آسیب‌شناسی بافتی بیماری طاعون نشخوارکنندگان کوچک در بزها و گوسفندان منطقه سیستان
الموضوعات :
یاسمن درخشان
1
,
سیده آیدا داوری
2
,
علی سارانی
3
1 - دانش‌آموخته دکترای حرفه‌ای دامپزشکی، دانشکده دامپزشکی، دانشگاه زابل، زابل، ایران.
2 - استادیار گروه پاتوبیولوژی، دانشکده دامپزشکی، دانشگاه زابل، زابل، ایران.
3 - استادیار گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه زابل، زابل، ایران.
تاريخ الإرسال : 08 الجمعة , شوال, 1439
تاريخ التأكيد : 11 الثلاثاء , شعبان, 1440
تاريخ الإصدار : 25 الجمعة , ربيع الأول, 1441
الکلمات المفتاحية:
گوسفند,
سیستان,
بز,
آسیب‌شناسی بافتی,
طاعون نشخوارکنندگان کوچک,
ملخص المقالة :
طاعون نشخوارکنندگان کوچک (peste des petits ruminants; PPR) بیماری ویروسی واگیردار مهم گوسفند و بز می باشد. با توجه به اهمیت PPR در سیستان، مضرات اقتصادی ناشی از تلفات و هزینه های درمانی، مصرف بالای گوشت دام به شیوه ذبح سنتی و عدم نظارت کافی بر سلامت دام‌ها، مطالعه حاضر با هدف آسیب شناسی بافتی بیماری مذکور در جمعیت گوسفند و بز منطقه سیستان صورت گرفت. از 30 رأس گوسفند و بز گله های مشکوک به بیماری، نمونه های بافتی از دهان، ریه، روده‌ها و غدد لنفاوی جمع‌آوری و پس از تهیه مقطع مورد مطالعه میکروسکوپی قرار گرفتند. تعداد 9 نمونه دارای آسیب های بافتی بودند.داده ها با نرم‌افزار SPSS و آزمون کاپا مورد تحلیل آماری قرار گرفت. میزان آلودگی در گوسفند و بز به ترتیب 25/33 و 88/38 درصد بود که ارتباط آماری معنی داری بین گونه دامی و آسیب های بافتی همچون تجمع سلول‌های آماسی چندهسته‌ای و تشکیل سلول‌های سینسیتیا مشاهده شد (05/0>p ). همچنینمیزان عفونت در سنین زیر دو سال و بالای دو سال به ترتیب 18/35و 8/22 درصدبود و ارتباط آماری معنی داری از نظر سن دام و شدت تجمع سلول های آماسی تک هسته‌ای هم وجود داشت (05/0>p ). میزان آلودگی در جنس نر و ماده هم به ترتیب 98/49و 5/12 درصدبود و ارتباط آماریمعنی داری از نظر جنسیت دام و میزان بروز آسیب هایی چون تجمع سلول های آماسی چندهسته‌ای، تشکیل سلول های سینسیتیا وگنجیدگی‌های درون سیتوپلاسمی نیز مشاهده شد (05/0>p ). این مطالعه نشان داد که PPRدر منطقه سیستان در بزهای زیر دو سال با احتمال وقوع بیشتر و ضایعات پاتولوژیک شدیدتری همراه است.
المصادر:
Abdollahpour, G., Raoofi, A., Najafi, J., Sasani, F. and Sakhaie, E. (2006). Clinical and paraclinical findings of a recent outbreaks of Peste des petits ruminants in Iran. Zoonoses and Public Health, 53(s1): 14-16.
Abubakar, M., Ali, Q. and Khan, H.A. (2008). Prevalence and mortality rate of peste des petitis ruminant (PPR): possible association with abortion in goat. Tropical Animal Health and Production, 40(5): 317-321.
Al-Dubaib, M.A. (2009). Peste des petitis ruminants morbillivirus infection in lambs and young goats at Qassim region, Saudi Arabia. Tropical Animal Health and Production, 41(2): 217-220.
Al-Naeem, A., Abu, E.E. and Al-Afaleq, A.I. (2000). Epizootiological aspects of peste des petits ruminants and rinderpest in sheep and goats in Saudi Arabia. Revue Scientifique Et Technique, 19(3): 855-858.
Aruni, A.W., Lalitha, P.S., Mohan, A.C., Chitravelu, P. and Anbumani, S.P. (1998). Histopathological study of a natural outbreak of peste des petits ruminants in goats of Tamilnadu. Small Ruminant Research, 28(3): 233-240.
