Diversity of chemical compounds and pharmacological properties of Cymbopogon citratus (DC) Stapf: Richness and variation of flavonoids with a wide range of biological effects
الموضوعات :
Ahmed Tazi
1
,
Noura Jaouad
2
,
Faouzi Errachidi
3
1 - Laboratory of Applied Organic Chemistry, Faculty of Sciences and Technologies, Sidi Mohamed Ben Abdellah University, Fez 30050, Morocco
2 - Laboratory of Engineering, Electrochemistry, Modeling and Environment (LIEME), Faculty of Sciences Dhar EL Mehraz, Sidi Mohamed Ben Abdellah University, Fez, 30000, Morocco
3 - Laboratory of Applied Organic Chemistry, Faculty of Sciences and Technologies, Sidi Mohamed Ben Abdellah University, Fez 30050, Morocco
الکلمات المفتاحية: Biomolecules, Cymbopogon citratus (DC) Stapf, Flavonoids, Gramineae family, In vivo, Lemongrass, Pharmacological and biological effects,
ملخص المقالة :
Cymbopogon citratus (DC) Stapf (lemongrass) is widely used in both traditional and modern medicine for the management of various ailments, owing to its chemical composition, particularly its flavonoid content. This review examines the diversity, variation, and extraction methods of these bioactive compounds, which vary depending on the plant parts used, extraction techniques, and environmental conditions. Key flavonoids identified, such as kaempferol, rutin, and quercetin, demonstrate significant pharmacological properties, including antioxidant, anti-inflammatory, antimicrobial, antidiabetic, and cardioprotective effects. They are effective against harmful pathogens, including bacteria (e.g., Vibrio, Salmonella, Staphylococcus) and fungi (e.g., Candida, Fusarium). These findings support the application of Cymbopogon citratus in both traditional and modern medicinal practices. However, further research is necessary to investigate the molecular mechanisms underlying the therapeutic effects of its flavonoids.
المصادر:
Aboagye, G., Tuah, B., Bansah, E., Tettey, C., Hunkpe, G., 2021. Comparative evaluation of antioxidant properties of lemongrass and other tea brands. Sci. Afr. 11, e00718.
Agarwal, H., Kumar, S.V., Rajeshkumar, S., 2021. Antidiabetic effect of silver nanoparticles synthesized using lemongrass (Cymbopogon citratus) through conventional heating and microwave irradiation approach. J. Microbiol. Biotechnol. Food Sci. 2021, 371-376.
Akinwunmi, O.A., Adekeye, D.K., Olagboye, S.A., 2020. Phytochemical quantification, in vitro antioxidant and antidiabetic potentials of methanol and dichloromethane extracts of Triclisia subcordata (Oliv) leaves. Trends Phytochem. Res. 4(1), 17-24.
Al Aboody, M.S., Mickymaray, S., 2020. Anti-fungal efficacy and mechanisms of flavonoids. Antibiotics 9, 45.
AlDrak, N., Abudawood, M., Hamed, S.S., Ansar, S., 2018. Effect of rutin on proinflammatory cytokines and oxidative stress in toxin-mediated hepatotoxicity. Toxin Rev. 37, 223-230.
Alekhya Sita, G.J., Gowthami, M., Srikanth, G., Krishna, M.M., Rama Sireesha, K., Sajjarao, M., Nagarjuna, K., Nagarjuna, M., Chinnaboina, G.K., Mishra, A., 2019. Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/HO-1 pathway. IUBMB Life 71, 1041-1047.
Ali, A.A.-M., Mansour, A.B., Attia, S.A., 2021. The potential protective role of apigenin against oxidative damage induced by nickel oxide nanoparticles in liver and kidney of male Wistar rat, Rattus norvegicus. Environ. Sci. Pollut. Res. 28, 27577-27592.
Alías-Villegas, C., Fuentes-Romero, F., Cuéllar, V., Navarro-Gómez, P., Soto, M.J., Vinardell, J.-M., Acosta-Jurado, S., 2022. Surface motility regulation of Sinorhizobium fredii HH103 by plant flavonoids and the NodD1, TtsI, NolR, and MucR1 symbiotic bacterial regulators. Int. J. Mol. Sci. 23, 7698.
Alkhalidy, H., Moore, W., Wang, Y., Luo, J., McMillan, R.P., Zhen, W., Zhou, K., Liu, D., 2018. The flavonoid kaempferol ameliorates streptozotocin-induced diabetes by suppressing hepatic glucose production. Molecules 23, 2338.
Alshehri, A.S., 2021. Kaempferol attenuates diabetic nephropathy in streptozotocin-induced diabetic rats by a hypoglycaemic effect and concomitant activation of the Nrf-2/Ho-1/antioxidants axis. Arch. Physiol. Biochem. 129(4), 984-997.
Altunayar-Unsalan, C., Unsalan, O., Mavromoustakos, T., 2022. Insights into molecular mechanism of action of citrus flavonoids hesperidin and naringin on lipid bilayers using spectroscopic, calorimetric, microscopic and theoretical studies. J. Mol. Liq. 347, 118411.
Anandan, S., Urooj, A., 2021. Hypoglycemic effects of apigenin from Morus indica in streptozotocin-induced diabetic rats. Int. J. Cur. Res. Rev. 13, 100.
Arora, A., Byrem, T.M., Nair, M.G., Strasburg, G.M., 2000. Modulation of liposomal membrane fluidity by flavonoids and isoflavonoids. Arch. Biochem. Biophys. 373, 102-109.
Awolola, G.V., Koorbanally, N.A., Chenia, H., Shode, F.O., Baijnath, H., 2014. Antibacterial and anti-biofilm activity of flavonoids and triterpenes isolated from the extracts of Ficus sansibarica Warb. subsp. sansibarica (Moraceae) extracts. Afr. J. Tradit. Complement. Alternat. Med. 11, 124-131.
Azimi, A., Eidi, A., Mortazavi, P., Rohani, A.H., 2021. Protective effect of apigenin on ethylene glycol-induced urolithiasis via attenuating oxidative stress and inflammatory parameters in adult male Wistar rats. Life Sci. 279, 119641.
Bailly, C., 2021. Bioactive biflavonoids from Wikstroemia indica (L.) C.A. Mey. (Thymelaeaceae): A review. Trends Phytochem. Res. 5(4), 190-198.
Barut, E.N., Engin, S., Saygın, İ., Kaya-Yasar, Y., Arici, S., Sezen, S.F., 2021. Alpha-lipoic acid: A promising adjuvant for nonsteroidal anti-inflammatory drugs therapy with improved efficacy and gastroprotection. Drug Dev. Res. 82, 844-851.
Bibens, L., Becker, J.-P., Dassonville-Klimpt, A., Sonnet, P., 2023. A review of fatty acid biosynthesis enzyme inhibitors as promising antimicrobial drugs. Pharmaceuticals 16, 425.
Biharee, A., Sharma, A., Kumar, A., Jaitak, V., 2020. Antimicrobial flavonoids as a potential substitute for overcoming antimicrobial resistance. Fitoterapia 146, 104720.
Boeira, C.P., Piovesan, N., Soquetta, M.B., Flores, D.C.B., Lucas, B.N., Rosa, C.S. da, Terra, N.N., 2018. Extraction of bioactive compounds of lemongrass, antioxidant activity and evaluation of antimicrobial activity in fresh chicken sausage. Cienc. Rural 48, e20180477.
Borges, P.H.O., Pedreiro, S., Baptista, S.J., Geraldes, C.F.G.C., Batista, M.T., Silva, M.M.C., Figueirinha, A., 2021. Inhibition of α-glucosidase by flavonoids of Cymbopogon citratus (DC) Stapf. J. Ethnopharmacol. 280, 114470.
Campos, J., Schmeda-Hirschmann, G., Leiva, E., Guzmán, L., Orrego, R., Fernández, P., González, M., Radojkovic, C., Zuñiga, F.A., Lamperti, L., 2014. Lemon grass (Cymbopogon citratus (DC) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein. Food Chem. 151, 175-181.
Caner, A., Onal, M.G., Silici, S., 2021. The effect of bee bread (Perga) with chemotherapy on MDA-MB-231 cells. Mol. Biol. Rep. 48, 2299-2306.
Carbajal, D., Casaco, A., Arruzazabala, L., Gonzalez, R., Tolon, Z., 1989. Pharmacological study of Cymbopogon citratus leaves. J. Ethnopharmacol. 25, 103-107.
Chahar, M.K., Sharma, N., Dobhal, M.P., Joshi, Y.C., 2011. Flavonoids: A versatile source of anticancer drugs. Pharmacogn. Rev. 5, 1-12.
Chen, L., Tian, G., Tang, W., Luo, W., Liu, P., Ma, Z., 2016. Protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of RIP140/NF-κB pathway and insulin signalling pathway. J. Funct. Foods 22, 93-100.
Chen, X., Qian, J., Wang, L., Li, J., Zhao, Y., Han, J., Khan, Z., Chen, X., Wang, J., Liang, G., 2018. Kaempferol attenuates hyperglycemia-induced cardiac injuries by inhibiting inflammatory responses and oxidative stress. Endocrine 60, 83-94.
Chen, Y., Zeng, H., Tian, J., Ban, X., Ma, B., Wang, Y., 2013, 2022. Antifungal mechanism of essential oil from Anethum graveolens seeds against Candida albicans. J. Med. Microbiol. 62, 1175-1183.
