administrating hypertonic and isotonic saline solutions on clinical improvement, serum electrolyte concentrations and renal function of calves affected by diarrhea. Veterinary Clinical Pathology, 3(3): 579-590. [In Persian]
Haskins, S.C., Pascoe, P.J., Ilkiw, J.E., Fudge, M., Hopper, K. and Aldrich, J. (2005). The effect of moderate hypovolemia on cardiopulmonary function in dogs. Journal of Veterinary Emergency and Critical Care, 15(2): 100-109.
Keefe, J. (2012). Shock and Initial Stabilization. In: Veterinary Technician's Manual for Small Animal Emergency and Critical Care. Norkus, C. editors. 1st ed., Iowa: Wiley-Blackwell, pp: 25-43.
Ko, J.J., Alam, R. and Kim, N.S. (2012). Hemodynamic effects of fluid resuscitation with 6% hydroxyethyl starch and whole blood in experimental hypovolemic shock in Beagle dogs. Turkish Journal of Veterinary and Animal Sciences, 36(4): 416-423.
Long, E., Babl, F.E., Oakley, E., Sheridan, B. and Duke, T. (2018). Cardiac Index Changes with Fluid Bolus Therapy in Children with Sepsis-An Observational Study. Pediatric Critical Care Medicine, 19(6): 513-518.
Lopes, P.C., Sousa, M.G., Camacho, A.A., Carareto, R., Nishimori, C., Santos, P., et al. (2010). Comparison between two methods for cardiac output measurement in propofol-anesthetized dogs: thermodilution and Doppler. Veterinary Anaesthesia and Analgesia, 37(5): 401-408.
Mazzaferro, E. and Powell, LL. (2013). Fluid therapy for the emergent small animal patient. Veterinary Clinics of North America: Small Animal Practice, 43(4): 721-734.
McLean, A.S. (2016). Echocardiography in shock management. Critical Care, 20: 275.
Mellema, M.S. and McIntyre, R.L. (2015). Cardiac output monitoring. In: Small animal critical care medicine. Silverstein, D.C. and Hopper, K. editors. 2nd ed., Missouri: Elsevier, pp: 962-966.
Mousavi, G.H. (2015). Preventive effects of Naringenin (Citrus flavonone) on intestinal ischemia–reperfusion injury in the rat. Veterinary Clinical Pathology, 8(4): 675-689. [In Persian]
Nascimento, P.Jr., De Paiva Filho, O., de Carvalho, L.R. and Braz, J.R. (2006). Early Hemodynamic and Renal Effects of Hemorrhagic Shock Resuscitation with Lactated Ringer’s Solution, Hydroxyethyl Starch, and Hypertonic Saline with or without 6% Dextran-70. The Journal of Surgical Research, 136(1): 98-105.
Tao, J.P., Huang, Q.Q., Huang, H.Q., Yang, J.J., Shi, M., Zhou, Y., et al. (2015). Effects of goal-directed fluid therapy with different lactated Ringer's: hydroxyethyl starch ratios in hemorrhagic shock dogs. Genetics and Molecular Research, 14(2): 6649-6663.
Weekes, A.J. and Quirke D.P. (2011). Emergency echocardiography. Emergency Medicine Clinics of North America, 29(4): 759-787.