Atta-ur-Rahman, M.A., Rahman, S.U., Akhtar, M. and Ullah, S. (2004). Peste des petits ruminants antigen in mesenteric lymph nodes of goats slaughtered at DI Khan. Pakistan Veterinary Journal, 24(3): 159-160.
Bazarghani, T.T., Charkhkar, S., Doroudi, J. and Bani Hassan, E. (2006). A Review on Peste des Petits Ruminants (PPR) with Special Reference to PPR in Iran. Journal of Veterinary Medicine Series B, 53(s1): 17-18.
Cam, Y., Gencay, A., Beyaz, L., Atalay, O., Atasever, A., Özkul, A., et al. (2005). Peste des petits ruminants in a sheep and goat flock in Kayseri province, Turkey. Veterinary Record, 157: 523-524.
Chauhan, H.C., Chandel, B.S., Kher, H.N., Dadawala, A.I. and Agrawal, S.M. (2009). Pesti des petits ruminants virus infection in animals. Veterinary World, 2(4): 443-447.
Davari, S.A., Sayyari, M. and Mohammadi, A. (2013). Genetic analysis of the viral agents causing muzzle crust in small ruminants of Shiraz, Iran. Bulgarian Journal of Veterinary Medicine, 16(3): 159-169.
Diallo, A., Minet, C., Le Goff, C., Berhe, G., Albina, E., Libeau, G., et al. (2007). The threat of peste des petits ruminants: progress in vaccine development for disease control. Vaccine, 25(30): 5591-5597.
Esmaelizad, M., Jelokhani, S. and Kargar-Moakhar, R. (2011). Phylogenetic analysis of peste des petits ruminants virus (PPRV) isolated in Iran based on partial sequence data from the fusion (F) protein gene. Turkish Journal of Biology, 35(1): 45-50.
Fallahi, R. (2017). Isolation and molecular diagnosis of Peste des petits ruminants (PPR) virus from contaminated areas in Iran. Iranian Journal of Veterinary Science and Technology, 9(1): 17-21.
Foroughi, A., Chaharaein, B., Ownagh, A. and Mardani, K. (2013). Comparison of c-ELISA and RT-PCR methods in detection of Peste Des Petits Ruminants in early stage from clinical specimens in goats and sheep in Kermanshah Province. Experimental Animal Biology, 2(1): 51-56. [In Persian]
Kataria, A.K., Kataria, N. and Gahlot, A.K. (2007). Large scale outbreaks of peste des petits ruminants in sheep and goats in Thar Desert of India. Slovenian Veterinary Research, 44(4): 123-132.
Khan, H.A., Siddique, M., Arshad, M.J., Khan, Q.M. and Rehman, S.U. (2007). Sero-prevalence of peste des petits ruminants (PPR) virus in sheep and goats in Punjab province of Pakistan. Pakistan Veterinary Journal, 27(3): 109-112.
Khan, M.A., Hussain, S.N., Bahadar, S., Ali A. and Shah I.A. (2008). An outbreak of peste des petits ruminants (PPR) in goats in district Chitral, N.W.F.P., Pakistan. ARPN Journal of Agricultural and Biological Science, 3(2): 19-22.
Khan, M.R., Haider, M.G., Alam, K.J., Hossain, M.G., Chowdhury, S.M.Z.H. and Hossain, M.M. (2012). Pathological investigation of Peste des Petits Ruminants (PPR) in goats. Bangladesh Journal of Veterinary Medicine, 3(2): 134-138.
Mahajan, V., Filia, G., Bal, M.S., Kaur, G., Sharma, S., Dantotia, A., et al. (2017). Outbreaks of Peste Des Petits Ruminants (PPR) in goats in Punjab, India. International Journal of Current Microbiology and Applied Sciences, 6(8): 3705-3710.
Marashi, M., Masoudi, S., Moghadam, M.K., Modirrousta, H., Marashi, M., Parvizifar, M., et al. (2017). Peste des Petits Ruminants virus in vulnerable wild small ruminants, Iran, 2014-2016. Emerging Infectious Diseases, 23(4): 704-706.
Mokhtari, A., Azizi, Z. and Rabiaee Fradonbeh, S. (2017). Epidemiological study and spatial modeling of peste des petits ruminants (PPR) in central area of Iran. Revista MVZ Córdoba, 22(2): 5899-5909.
Özkul, A., Akca, Y., Alkan, F., Barrett, T., Karaoglu, T., Dagalp, S.B. and Burgu, I. (2002). Prevalence, distribution, and host range of Peste des petits ruminants virus, Turkey. Emerging Infectious Diseases, 8(7): 709-712.