Comalada, M., Camuesco, D., Sierra, S., Ballester, I., Xaus, J., Gálvez, J., Zarzuelo, A., 2005. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-κB pathway. Eur. J. Immunol. 35, 584-592.
Costa, G., Ferreira, J.P., Vitorino, C., Pina, M.E., Sousa, J.J., Figueiredo, I.V., Batista, M.T., 2016a. Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agents. J. Ethnopharmacol. 178, 222-228.
Costa, G., Grangeia, H., Figueirinha, A., Figueiredo, I.V., Batista, M.T., 2016b. Influence of harvest date and material quality on polyphenolic content and antioxidant activity of Cymbopogon citratus infusion. Ind. Crops Prod. 83, 738-745.
Cotin, S., Calliste, C.-A., Mazeron, M.-C., Hantz, S., Duroux, J.-L., Rawlinson, W.D., Ploy, M.-C., Alain, S., 2012. Eight flavonoids and their potential as inhibitors of human cytomegalovirus replication. Antiviral Res. 96, 181-186.
Darabi, P., Khazali, H., Mehrabani Natanzi, M., 2020. Therapeutic potentials of the natural plant flavonoid apigenin in polycystic ovary syndrome in rat model: Via modulation of pro-inflammatory cytokines and antioxidant activity. Gynecol. Endocrinol. 36, 582-587.
Delehanty, J.B., Johnson, B.J., Hickey, T.E., Pons, T., Ligler, F.S., 2007. Binding and neutralization of lipopolysaccharides by plant proanthocyanidins. J. Nat. Prod. 70, 1718-1724.
Devi, R.C., Sim, S.M., Ismail, R., 2012. Effect of Cymbopogon citratus and citral on vascular smooth muscle of the isolated thoracic rat aorta. Evid. Based Complement. Alternat. Med. 2012 , 539475.
Dhanya, R., Arun, K.B., Syama, H.P., Nisha, P., Sundaresan, A., Kumar, T.S., Jayamurthy, P., 2014. Rutin and quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl hydrogen peroxide. Food Chem. 158, 546-554.
Du, Y., Han, J., Zhang, H., Xu, J., Jiang, L., Ge, W., 2019. Kaempferol prevents against Ang II-induced cardiac remodeling through attenuating Ang II-induced inflammation and oxidative stress. J. Cardiovasc. Pharmacol. 74, 326.
Duarte, M.C.T., Leme, E.E., Delarmelina, C., Soares, A.A., Figueira, G.M., Sartoratto, A., 2007. Activity of essential oils from Brazilian medicinal plants on Escherichia coli. J. Ethnopharmacol. 111, 197-201.
Dwivedi, P.S., Khanal, P., Gaonkar, V.P., Rasal, V.P., Patil, B.M., 2021. Identification of PTP1B regulators from Cymbopogon citratus and its enrichment analysis for diabetes mellitus. In silico Pharmacol. 9(1), 30.
Dzoyem, J.P., Hamamoto, H., Ngameni, B., Ngadjui, B.T., Sekimizu, K., 2013. Antimicrobial action mechanism of flavonoids from Dorstenia species. Drug Discov. Ther. 7, 66-72.
Ekpenyong, C.E., Akpan, E., Nyoh, A., 2015. Ethnopharmacology, phytochemistry, and biological activities of Cymbopogon citratus (DC.) Stapf extracts. Chin. J. Nat. Med. 13, 321-337.
El-Adawi, H., El-Deeb, N., 2012. Inhibitory effect of grape seed extract (GSE) on cariogenic bacteria. Planta Med. 78, PL7.
Elbatreek, M.H., Mahdi, I., Ouchari, W., Mahmoud, M.F., Sobeh, M., 2023. Current advances on the therapeutic potential of pinocembrin: An updated review. Biomed. Pharmacother. 157, 114032.
Elekofehinti, O.O., Onunkun, A.T., Olaleye, T.M., 2020. Cymbopogon citratus (DC.) Stapf mitigates ER-stress induced by streptozotocin in rats via down-regulation of GRP78 and up-regulation of Nrf2 signaling. J. Ethnopharmacol. 262, 113130.
Elmasri, W.A., Yang, T., Tran, P., Hegazy, M.-E.F., Hamood, A.N., Mechref, Y., Paré, P.W., 2015. Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus. J. Nat. Prod. 78, 2-9.
Fadli, M., Pagès, J.-M., Mezrioui, N.-E., Abbad, A., Hassani, L., 2016. Artemisia herba-alba Asso and Cymbopogon citratus (DC.) Stapf essential oils and their capability to restore antibiotics efficacy. Ind. Crops Prod. 89, 399-404.
Fan, X., Wei, W., Huang, J., Liu, X., Ci, X., 2020. Isoorientin attenuates cis-platin-induced nephrotoxicity through the inhibition of oxidative stress and apoptosis via activating the SIRT1/SIRT6/Nrf-2 pathway. Front. Pharmacol. 11, 264.
Feng, H., Cao, J., Zhang, G., Wang, Y., 2017. Kaempferol attenuates cardiac hypertrophy via regulation of ASK1/MAPK signaling pathway and oxidative stress. Planta Med. 83, 837-845.
Figueirinha, A., Paranhos, A., Pérez-Alonso, J.J., Santos-Buelga, C., Batista, M.T., 2008. Cymbopogon citratus leaves: Characterization of flavonoids by HPLC-PDA-ESI/MS/MS and an approach to their potential as a source of bioactive polyphenols. Food Chem. 110, 718-728.
Francisco, V., Figueirinha, A., Costa, G., Liberal, J., Lopes, M.C., García-Rodríguez, C., Geraldes, C.F., Cruz, M.T., Batista, M.T., 2014. Chemical characterization and anti-inflammatory activity of luteolin glycosides isolated from lemongrass. J. Funct. Foods 10, 436-443.
Garba, H.A., Mohammed, A., Ibrahim, M.A., Shuaibu, M.N., 2020. Effect of lemongrass (Cymbopogon citratus Stapf) tea in a type 2 diabetes rat model. Clin. Phytoscience 6, 1-10.
Gautam, R., Singh, M., Gautam, S., Rawat, J.K., Saraf, S.A., Kaithwas, G., 2016. Rutin attenuates intestinal toxicity induced by methotrexate linked with anti-oxidative and anti-inflammatory effects. BMC Complement. Alternat. Med. 16(1), 99.
Gentile, D., Fornai, M., Colucci, R., Pellegrini, C., Tirotta, E., Benvenuti, L., Segnani, C., Ippolito, C., Duranti, E., Virdis, A., 2018. The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. PLOS ONE 13, e0195502.
Ghosh, S., Lahiri, D., Nag, M., Dey, A., Ray, R.R., 2023. 4 - The Role of Bioactive Metabolites Synthesized by Endophytes Against Mdr Human Pathogens, in: Shah, M., Deka, D. (Eds.), Endophytic Association: What, Why and How, Developments in Applied Microbiology and Biotechnology. Academic Press, pp. 55-90.
Godwin, A., Daniel, G.A., Shadrack, D., Elom, S.A., Afua, N., Ab, K., Godsway, B., Joseph, K.G., Sackitey, N.O., Isaak, K.B., 2014. Determination of elemental, phenolic, antioxidant and flavonoid properties of lemongrass (Cymbopogon citratus Stapf). Int. Food Res. J. 21(5), 1971-1979.
Górniak, I., Bartoszewski, R., Króliczewski, J., 2019. Comprehensive review of antimicrobial activities of plant flavonoids. Phytochem. Rev. 18, 241-272.
Harwood, M., Danielewska-Nikiel, B., Borzelleca, J.F., Flamm, G.W., Williams, G.M., Lines, T.C., 2007. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem. Toxicol. 45, 2179-2205.
Hasanein, P., Emamjomeh, A., Chenarani, N., Bohlooli, M., 2020. Beneficial effects of rutin in diabetes-induced deficits in acquisition learning, retention memory and pain perception in rats. Nutr. Neurosci. 23, 563-574.
Hertel, W., Peschel, G., Ozegowski, J.-H., Müller, P.-J., 2006. Inhibitory effects of triterpenes and flavonoids on the enzymatic activity of hyaluronic acid-splitting enzymes. Arch. Pharm. 339, 313-318.
Hirazawa, S., Saito, Y., Sagano, M., Goto, M., Nakagawa-Goto, K., 2022. Chemical space expansion of flavonoids: Induction of mitotic inhibition by replacing ring B with a 10π-electron system, benzo[b]thiophene. J. Nat. Prod. 85(1), 136-147.
Hong, Y., Yin, Y., Tan, Y., Hong, K., Jiang, F., Wang, Y., 2018. Effect of quercetin on biochemical parameters in letrozole-induced polycystic ovary syndrome in rats. Trop. J. Pharm. Res. 17, 1783-1788.
Hossain, C.M., Ghosh, M.K., Satapathy, B.S., Dey, N.S., Mukherjee, B., 2014. Apigenin causes biochemical modulation, GLUT4 and Cd38 alterations to improve diabetes and to protect damages of some vital organs in experimental diabetes. Am. J. Pharmacol. Toxicol. 9, 39-52.
Huang, W., Wang, Y., Tian, W., Cui, X., Tu, P., Li, J., Shi, S., Liu, X., 2022. Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants. Antibiotics 11, 1380.
Hyung Ko, J., Gyu Kim, B., Joong-Hoon, A., 2006. Glycosylation of flavonoids with a glycosyltransferase from Bacillus cereus. FEMS Microbiol. Lett. 258, 263-268.
Ince, E., 2020. The protective effect of quercetin in the alcohol-induced liver and lymphoid tissue injuries in newborns. Mol. Biol. Rep. 47, 451-459.
Itankar, P.R., Tauqeer, M., Dalal, J.S., 2019. Toxicological and pharmacological profiling of organically and non-organically cultivated Cymbopogon citratus. J. Ayurveda Integr. Med. 10, 233-240.
Jahn, K., Handtke, S., Palankar, R., Kohler, T.P., Wesche, J., Wolff, M., Bayer, J., Wolz, C., Greinacher, A., Hammerschmidt, S., 2022. α-Hemolysin of Staphylococcus aureus impairs thrombus formation. J. Thromb. Haemost. 20, 1464-1475.
Jeong, K.-W., Lee, J.-Y., Kang, D.-I., Lee, J.-U., Shin, S.Y., Kim, Y., 2009. Screening of flavonoids as candidate antibiotics against Enterococcus faecalis. J. Nat. Prod. 72, 719-724.
Jubair, N., Rajagopal, M., Chinnappan, S., Abdullah, N.B., Fatima, A., 2021. Review on the antibacterial mechanism of plant-derived compounds against multidrug-resistant bacteria (MDR). Evid. Based Complement. Alternat. Med. 2021, e3663315.
Kaludercic, N., Deshwal, S., Di Lisa, F., 2014. Reactive oxygen species and redox compartmentalization. Front. Physiol. 5, 285.
Karami, S., Yargholi, A., Sadati Lamardi, S.N., Soleymani, S., Shirbeigi, L., 2021. A review of ethnopharmacology, phytochemistry and pharmacology of Cymbopogon species. Res. J. Pharmacogn. 8, 83-112.
Kaszubska, W., Falls, H.D., Schaefer, V.G., Haasch, D., Frost, L., Hessler, P., Kroeger, P.E., White, D.W., Jirousek, M.R., Trevillyan, J.M., 2002. Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line. Mol. Cell. Endocrinol. 195, 109-118.
Khosravi Bakhtiari, M., Sharifiyazdi, H., Nazifi, S., Ghaemi, M., Hadadipour Zarandi, M., 2021. Effects of citral on serum antioxidant status and liver genes expressions of paraoxonase 1 and nitric oxide synthase in a rat model of streptozotocin-induced diabetes mellitus. Iran J. Vet. Res. 22, 195-202.
Kianasab, M.R., Mohammadhosseini, M., Nekoei, M., Mahdavi, B., Baheri, T., 2024. Screening of the compositions of essential oils and volatiles of Perovskia abrotanoides Karel. along with antioxidant, antibacterial and cytotoxic impacts of its methanol extract. Nat. Prod. Res. 38(21), 3813-3817.
Kouassi, E.K., Coulibaly, I., Rodica, P., Pintea, A., Ouattara, S., Odagiu, A., 2017. HPLC phenolic compounds analysis and antifungal activity of extracts from Cymbopogon citratus (DC) Stapf against Fusarium graminearum and Fusarium oxysporum sp tulipae. J. Sci. Res. Rep. 14(5), 1-11.
Lee, H.N., Shin, S.A., Choo, G.S., Kim, H.J., Park, Y.S., Kim, B.S., Kim, S.K., Cho, S.D., Nam, J.S., Choi, C.S., 2018. Anti-inflammatory effect of quercetin and galangin in LPS-stimulated RAW264.7 macrophages and DNCB-induced atopic dermatitis animal models. Int. J. Mol. Med. 41, 888-898.
Li, L., Luo, W., Qian, Y., Zhu, W., Qian, J., Li, J., Jin, Y., Xu, X., Liang, G., 2019. Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses. Phytomedicine 59, 152774.
Li, Y., Zhao, Y., Tan, X., Liu, J., Zhi, Y., Yi, L., Bai, S., Du, Q., Li, Q.X., Dong, Y., 2020. Isoorientin inhibits inflammation in macrophages and endotoxemia mice by regulating glycogen synthase kinase 3β. Mediators Inflamm. 2020, 8704146.
Liang, Y., Zhang, Y., Liu, M., Han, X., Zhang, J., Zhang, X., Chu, L., 2020. Protective effect of quercetin against myocardial ischemia as a Ca2+ channel inhibitor: Involvement of inhibiting contractility and Ca2+ influx via L-type Ca2+ channels. Arch. Pharm. Res. 43, 808-820.
Lin, Q., Chen, X.-Y., Zhang, J., Yuan, Y.-L., Zhao, W., Wei, B., 2018. Upregulation of SIRT1 contributes to the cardioprotective effect of rutin against myocardial ischemia-reperfusion injury in rats. J. Funct. Foods 46, 227-236.
Liu, Y., Song, Y., Li, S., Mo, L., 2021. Cardioprotective effect of quercetin against ischemia/reperfusion injury is mediated through NO system and mitochondrial K-ATP channels. Cell J. (Yakhteh) 23, 184.
Lobiuc, A., Pavăl, N.-E., Mangalagiu, I.I., Gheorghiță, R., Teliban, G.-C., Amăriucăi-Mantu, D., Stoleru, V., 2023. Future antimicrobials: Natural and functionalized phenolics. Molecules 28, 1114.
Lu, Q., Hao, M., Wu, W., Zhang, N., Isaac, A.T., Yin, J., Zhu, X., Du, L., Yin, X., 2018. Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway. Acta Biochim. Pol. 65, 35-41.
Luo, Y., Shang, P., Li, D., 2017. Luteolin: A flavonoid that has multiple cardio-protective effects and its molecular mechanisms. Front. Pharmacol. 8(OCT), 692.
Madi, Y.F., Choucry, M.A., El-Marasy, S.A., Meselhy, M.R., El-Kashoury, E.-S.A., 2020. UPLC-Orbitrap HRMS metabolic profiling of Cymbopogon citratus cultivated in Egypt; neuroprotective effect against AlCl3-induced neurotoxicity in rats. J. Ethnopharmacol. 259, 112930.
Magotra, S., Singh, Ajeet Pal, Singh, Amar Pal, 2021a. A review on pharmacological activities of Cymbopogon citratus. Int. J. Pharm. Drug Anal. 151-157.
Mahajan, U.B., Chandrayan, G., Patil, C.R., Arya, D.S., Suchal, K., Agrawal, Y.O., Ojha, S., Goyal, S.N., 2017. The protective effect of apigenin on myocardial injury in diabetic rats mediating activation of the PPAR-γ pathway. Int. J. Mol. Sci. 18, 756.
Malik, A., Jamil, U., Butt, T.T., Waquar, S., Gan, S.H., Shafique, H., Jafar, T.H., 2019. In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model. Drug Des. Dev. Ther. 13, 1501.
Mandić, L., Sadžak, A., Strasser, V., Baranović, G., Domazet Jurašin, D., Dutour Sikirić, M., Šegota, S., 2019. Enhanced protection of biological membranes during lipid peroxidation: Study of the interactions between flavonoid-loaded mesoporous silica nanoparticles and model cell membranes. Int. J. Mol. Sci. 20, 2709.
Manzoor, M.F., Ahmad, N., Ahmed, Z., Siddique, R., Zeng, X., Rahaman, A., Muhammad Aadil, R., Wahab, A., 2019. Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives. J. Food Biochem. 43(9), e12974.
Martins, W. da S., de Araújo, J.S.F., Feitosa, B.F., Oliveira, J.R., Kotzebue, L.R.V., Agostini, D.L. da S., de Oliveira, D.L.V., Mazzetto, S.E., Cavalcanti, M.T., da Silva, A.L., 2021. Lemongrass (Cymbopogon citratus DC. Stapf) essential oil microparticles: Development, characterization, and antioxidant potential. Food Chem. 355, 129644.
Méabed, E.M.H., Abou-Sreea, A.I.B., Roby, M.H.H., 2018. Chemical analysis and giardicidal effectiveness of the aqueous extract of Cymbopogon citratus Stapf. Parasitol. Res. 117, 1745-1755.
Mechchate, H., Es-safi, I., Haddad, H., Bekkari, H., Grafov, A., Bousta, D., 2021. Combination of catechin, epicatechin, and rutin: Optimization of a novel complete antidiabetic formulation using a mixture design approach. J. Nutr. Biochem. 88, 108520.
Messaoudi, M., Rebiai, A., Sawicka, B., Atanassova, M., Ouakouak, H., Larkem, I., Egbuna, C., Awuchi, C.G., Boubekeur, S., Ferhat, M.A., Begaa, S., Benchikha, N., 2022. Effect of extraction methods on polyphenols, flavonoids, mineral elements, and biological activities of essential oil and extracts of Mentha pulegium L. Molecules 27(1), 11.
Miri, M.R., Zare, A., Saberzadeh, J., Baghban, N., Nabipour, I., Tamadon, A., 2022. Anti-lung cancer marine compounds: A review. Ther. Innov. Regul. Sci. 56(2), 191-205.
Mirzaei, M., Ladan Moghadam, A., Hakimi, L., Danaee, E., 2020. Plant growth promoting rhizobacteria (PGPR) improve plant growth, antioxidant capacity, and essential oil properties of lemongrass (Cymbopogon citratus) under water stress. Iran. J. Plant Physiol. 10, 3155-3166.
Mirzaei, R., Ranjbar, R., 2022. Hijacking host components for bacterial biofilm formation: An advanced mechanism. Int. Immunopharmacol. 103, 108471.