Patel, J.M., Patel, D.R., Mavadiya, S.V., Solanki, J.B., Vihol, P.D., Sharma, K.K., et al. (2015). Clinicopathological investigation of an outbreak of peste des petits ruminants in small ruminants in South Gujarat, India. Indian Journal of Veterinary Pathology, 39(1): 20-23.
Rajak, K.K., Sreenivasa, B.P., Hosamani, M., Singh, R.P., Singh, S.K., Singh, R.K., et al. (2005). Experimental studies on immunosuppressive effects of peste des petits ruminants (PPR) virus in goats. Comparative Immunology, Microbiology and Infectious Diseases, 28(4): 287-296.
Rezazadeh, F., Madadgar, O. and Poureini, F. (2016). Study of Peste Des Petits Ruminants (PPR) in some border Areas of Iran by Nested- PCR. Iranian Journal of Ruminants Health Research, 1(1): 61-72.
Singh, R.P., Saravanan, P., Sreenivasa, B.P., Singh, R.K. and Bandyopadhyay, S.K. (2004). Prevalence and distribution of peste des petits ruminant’s virus infection in small ruminant’s in India. Revue Scientifique Et Technique, 23(3): 807-819.
Toplu, N. (2004). Characteristic and non-characteristic pathological findings in peste des petits ruminant’s (PPR) of sheep in the Ege district of Turkey. Journal of Comparative Pathology, 131(2): 135-141.
Truong, T., Boshra, H., Embury-Hyatt, C., Nfon, C., Gerdts, V., Tikoo, S., et al. (2014). Peste des petits ruminants virus tissue tropism and pathogenesis in sheep and goats following experimental infection. PLOS ONE, 9(1): e87145.
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Abdollahpour, G., Raoofi, A., Najafi, J., Sasani, F. and Sakhaie, E. (2006). Clinical and paraclinical findings of a recent outbreaks of Peste des petits ruminants in Iran. Zoonoses and Public Health, 53(s1): 14-16.
Abubakar, M., Ali, Q. and Khan, H.A. (2008). Prevalence and mortality rate of peste des petitis ruminant (PPR): possible association with abortion in goat. Tropical Animal Health and Production, 40(5): 317-321.
Al-Dubaib, M.A. (2009). Peste des petitis ruminants morbillivirus infection in lambs and young goats at Qassim region, Saudi Arabia. Tropical Animal Health and Production, 41(2): 217-220.
Al-Naeem, A., Abu, E.E. and Al-Afaleq, A.I. (2000). Epizootiological aspects of peste des petits ruminants and rinderpest in sheep and goats in Saudi Arabia. Revue Scientifique Et Technique, 19(3): 855-858.
Aruni, A.W., Lalitha, P.S., Mohan, A.C., Chitravelu, P. and Anbumani, S.P. (1998). Histopathological study of a natural outbreak of peste des petits ruminants in goats of Tamilnadu. Small Ruminant Research, 28(3): 233-240.
Atta-ur-Rahman, M.A., Rahman, S.U., Akhtar, M. and Ullah, S. (2004). Peste des petits ruminants antigen in mesenteric lymph nodes of goats slaughtered at DI Khan. Pakistan Veterinary Journal, 24(3): 159-160.
Bazarghani, T.T., Charkhkar, S., Doroudi, J. and Bani Hassan, E. (2006). A Review on Peste des Petits Ruminants (PPR) with Special Reference to PPR in Iran. Journal of Veterinary Medicine Series B, 53(s1): 17-18.
Cam, Y., Gencay, A., Beyaz, L., Atalay, O., Atasever, A., Özkul, A., et al. (2005). Peste des petits ruminants in a sheep and goat flock in Kayseri province, Turkey. Veterinary Record, 157: 523-524.
Chauhan, H.C., Chandel, B.S., Kher, H.N., Dadawala, A.I. and Agrawal, S.M. (2009). Pesti des petits ruminants virus infection in animals. Veterinary World, 2(4): 443-447.
Davari, S.A., Sayyari, M. and Mohammadi, A. (2013). Genetic analysis of the viral agents causing muzzle crust in small ruminants of Shiraz, Iran. Bulgarian Journal of Veterinary Medicine, 16(3): 159-169.
Diallo, A., Minet, C., Le Goff, C., Berhe, G., Albina, E., Libeau, G., et al. (2007). The threat of peste des petits ruminants: progress in vaccine development for disease control. Vaccine, 25(30): 5591-5597.
Esmaelizad, M., Jelokhani, S. and Kargar-Moakhar, R. (2011). Phylogenetic analysis of peste des petits ruminants virus (PPRV) isolated in Iran based on partial sequence data from the fusion (F) protein gene. Turkish Journal of Biology, 35(1): 45-50.