Mohamed, M.S., Abdelkader, K., Gomaa, H.A.M., Batubara, A.S., Gamal, M., Sayed, A.M., 2022. Mechanistic study of the antibacterial potential of the prenylated flavonoid auriculasin against Escherichia coli. Arch. Pharm. 355, 2200360.
Mohammadhosseini, M., Frezza, C., Venditti, A., Akbarzadeh, A., 2019. Ethnobotany and phytochemistry of the genus Eremostachys Bunge. Curr. Org. Chem. 23, 1828-1842.
Mohammadhosseini, M., Frezza, C., Venditti, A., Sarker, S., 2021. A systematic review on phytochemistry, ethnobotany and biological activities of the genus Bunium L. Chem. Biodivers. 18(11), e2100317.
Nayki, C., Nayki, U., Keskin Cimen, F., Kulhan, M., Yapca, O.E., Kurt, N., Bilgin Ozbek, A., 2018. The effect of rutin on ovarian ischemia-reperfusion injury in a rat model. Gynecol. Endocrinol. 34, 809-814.
Ngogang, M.P., Ernest, T., Kariuki, J., Mouliom Mouiche, M.M., Ngogang, J., Wade, A., van der Sande, M.A.B., 2021. Microbial contamination of chicken litter manure and antimicrobial resistance threat in an urban area setting in Cameroon. Antibiotics 10(1), 20.
Nordeen, S.K., Bona, B.J., Jones, D.N., Lambert, J.R., Jackson, T.A., 2013. Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin. Horm. Cancer 4, 293-300.
Oboh, G., Adefegha, S.A., Ademosun, A.O., Unu, D., 2010. Effects of hot water treatment on the phenolic phytochemicals and antioxidant activities of lemongrass (Cymbopogon citratus). Electron. J. Environ. Agric. Food Chem. 9, 503-513.
Ohemeng, K.A., Schwender, C.F., Fu, K.P., Barrett, J.F., 1993. DNA gyrase inhibitory and antibacterial activity of some flavones. Bioorg. Med. Chem. Lett. 3, 225-230.
Oladeji, O.S., Adelowo, F.E., Ayodele, D.T., Odelade, K.A., 2019. Phytochemistry and pharmacological activities of Cymbopogon citratus: A review. Sci. Afr. 6, e00137.
Olorunnisola, S.K., Asiyanbi, H.T., Hammed, A.M., Simsek, S., 2014. Biological properties of lemongrass: An overview. Int. Food Res. J. 21, 455.
Olukunle, O.F., Adenola, O.J., 2019. Comparative antimicrobial activity of lemongrass (Cymbopogon citratus) and garlic (Allium sativum) extracts on Salmonella typhi. J. Adv. Med. Pharm. Sci. 1-9.
Orrego, R., Leiva, E., Cheel, J., 2009. Inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus (lemongrass) on human low density lipoprotein oxidation. Molecules 14, 3906-3913.
Oteiza, P.I., Erlejman, A.G., Verstraeten, S.V., Keen, C.L., Fraga, C.G., 2005. Flavonoid-membrane interactions: A protective role of flavonoids at the membrane surface? Clin. Dev. Immunol. 12, 19-25.
Ousaaid, D., Laaroussi, H., Bakour, M., El Ghouizi, A., El Menyiy, N., Lyoussi, B., El Arabi, I., 2022. Effect of a combination of Rosa canina fruits and apple cider vinegar against hydrogen peroxide-induced toxicity in experimental animal models. J. Food Qual. 2022, e7381378.
Owumi, S.E., Lewu, D.O., Arunsi, U.O., Oyelere, A.K., 2021. Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis. Hum. Exp. Toxicol. 40, 1656-1672.
Pan, D., Machado, L., Bica, C.G., Machado, A.K., Steffani, J.A., Cadoná, F.C., 2022. In vitro evaluation of antioxidant and anticancer activity of lemongrass (Cymbopogon citratus (D.C.) Stapf). Nutr. Cancer 74, 1474-1488.
Pan, D., Machado, L., Bica, C.G., Machado, A.K., Steffani, J.A., Cadoná, F.C., 2021. In vitro evaluation of antioxidant and anticancer activity of lemongrass (Cymbopogon citratus (D.C.) Stapf). Nutr. Cancer 74(4), 1474-1488.
Park, M.J., Lee, E.K., Heo, H.-S., Kim, M.-S., Sung, B., Kim, M.K., Lee, J., Kim, N.D., Anton, S., Choi, J.S., 2009. The anti-inflammatory effect of kaempferol in aged kidney tissues: The involvement of nuclear factor- kappaB via nuclear factor-inducing kinase/IκB kinase and mitogen-activated protein kinase pathways. J. Med. Food 12, 351-358.
Pearson, J.P., Feldman, M., Iglewski, B.H., Prince, A., 2000. Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect. Immun. 68, 4331-4334.
Poudel, B., Nepali, S., Xin, M., Ki, H.-H., Kim, Y.-H., Kim, D.-K., Lee, Y.-M., 2015. Flavonoids from Triticum aestivum inhibit adipogenesis in 3T3-L1 cells by upregulating the insig pathway. Mol. Med. Rep. 12(2), 3139-3145.
Qi, Y., Ying, Y., Zou, J., Fang, Q., Yuan, X., Cao, Y., Cai, Y., Fu, S., 2020. Kaempferol attenuates cisplatin-induced cardiac injury via inhibiting STING/NF-κB-mediated inflammation. Am. J. Transl. Res. 12, 8007.
Qian, W., Liu, M., Fu, Y., Zhang, J., Liu, W., Li, J., Li, X., Li, Y., Wang, T., 2020. Antimicrobial mechanism of luteolin against Staphylococcus aureus and Listeria monocytogenes and its antibiofilm properties. Microbiol. Pathog. 142, 104056.
Rabbani, S., Devi, K., Khanam, S., Zahra, N., 2006. Citral, a component of lemongrass oil inhibits the clastogenic effect of nickel chloride in mouse micronucleus test system. Pak. J. Pharm. Sci. 19, 108-113.
Rogerio, A.P., Dora, C.L., Andrade, E.L., Chaves, J.S., Silva, L.F., Lemos-Senna, E., Calixto, J.B., 2010. Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacol. Res. 61, 288-297.
Roy, P.K., Park, S.-H., Song, M.G., Park, S.Y., 2022. Antimicrobial efficacy of quercetin against Vibrio parahaemolyticus biofilm on food surfaces and downregulation of virulence genes. Polymers 14, 3847.
Sahal, G., Woerdenbag, H.J., Hinrichs, W.L.J., Visser, A., Tepper, P.G., Quax, W.J., van der Mei, H.C., Bilkay, I.S., 2020. Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm formation by Candida tropicalis isolates; An in vitro study. J. Ethnopharmacol. 246, 112188.
Saini, R., Sharma, N., Oladeji, O.S., Sourirajan, A., Dev, K., Zengin, G., El-Shazly, M., Kumar, V., 2022. Traditional uses, bioactive composition, pharmacology, and toxicology of Phyllanthus emblica fruits: A comprehensive review. J. Ethnopharmacol. 282, 114570.
Salaria, D., Rolta, R., Sharma, N., Patel, C.N., Ghosh, A., Dev, K., Sourirajan, A., Kumar, V., 2021. In vitro and in silico antioxidant and anti-inflammatory potential of essential oil of Cymbopogon citratus (DC.) Stapf. of North-Western Himalaya. J. Biomol. Struct. Dyn. 1-15.
Salatin, S., Bazmani, A., Shahi, S., Naghili, B., Memar, M.Y., Dizaj, S.M., 2022. Antimicrobial benefits of flavonoids and their nanoformulations. Curr. Pharm. Des. 28, 1419-1432.
Salvado, L., Palomer, X., Barroso, E., Vázquez-Carrera, M., 2015. Targeting endoplasmic reticulum stress in insulin resistance. Trends Endocrinol. Metab. 26, 438-448.
Seukep, A.J., Nembu, N.E., Mbuntcha, H.G., Kuete, V., 2023. Chapter Two-Bacterial Drug Resistance Towards Natural Products, in: Kuete, V. (Ed.), Advances in Botanical Research, African Flora to Fight Bacterial Resistance, Part I: Standards for the Activity of Plant-Derived Products. Academic Press, pp. 21-45.
Sezik, E., Aslan, M., Yesilada, E., Ito, S., 2005. Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques. Life Sci. 76, 1223-1238.
Shah, G., Shri, R., Panchal, V., Sharma, N., Singh, B., Mann, A.S., 2011. Scientific basis for the therapeutic use of Cymbopogon citratus, Stapf (Lemongrass). J. Adv. Pharm. Technol. Res. 2, 3.
Shao, L., Shao, Y., Yuan, Y., 2021. Pinocembrin flavanone inhibits cell viability in PC-3 human prostate cancer by inducing cellular apoptosis, ROS production, and cell cycle arrest. Acta Pharm. 71, 669-678.
Sharifi-Rad, J., Quispe, C., Imran, M., Rauf, A., Nadeem, M., Gondal, T.A., Ahmad, B., Atif, M., Mubarak, M.S., Sytar, O., Zhilina, O.M., Garsiya, E.R., Smeriglio, A., Trombetta, D., Pons, D.G., Martorell, M., Cardoso, S.M., Razis, A.F.A., Sunusi, U., Kamal, R.M., Rotariu, L.S., Butnariu, M., Docea, A.O., Calina, D., 2021. Genistein: An integrative overview of its mode of action, pharmacological properties, and health benefits. Oxid. Med. Cell. Longev. 2021, e3268136.
Sharma, D., Tekade, R.K., Kalia, K., 2020. Kaempferol in ameliorating diabetes-induced fibrosis and renal damage: An in vitro and in vivo study in diabetic nephropathy mice model. Phytomedicine 76, 153235.
Sheth, P.A., Pawar, A.T., Mote, C.S., More, C., 2021. Antianemic activity of polyherbal formulation, Raktavardhak Kadha, against phenylhydrazine-induced anemia in rats. J. Ayurveda Integr. Med. 12(2), 340-345.
Silva, F.C., Bramatti, I.C., Toledo, A.G., Salles, F.M., Itinose, A.M., Marek, C.B., 2017. Antihyperglycemic effect of quercetin in ovariectomized rats treated with tamoxifen. J. Med. Food 20, 235-242.
Simões, D.M., Malheiros, J., Antunes, P.E., Figueirinha, A., Cotrim, M.D., Fonseca, D.A., 2020. Vascular activity of infusion and fractions of Cymbopogon citratus (DC) Stapf. in human arteries. J. Ethnopharmacol. 258, 112947.
Soliman, W.S., Salaheldin, S., Amer, H.M., 2017. Chemical composition evaluation of Egyptian lemongrass, Cymbopogon citratus, essential oil. Int. J. Sci. Eng. Res, 8(11), 630-634.
Son, M., Oh, S., Choi, J., Jang, J.T., Choi, C.H., Park, K.Y., Son, K.H., Byun, K., 2019. Attenuation of inflammation and leptin resistance by pyrogallol-phloroglucinol-6,6-bieckol in the brain of obese animal models. Nutrients 11, 2773.
Son, M., Oh, S., Jang, J.T., Son, K.H., Byun, K., 2021. Pyrogallol-phloroglucinol-6,6-bieckol attenuates high-fat diet-induced hypertension by modulating endothelial-to-mesenchymal transition in the aorta of mice. Oxid. Med. Cell. Longev. 2021, 8869085.
Soromou, L.W., Zhang, Y., Cui, Y., Wei, M., Chen, N., Yang, X., Huo, M., Baldé, A., Guan, S., Deng, X., Wang, D., 2013. Subinhibitory concentrations of pinocembrin exert anti-Staphylococcus aureus activity by reducing α-toxin expression. J. Appl. Microbiol. 115, 41-49.
Sousa, R., Figueirinha, A., Batista, M.T., Pina, M.E., 2021. Formulation effects in the antioxidant activity of extract from the leaves of Cymbopogon citratus (DC) Stapf. Molecules 26, 4518.
Strawa, J.W., Jakimiuk, K., Pawlikowska-Pawlęga, B., Gruszecki, W.I., Kapral-Piotrowska, J., Wiater, A., Tomczyk, M., 2023. Polar localization of new flavonoids from aerial parts of Scleranthus perennis and Hottonia palustris and their modulatory action on lipid membranes properties. Biochim. Biophys. Acta Biomembr. 1865, 184142.
Subramaniam, G., Yew, X.Y., Sivasamugham, L.A., 2020. Antibacterial activity of Cymbopogon citratus against clinically important bacteria. South Afr. J. Chem. Eng. 34, 26-30.
Sugita-Konishi, Y., Hara-Kudo, Y., Amano, F., Okubo, T., Aoi, N., Iwaki, M., Kumagai, S., 1999. Epigallocatechin gallate and gallocatechin gallate in green tea catechins inhibit extracellular release of Vero toxin from enterohemorrhagic Escherichia coli O157:H7. Biochim. Biophys. Acta Gen. Subjects 1472, 42-50.
Sun, X., Sun, G., Wang, M., Xiao, J., Sun, X.-B., 2011. Protective effects of cynaroside against H2O2-induced apoptosis in H9c2 cardiomyoblasts. J. Cell. Biochem. 112, 2019-2029.
Suriyanarayanan, B., Shanmugam, K., Santhosh, R.S., 2013. Synthetic quercetin inhibits mycobacterial growth possibly by interacting with DNA gyrase. Rom. Biotechnol. Lett. 18, 8587-8593.
Szekalska, M., Sosnowska, K., Tomczykowa, M., Winnicka, K., Kasacka, I., Tomczyk, M., 2020. In vivo anti-inflammatory and anti-allergic activities of cynaroside evaluated by using hydrogel formulations. Biomed. Pharm. Ther. 121, 109681.
Tang, F., Li, L., Meng, X.-M., Li, B., Wang, C.-Q., Wang, S.-Q., Wang, T.-L., Tian, Y.-M., 2019. Inhibition of alpha-hemolysin expression by resveratrol attenuates Staphylococcus aureus virulence. Microb. Pathog. 127, 85-90.
Tauffenberger, A., Magistretti, P.J., 2021. Reactive oxygen species: Beyond their reactive behavior. Neurochem. Res. 1-11.
Tavares, F., Costa, G., Francisco, V., Liberal, J., Figueirinha, A., Lopes, M.C., Cruz, M.T., Batista, M.T., 2015. Cymbopogon citratus industrial waste as a potential source of bioactive compounds: Bioactive compounds from Cymbopogon citratus industrial waste. J. Sci. Food Agric. 95, 2652-2659.
Thagriki, D.S., 2022. Quercetin and its derivatives are potent inhibitors of the dengue virus. Trends Phytochem. Res. 6(1), 70-85.
Thangaiyan, R., Robert, B.M., Arjunan, S., Govindasamy, K., Nagarajan, R.P., 2018. Preventive effect of apigenin against isoproterenol-induced apoptosis in cardiomyoblasts. J. Biochem. Mol. Toxicol. 32, e22213.
Topal, İ., Bilgin, A.Ö., Çimen, F.K., Kurt, N., Süleyman, Z., Bilgin, Y., Özçiçek, A., Altuner, D., 2018. The effect of rutin on cisplatin-induced oxidative cardiac damage in rats. Anatol. J. Cardiol. 20, 136.
Touil, Y.S., Seguin, J., Scherman, D., Chabot, G.G., 2011. Improved antiangiogenic and antitumor activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice. Cancer Chemother. Pharmacol. 68, 445-455.
Van, L.V., Pham, E.C., Nguyen, C.V., Duong, N.T.N., Le Thi, T.V., Truong, T.N., 2022. In vitro and In vivo antidiabetic activity, isolation of flavonoids, and in silico molecular docking of stem extract of Merremia tridentata (L.). Biomed. Pharm. Ther. 146, 112611.
Vaou, N., Stavropoulou, E., Voidarou, C. (Chrysa), Tsakris, Z., Rozos, G., Tsigalou, C., Bezirtzoglou, E., 2022. Interactions between medical plant-derived bioactive compounds: Focus on antimicrobial combination effects. Antibiotics 11, 1014.
Veiko, A.G., Olchowik-Grabarek, E., Sekowski, S., Roszkowska, A., Lapshina, E.A., Dobrzynska, I., Zamaraeva, M., Zavodnik, I.B., 2023. Antimicrobial activity of quercetin, naringenin and catechin: Flavonoids inhibit Staphylococcus aureus-induced hemolysis and modify membranes of bacteria and erythrocytes. Molecules 28, 1252.
Veiko, A.G., Sekowski, S., Lapshina, E.A., Wilczewska, A.Z., Markiewicz, K.H., Zamaraeva, M., Zhao, H., Zavodnik, I.B., 2020. Flavonoids modulate liposomal membrane structure, regulate mitochondrial membrane permeability and prevent erythrocyte oxidative damage. Biochim. Biophys. Acta Biomembr. 1862, 183442.
Vishwakarma, A., Singh, T.U., Rungsung, S., Kumar, T., Kandasamy, A., Parida, S., Lingaraju, M.C., Kumar, A., Kumar, A., Kumar, D., 2018. Effect of kaempferol pretreatment on myocardial injury in rats. Cardiovasc. Toxicol. 18, 312-328.
Wang, B., Liu, D., Zhu, Q., Li, M., Chen, H., Guo, Y., Fan, L., Yue, L., Li, L., Zhao, M., 2016. Rutin ameliorates kidney interstitial fibrosis in rats with obstructive nephropathy. Int. Immunopharmacol. 35, 77-84.
Wang, J., Liu, Y.-T., Xiao, L., Zhu, L., Wang, Q., Yan, T., 2014. Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway. Inflammation 37, 2085-2090.
Wrońska, N., Szlaur, M., Zawadzka, K., Lisowska, K., 2022. The synergistic effect of triterpenoids and flavonoids—new approaches for treating bacterial infections? Molecules 27, 847.
Wu, B., Song, H., Fan, M., You, F., Zhang, L., Luo, J., Li, J., Wang, L., Li, C., Yuan, M., 2020. Luteolin attenuates sepsis-induced myocardial injury by enhancing autophagy in mice. Int. J. Mol. Med. 45, 1477-1487.
Wu, Q., Li, W., Zhao, J., Sun, W., Yang, Q., Chen, C., Xia, P., Zhu, J., Zhou, Y., Huang, G., 2021. Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation. Biomed. Pharm. Ther. 137, 111308.
Xianchu, L., Lan, Z., Ming, L., Yanzhi, M., 2018. Protective effects of rutin on lipopolysaccharide-induced heart injury in mice. J. Toxicol. Sci. 43, 329-337.