Fallahi, R. (2017). Isolation and molecular diagnosis of Peste des petits ruminants (PPR) virus from contaminated areas in Iran. Iranian Journal of Veterinary Science and Technology, 9(1): 17-21.
Foroughi, A., Chaharaein, B., Ownagh, A. and Mardani, K. (2013). Comparison of c-ELISA and RT-PCR methods in detection of Peste Des Petits Ruminants in early stage from clinical specimens in goats and sheep in Kermanshah Province. Experimental Animal Biology, 2(1): 51-56. [In Persian]
Kataria, A.K., Kataria, N. and Gahlot, A.K. (2007). Large scale outbreaks of peste des petits ruminants in sheep and goats in Thar Desert of India. Slovenian Veterinary Research, 44(4): 123-132.
Khan, H.A., Siddique, M., Arshad, M.J., Khan, Q.M. and Rehman, S.U. (2007). Sero-prevalence of peste des petits ruminants (PPR) virus in sheep and goats in Punjab province of Pakistan. Pakistan Veterinary Journal, 27(3): 109-112.
Khan, M.A., Hussain, S.N., Bahadar, S., Ali A. and Shah I.A. (2008). An outbreak of peste des petits ruminants (PPR) in goats in district Chitral, N.W.F.P., Pakistan. ARPN Journal of Agricultural and Biological Science, 3(2): 19-22.
Khan, M.R., Haider, M.G., Alam, K.J., Hossain, M.G., Chowdhury, S.M.Z.H. and Hossain, M.M. (2012). Pathological investigation of Peste des Petits Ruminants (PPR) in goats. Bangladesh Journal of Veterinary Medicine, 3(2): 134-138.
Mahajan, V., Filia, G., Bal, M.S., Kaur, G., Sharma, S., Dantotia, A., et al. (2017). Outbreaks of Peste Des Petits Ruminants (PPR) in goats in Punjab, India. International Journal of Current Microbiology and Applied Sciences, 6(8): 3705-3710.
Marashi, M., Masoudi, S., Moghadam, M.K., Modirrousta, H., Marashi, M., Parvizifar, M., et al. (2017). Peste des Petits Ruminants virus in vulnerable wild small ruminants, Iran, 2014-2016. Emerging Infectious Diseases, 23(4): 704-706.
Mokhtari, A., Azizi, Z. and Rabiaee Fradonbeh, S. (2017). Epidemiological study and spatial modeling of peste des petits ruminants (PPR) in central area of Iran. Revista MVZ Córdoba, 22(2): 5899-5909.
Özkul, A., Akca, Y., Alkan, F., Barrett, T., Karaoglu, T., Dagalp, S.B. and Burgu, I. (2002). Prevalence, distribution, and host range of Peste des petits ruminants virus, Turkey. Emerging Infectious Diseases, 8(7): 709-712.
Patel, J.M., Patel, D.R., Mavadiya, S.V., Solanki, J.B., Vihol, P.D., Sharma, K.K., et al. (2015). Clinicopathological investigation of an outbreak of peste des petits ruminants in small ruminants in South Gujarat, India. Indian Journal of Veterinary Pathology, 39(1): 20-23.
Rajak, K.K., Sreenivasa, B.P., Hosamani, M., Singh, R.P., Singh, S.K., Singh, R.K., et al. (2005). Experimental studies on immunosuppressive effects of peste des petits ruminants (PPR) virus in goats. Comparative Immunology, Microbiology and Infectious Diseases, 28(4): 287-296.
Rezazadeh, F., Madadgar, O. and Poureini, F. (2016). Study of Peste Des Petits Ruminants (PPR) in some border Areas of Iran by Nested- PCR. Iranian Journal of Ruminants Health Research, 1(1): 61-72.
Singh, R.P., Saravanan, P., Sreenivasa, B.P., Singh, R.K. and Bandyopadhyay, S.K. (2004). Prevalence and distribution of peste des petits ruminant’s virus infection in small ruminant’s in India. Revue Scientifique Et Technique, 23(3): 807-819.
Toplu, N. (2004). Characteristic and non-characteristic pathological findings in peste des petits ruminant’s (PPR) of sheep in the Ege district of Turkey. Journal of Comparative Pathology, 131(2): 135-141.
Truong, T., Boshra, H., Embury-Hyatt, C., Nfon, C., Gerdts, V., Tikoo, S., et al. (2014). Peste des petits ruminants virus tissue tropism and pathogenesis in sheep and goats following experimental infection. PLOS ONE, 9(1): e87145.