Xiao, C., Xia, M.-L., Wang, J., Zhou, X.-R., Lou, Y.-Y., Tang, L.-H., Zhang, F.-J., Yang, J.-T., Qian, L.-B., 2019. Luteolin attenuates cardiac ischemia/reperfusion injury in diabetic rats by modulating Nrf2 antioxidative function. Oxid. Med. Cell. Longev. 20199, 2719252.
Yuan, L., Han, X., Li, W., Ren, D., Yang, X., 2016. Isoorientin prevents hyperlipidemia and liver injury by regulating lipid metabolism, antioxidant capability, and inflammatory cytokine release in high-fructose-fed mice. J. Agric. Food Chem. 64, 2682-2689.
Zaman, F.Q., Jaffel, K., Abdelmageed, A.H.A., 2022. The effects of post-harvest drying period on the yield and chemical composition of leaf essential oil from Cymbopogon citratus (DC.) Stapf. J. Essent. Oil Bear. Plants 25, 571-580.
Zamboni, F., Wong, C.K., Collins, M.N., 2023. Hyaluronic acid association with bacterial, fungal and viral infections: Can hyaluronic acid be used as an antimicrobial polymer for biomedical and pharmaceutical applications? Bioact. Mater. 19, 458-473.
Zhai, K., Mazurakova, A., Koklesova, L., Kubatka, P., Büsselberg, D., 2021. Flavonoids synergistically enhance the anti-glioblastoma effects of chemotherapeutic drugs. Biomolecules 11, 1841.
Zhang, L., Kong, Y., Wu, D., Zhang, H., Wu, J., Chen, J., Ding, J., Hu, L., Jiang, H., Shen, X., 2008. Three flavonoids targeting the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: Crystal structure characterization with enzymatic inhibition assay. Protein Sci. 17, 1971-1978.
Zhang, L., Zhu, X.-Z., Badamjav, R., Zhang, J.-Z., Kou, J.-P., Yu, B.-Y., Li, F., 2022. Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways. Eur. J. Pharmacol. 174748.
Zhou, D.-C., Zheng, G., Jia, L.-Y., He, X., Zhang, C.-F., Wang, C.-Z., Yuan, C.-S., 2021. Comprehensive evaluation on anti-inflammatory and anti-angiogenic activities in vitro of fourteen flavonoids from Daphne Genkwa based on the combination of efficacy coefficient method and principal component analysis. J. Ethnopharmacol. 268, 113683.
Zhou, P., Tang, D., Zou, J., Wang, X., 2022. An alternative strategy for enhancing stability and antimicrobial activity of catechins by natural deep eutectic solvents. LWT 153, 112558.
Zhumakanova, B.S., Korona-Głowniak, I., Skalicka-Woźniak, K., Ludwiczuk, A., Baj, T., Wojtanowski, K.K., Józefczyk, A., Zhaparkulova, K.A., Sakipova, Z.B., Malm, A., 2021. Phytochemical fingerprinting and in vitro antimicrobial and antioxidant activity of the aerial parts of Thymus marschallianus Willd. and Thymus seravschanicus Klokov growing widely in southern Kazakhstan. Molecules 26, 3193.
Ziqubu, K., Muller, C.J.F., Dludla, P.V., Mthembu, S.X.H., Obonye, N., Louw, J., Kappo, A.P., Silvestri, S., Orlando, P., Tiano, L., Mazibuko-Mbeje, S.E., 2020. Impact of isoorientin on metabolic activity and lipid accumulation in differentiated adipocytes. Molecules 25, 1773.
Ziyan, L., Yongmei, Z., Nan, Z., Ning, T., Baolin, L., 2007. Evaluation of the anti-inflammatory activity of luteolin in experimental animal models. Planta Med. 73, 221-226.
Aboagye, G., Tuah, B., Bansah, E., Tettey, C., Hunkpe, G., 2021. Comparative evaluation of antioxidant properties of lemongrass and other tea brands. Sci. Afr. 11, e00718.
Agarwal, H., Kumar, S.V., Rajeshkumar, S., 2021. Antidiabetic effect of silver nanoparticles synthesized using lemongrass (Cymbopogon citratus) through conventional heating and microwave irradiation approach. J. Microbiol. Biotechnol. Food Sci. 2021, 371-376.
Akinwunmi, O.A., Adekeye, D.K., Olagboye, S.A., 2020. Phytochemical quantification, in vitro antioxidant and antidiabetic potentials of methanol and dichloromethane extracts of Triclisia subcordata (Oliv) leaves. Trends Phytochem. Res. 4(1), 17-24.
Al Aboody, M.S., Mickymaray, S., 2020. Anti-fungal efficacy and mechanisms of flavonoids. Antibiotics 9, 45.
AlDrak, N., Abudawood, M., Hamed, S.S., Ansar, S., 2018. Effect of rutin on proinflammatory cytokines and oxidative stress in toxin-mediated hepatotoxicity. Toxin Rev. 37, 223-230.
Alekhya Sita, G.J., Gowthami, M., Srikanth, G., Krishna, M.M., Rama Sireesha, K., Sajjarao, M., Nagarjuna, K., Nagarjuna, M., Chinnaboina, G.K., Mishra, A., 2019. Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/HO-1 pathway. IUBMB Life 71, 1041-1047.
Ali, A.A.-M., Mansour, A.B., Attia, S.A., 2021. The potential protective role of apigenin against oxidative damage induced by nickel oxide nanoparticles in liver and kidney of male Wistar rat, Rattus norvegicus. Environ. Sci. Pollut. Res. 28, 27577-27592.
Alías-Villegas, C., Fuentes-Romero, F., Cuéllar, V., Navarro-Gómez, P., Soto, M.J., Vinardell, J.-M., Acosta-Jurado, S., 2022. Surface motility regulation of Sinorhizobium fredii HH103 by plant flavonoids and the NodD1, TtsI, NolR, and MucR1 symbiotic bacterial regulators. Int. J. Mol. Sci. 23, 7698.
Alkhalidy, H., Moore, W., Wang, Y., Luo, J., McMillan, R.P., Zhen, W., Zhou, K., Liu, D., 2018. The flavonoid kaempferol ameliorates streptozotocin-induced diabetes by suppressing hepatic glucose production. Molecules 23, 2338.
Alshehri, A.S., 2021. Kaempferol attenuates diabetic nephropathy in streptozotocin-induced diabetic rats by a hypoglycaemic effect and concomitant activation of the Nrf-2/Ho-1/antioxidants axis. Arch. Physiol. Biochem. 129(4), 984-997.
Altunayar-Unsalan, C., Unsalan, O., Mavromoustakos, T., 2022. Insights into molecular mechanism of action of citrus flavonoids hesperidin and naringin on lipid bilayers using spectroscopic, calorimetric, microscopic and theoretical studies. J. Mol. Liq. 347, 118411.
Anandan, S., Urooj, A., 2021. Hypoglycemic effects of apigenin from Morus indica in streptozotocin-induced diabetic rats. Int. J. Cur. Res. Rev. 13, 100.
Arora, A., Byrem, T.M., Nair, M.G., Strasburg, G.M., 2000. Modulation of liposomal membrane fluidity by flavonoids and isoflavonoids. Arch. Biochem. Biophys. 373, 102-109.
Awolola, G.V., Koorbanally, N.A., Chenia, H., Shode, F.O., Baijnath, H., 2014. Antibacterial and anti-biofilm activity of flavonoids and triterpenes isolated from the extracts of Ficus sansibarica Warb. subsp. sansibarica (Moraceae) extracts. Afr. J. Tradit. Complement. Alternat. Med. 11, 124-131.
Azimi, A., Eidi, A., Mortazavi, P., Rohani, A.H., 2021. Protective effect of apigenin on ethylene glycol-induced urolithiasis via attenuating oxidative stress and inflammatory parameters in adult male Wistar rats. Life Sci. 279, 119641.
Bailly, C., 2021. Bioactive biflavonoids from Wikstroemia indica (L.) C.A. Mey. (Thymelaeaceae): A review. Trends Phytochem. Res. 5(4), 190-198.
Barut, E.N., Engin, S., Saygın, İ., Kaya-Yasar, Y., Arici, S., Sezen, S.F., 2021. Alpha-lipoic acid: A promising adjuvant for nonsteroidal anti-inflammatory drugs therapy with improved efficacy and gastroprotection. Drug Dev. Res. 82, 844-851.
Bibens, L., Becker, J.-P., Dassonville-Klimpt, A., Sonnet, P., 2023. A review of fatty acid biosynthesis enzyme inhibitors as promising antimicrobial drugs. Pharmaceuticals 16, 425.
Biharee, A., Sharma, A., Kumar, A., Jaitak, V., 2020. Antimicrobial flavonoids as a potential substitute for overcoming antimicrobial resistance. Fitoterapia 146, 104720.
Boeira, C.P., Piovesan, N., Soquetta, M.B., Flores, D.C.B., Lucas, B.N., Rosa, C.S. da, Terra, N.N., 2018. Extraction of bioactive compounds of lemongrass, antioxidant activity and evaluation of antimicrobial activity in fresh chicken sausage. Cienc. Rural 48, e20180477.
Borges, P.H.O., Pedreiro, S., Baptista, S.J., Geraldes, C.F.G.C., Batista, M.T., Silva, M.M.C., Figueirinha, A., 2021. Inhibition of α-glucosidase by flavonoids of Cymbopogon citratus (DC) Stapf. J. Ethnopharmacol. 280, 114470.
Campos, J., Schmeda-Hirschmann, G., Leiva, E., Guzmán, L., Orrego, R., Fernández, P., González, M., Radojkovic, C., Zuñiga, F.A., Lamperti, L., 2014. Lemon grass (Cymbopogon citratus (DC) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein. Food Chem. 151, 175-181.
Caner, A., Onal, M.G., Silici, S., 2021. The effect of bee bread (Perga) with chemotherapy on MDA-MB-231 cells. Mol. Biol. Rep. 48, 2299-2306.
Carbajal, D., Casaco, A., Arruzazabala, L., Gonzalez, R., Tolon, Z., 1989. Pharmacological study of Cymbopogon citratus leaves. J. Ethnopharmacol. 25, 103-107.
Chahar, M.K., Sharma, N., Dobhal, M.P., Joshi, Y.C., 2011. Flavonoids: A versatile source of anticancer drugs. Pharmacogn. Rev. 5, 1-12.
Chen, L., Tian, G., Tang, W., Luo, W., Liu, P., Ma, Z., 2016. Protective effect of luteolin on streptozotocin-induced diabetic renal damage in mice via the regulation of RIP140/NF-κB pathway and insulin signalling pathway. J. Funct. Foods 22, 93-100.
Chen, X., Qian, J., Wang, L., Li, J., Zhao, Y., Han, J., Khan, Z., Chen, X., Wang, J., Liang, G., 2018. Kaempferol attenuates hyperglycemia-induced cardiac injuries by inhibiting inflammatory responses and oxidative stress. Endocrine 60, 83-94.
Chen, Y., Zeng, H., Tian, J., Ban, X., Ma, B., Wang, Y., 2013, 2022. Antifungal mechanism of essential oil from Anethum graveolens seeds against Candida albicans. J. Med. Microbiol. 62, 1175-1183.
Comalada, M., Camuesco, D., Sierra, S., Ballester, I., Xaus, J., Gálvez, J., Zarzuelo, A., 2005. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-κB pathway. Eur. J. Immunol. 35, 584-592.
Costa, G., Ferreira, J.P., Vitorino, C., Pina, M.E., Sousa, J.J., Figueiredo, I.V., Batista, M.T., 2016a. Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agents. J. Ethnopharmacol. 178, 222-228.
Costa, G., Grangeia, H., Figueirinha, A., Figueiredo, I.V., Batista, M.T., 2016b. Influence of harvest date and material quality on polyphenolic content and antioxidant activity of Cymbopogon citratus infusion. Ind. Crops Prod. 83, 738-745.
Cotin, S., Calliste, C.-A., Mazeron, M.-C., Hantz, S., Duroux, J.-L., Rawlinson, W.D., Ploy, M.-C., Alain, S., 2012. Eight flavonoids and their potential as inhibitors of human cytomegalovirus replication. Antiviral Res. 96, 181-186.
Darabi, P., Khazali, H., Mehrabani Natanzi, M., 2020. Therapeutic potentials of the natural plant flavonoid apigenin in polycystic ovary syndrome in rat model: Via modulation of pro-inflammatory cytokines and antioxidant activity. Gynecol. Endocrinol. 36, 582-587.
Delehanty, J.B., Johnson, B.J., Hickey, T.E., Pons, T., Ligler, F.S., 2007. Binding and neutralization of lipopolysaccharides by plant proanthocyanidins. J. Nat. Prod. 70, 1718-1724.
Devi, R.C., Sim, S.M., Ismail, R., 2012. Effect of Cymbopogon citratus and citral on vascular smooth muscle of the isolated thoracic rat aorta. Evid. Based Complement. Alternat. Med. 2012 , 539475.
Dhanya, R., Arun, K.B., Syama, H.P., Nisha, P., Sundaresan, A., Kumar, T.S., Jayamurthy, P., 2014. Rutin and quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl hydrogen peroxide. Food Chem. 158, 546-554.
Du, Y., Han, J., Zhang, H., Xu, J., Jiang, L., Ge, W., 2019. Kaempferol prevents against Ang II-induced cardiac remodeling through attenuating Ang II-induced inflammation and oxidative stress. J. Cardiovasc. Pharmacol. 74, 326.
Duarte, M.C.T., Leme, E.E., Delarmelina, C., Soares, A.A., Figueira, G.M., Sartoratto, A., 2007. Activity of essential oils from Brazilian medicinal plants on Escherichia coli. J. Ethnopharmacol. 111, 197-201.
Dwivedi, P.S., Khanal, P., Gaonkar, V.P., Rasal, V.P., Patil, B.M., 2021. Identification of PTP1B regulators from Cymbopogon citratus and its enrichment analysis for diabetes mellitus. In silico Pharmacol. 9(1), 30.
Dzoyem, J.P., Hamamoto, H., Ngameni, B., Ngadjui, B.T., Sekimizu, K., 2013. Antimicrobial action mechanism of flavonoids from Dorstenia species. Drug Discov. Ther. 7, 66-72.
Ekpenyong, C.E., Akpan, E., Nyoh, A., 2015. Ethnopharmacology, phytochemistry, and biological activities of Cymbopogon citratus (DC.) Stapf extracts. Chin. J. Nat. Med. 13, 321-337.
El-Adawi, H., El-Deeb, N., 2012. Inhibitory effect of grape seed extract (GSE) on cariogenic bacteria. Planta Med. 78, PL7.
Elbatreek, M.H., Mahdi, I., Ouchari, W., Mahmoud, M.F., Sobeh, M., 2023. Current advances on the therapeutic potential of pinocembrin: An updated review. Biomed. Pharmacother. 157, 114032.
Elekofehinti, O.O., Onunkun, A.T., Olaleye, T.M., 2020. Cymbopogon citratus (DC.) Stapf mitigates ER-stress induced by streptozotocin in rats via down-regulation of GRP78 and up-regulation of Nrf2 signaling. J. Ethnopharmacol. 262, 113130.
Elmasri, W.A., Yang, T., Tran, P., Hegazy, M.-E.F., Hamood, A.N., Mechref, Y., Paré, P.W., 2015. Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus. J. Nat. Prod. 78, 2-9.
Fadli, M., Pagès, J.-M., Mezrioui, N.-E., Abbad, A., Hassani, L., 2016. Artemisia herba-alba Asso and Cymbopogon citratus (DC.) Stapf essential oils and their capability to restore antibiotics efficacy. Ind. Crops Prod. 89, 399-404.
Fan, X., Wei, W., Huang, J., Liu, X., Ci, X., 2020. Isoorientin attenuates cis-platin-induced nephrotoxicity through the inhibition of oxidative stress and apoptosis via activating the SIRT1/SIRT6/Nrf-2 pathway. Front. Pharmacol. 11, 264.
Feng, H., Cao, J., Zhang, G., Wang, Y., 2017. Kaempferol attenuates cardiac hypertrophy via regulation of ASK1/MAPK signaling pathway and oxidative stress. Planta Med. 83, 837-845.
Figueirinha, A., Paranhos, A., Pérez-Alonso, J.J., Santos-Buelga, C., Batista, M.T., 2008. Cymbopogon citratus leaves: Characterization of flavonoids by HPLC-PDA-ESI/MS/MS and an approach to their potential as a source of bioactive polyphenols. Food Chem. 110, 718-728.
Francisco, V., Figueirinha, A., Costa, G., Liberal, J., Lopes, M.C., García-Rodríguez, C., Geraldes, C.F., Cruz, M.T., Batista, M.T., 2014. Chemical characterization and anti-inflammatory activity of luteolin glycosides isolated from lemongrass. J. Funct. Foods 10, 436-443.
Garba, H.A., Mohammed, A., Ibrahim, M.A., Shuaibu, M.N., 2020. Effect of lemongrass (Cymbopogon citratus Stapf) tea in a type 2 diabetes rat model. Clin. Phytoscience 6, 1-10.
Gautam, R., Singh, M., Gautam, S., Rawat, J.K., Saraf, S.A., Kaithwas, G., 2016. Rutin attenuates intestinal toxicity induced by methotrexate linked with anti-oxidative and anti-inflammatory effects. BMC Complement. Alternat. Med. 16(1), 99.
Gentile, D., Fornai, M., Colucci, R., Pellegrini, C., Tirotta, E., Benvenuti, L., Segnani, C., Ippolito, C., Duranti, E., Virdis, A., 2018. The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. PLOS ONE 13, e0195502.
Ghosh, S., Lahiri, D., Nag, M., Dey, A., Ray, R.R., 2023. 4 - The Role of Bioactive Metabolites Synthesized by Endophytes Against Mdr Human Pathogens, in: Shah, M., Deka, D. (Eds.), Endophytic Association: What, Why and How, Developments in Applied Microbiology and Biotechnology. Academic Press, pp. 55-90.
Godwin, A., Daniel, G.A., Shadrack, D., Elom, S.A., Afua, N., Ab, K., Godsway, B., Joseph, K.G., Sackitey, N.O., Isaak, K.B., 2014. Determination of elemental, phenolic, antioxidant and flavonoid properties of lemongrass (Cymbopogon citratus Stapf). Int. Food Res. J. 21(5), 1971-1979.
Górniak, I., Bartoszewski, R., Króliczewski, J., 2019. Comprehensive review of antimicrobial activities of plant flavonoids. Phytochem. Rev. 18, 241-272.
Harwood, M., Danielewska-Nikiel, B., Borzelleca, J.F., Flamm, G.W., Williams, G.M., Lines, T.C., 2007. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem. Toxicol. 45, 2179-2205.
Hasanein, P., Emamjomeh, A., Chenarani, N., Bohlooli, M., 2020. Beneficial effects of rutin in diabetes-induced deficits in acquisition learning, retention memory and pain perception in rats. Nutr. Neurosci. 23, 563-574.
Hertel, W., Peschel, G., Ozegowski, J.-H., Müller, P.-J., 2006. Inhibitory effects of triterpenes and flavonoids on the enzymatic activity of hyaluronic acid-splitting enzymes. Arch. Pharm. 339, 313-318.
Hirazawa, S., Saito, Y., Sagano, M., Goto, M., Nakagawa-Goto, K., 2022. Chemical space expansion of flavonoids: Induction of mitotic inhibition by replacing ring B with a 10π-electron system, benzo[b]thiophene. J. Nat. Prod. 85(1), 136-147.
Hong, Y., Yin, Y., Tan, Y., Hong, K., Jiang, F., Wang, Y., 2018. Effect of quercetin on biochemical parameters in letrozole-induced polycystic ovary syndrome in rats. Trop. J. Pharm. Res. 17, 1783-1788.
Hossain, C.M., Ghosh, M.K., Satapathy, B.S., Dey, N.S., Mukherjee, B., 2014. Apigenin causes biochemical modulation, GLUT4 and Cd38 alterations to improve diabetes and to protect damages of some vital organs in experimental diabetes. Am. J. Pharmacol. Toxicol. 9, 39-52.
Huang, W., Wang, Y., Tian, W., Cui, X., Tu, P., Li, J., Shi, S., Liu, X., 2022. Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants. Antibiotics 11, 1380.
Hyung Ko, J., Gyu Kim, B., Joong-Hoon, A., 2006. Glycosylation of flavonoids with a glycosyltransferase from Bacillus cereus. FEMS Microbiol. Lett. 258, 263-268.
Ince, E., 2020. The protective effect of quercetin in the alcohol-induced liver and lymphoid tissue injuries in newborns. Mol. Biol. Rep. 47, 451-459.
Itankar, P.R., Tauqeer, M., Dalal, J.S., 2019. Toxicological and pharmacological profiling of organically and non-organically cultivated Cymbopogon citratus. J. Ayurveda Integr. Med. 10, 233-240.
Jahn, K., Handtke, S., Palankar, R., Kohler, T.P., Wesche, J., Wolff, M., Bayer, J., Wolz, C., Greinacher, A., Hammerschmidt, S., 2022. α-Hemolysin of Staphylococcus aureus impairs thrombus formation. J. Thromb. Haemost. 20, 1464-1475.
Jeong, K.-W., Lee, J.-Y., Kang, D.-I., Lee, J.-U., Shin, S.Y., Kim, Y., 2009. Screening of flavonoids as candidate antibiotics against Enterococcus faecalis. J. Nat. Prod. 72, 719-724.
Jubair, N., Rajagopal, M., Chinnappan, S., Abdullah, N.B., Fatima, A., 2021. Review on the antibacterial mechanism of plant-derived compounds against multidrug-resistant bacteria (MDR). Evid. Based Complement. Alternat. Med. 2021, e3663315.
Kaludercic, N., Deshwal, S., Di Lisa, F., 2014. Reactive oxygen species and redox compartmentalization. Front. Physiol. 5, 285.
Karami, S., Yargholi, A., Sadati Lamardi, S.N., Soleymani, S., Shirbeigi, L., 2021. A review of ethnopharmacology, phytochemistry and pharmacology of Cymbopogon species. Res. J. Pharmacogn. 8, 83-112.
Kaszubska, W., Falls, H.D., Schaefer, V.G., Haasch, D., Frost, L., Hessler, P., Kroeger, P.E., White, D.W., Jirousek, M.R., Trevillyan, J.M., 2002. Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line. Mol. Cell. Endocrinol. 195, 109-118.
Khosravi Bakhtiari, M., Sharifiyazdi, H., Nazifi, S., Ghaemi, M., Hadadipour Zarandi, M., 2021. Effects of citral on serum antioxidant status and liver genes expressions of paraoxonase 1 and nitric oxide synthase in a rat model of streptozotocin-induced diabetes mellitus. Iran J. Vet. Res. 22, 195-202.
Kianasab, M.R., Mohammadhosseini, M., Nekoei, M., Mahdavi, B., Baheri, T., 2024. Screening of the compositions of essential oils and volatiles of Perovskia abrotanoides Karel. along with antioxidant, antibacterial and cytotoxic impacts of its methanol extract. Nat. Prod. Res. 38(21), 3813-3817.
Kouassi, E.K., Coulibaly, I., Rodica, P., Pintea, A., Ouattara, S., Odagiu, A., 2017. HPLC phenolic compounds analysis and antifungal activity of extracts from Cymbopogon citratus (DC) Stapf against Fusarium graminearum and Fusarium oxysporum sp tulipae. J. Sci. Res. Rep. 14(5), 1-11.
Lee, H.N., Shin, S.A., Choo, G.S., Kim, H.J., Park, Y.S., Kim, B.S., Kim, S.K., Cho, S.D., Nam, J.S., Choi, C.S., 2018. Anti-inflammatory effect of quercetin and galangin in LPS-stimulated RAW264.7 macrophages and DNCB-induced atopic dermatitis animal models. Int. J. Mol. Med. 41, 888-898.
Li, L., Luo, W., Qian, Y., Zhu, W., Qian, J., Li, J., Jin, Y., Xu, X., Liang, G., 2019. Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses. Phytomedicine 59, 152774.
Li, Y., Zhao, Y., Tan, X., Liu, J., Zhi, Y., Yi, L., Bai, S., Du, Q., Li, Q.X., Dong, Y., 2020. Isoorientin inhibits inflammation in macrophages and endotoxemia mice by regulating glycogen synthase kinase 3β. Mediators Inflamm. 2020, 8704146.
Liang, Y., Zhang, Y., Liu, M., Han, X., Zhang, J., Zhang, X., Chu, L., 2020. Protective effect of quercetin against myocardial ischemia as a Ca2+ channel inhibitor: Involvement of inhibiting contractility and Ca2+ influx via L-type Ca2+ channels. Arch. Pharm. Res. 43, 808-820.
Lin, Q., Chen, X.-Y., Zhang, J., Yuan, Y.-L., Zhao, W., Wei, B., 2018. Upregulation of SIRT1 contributes to the cardioprotective effect of rutin against myocardial ischemia-reperfusion injury in rats. J. Funct. Foods 46, 227-236.
Liu, Y., Song, Y., Li, S., Mo, L., 2021. Cardioprotective effect of quercetin against ischemia/reperfusion injury is mediated through NO system and mitochondrial K-ATP channels. Cell J. (Yakhteh) 23, 184.
Lobiuc, A., Pavăl, N.-E., Mangalagiu, I.I., Gheorghiță, R., Teliban, G.-C., Amăriucăi-Mantu, D., Stoleru, V., 2023. Future antimicrobials: Natural and functionalized phenolics. Molecules 28, 1114.
Lu, Q., Hao, M., Wu, W., Zhang, N., Isaac, A.T., Yin, J., Zhu, X., Du, L., Yin, X., 2018. Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway. Acta Biochim. Pol. 65, 35-41.
Luo, Y., Shang, P., Li, D., 2017. Luteolin: A flavonoid that has multiple cardio-protective effects and its molecular mechanisms. Front. Pharmacol. 8(OCT), 692.
Madi, Y.F., Choucry, M.A., El-Marasy, S.A., Meselhy, M.R., El-Kashoury, E.-S.A., 2020. UPLC-Orbitrap HRMS metabolic profiling of Cymbopogon citratus cultivated in Egypt; neuroprotective effect against AlCl3-induced neurotoxicity in rats. J. Ethnopharmacol. 259, 112930.
Magotra, S., Singh, Ajeet Pal, Singh, Amar Pal, 2021a. A review on pharmacological activities of Cymbopogon citratus. Int. J. Pharm. Drug Anal. 151-157.
Mahajan, U.B., Chandrayan, G., Patil, C.R., Arya, D.S., Suchal, K., Agrawal, Y.O., Ojha, S., Goyal, S.N., 2017. The protective effect of apigenin on myocardial injury in diabetic rats mediating activation of the PPAR-γ pathway. Int. J. Mol. Sci. 18, 756.
Malik, A., Jamil, U., Butt, T.T., Waquar, S., Gan, S.H., Shafique, H., Jafar, T.H., 2019. In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model. Drug Des. Dev. Ther. 13, 1501.
Mandić, L., Sadžak, A., Strasser, V., Baranović, G., Domazet Jurašin, D., Dutour Sikirić, M., Šegota, S., 2019. Enhanced protection of biological membranes during lipid peroxidation: Study of the interactions between flavonoid-loaded mesoporous silica nanoparticles and model cell membranes. Int. J. Mol. Sci. 20, 2709.
Manzoor, M.F., Ahmad, N., Ahmed, Z., Siddique, R., Zeng, X., Rahaman, A., Muhammad Aadil, R., Wahab, A., 2019. Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives. J. Food Biochem. 43(9), e12974.
Martins, W. da S., de Araújo, J.S.F., Feitosa, B.F., Oliveira, J.R., Kotzebue, L.R.V., Agostini, D.L. da S., de Oliveira, D.L.V., Mazzetto, S.E., Cavalcanti, M.T., da Silva, A.L., 2021. Lemongrass (Cymbopogon citratus DC. Stapf) essential oil microparticles: Development, characterization, and antioxidant potential. Food Chem. 355, 129644.
Méabed, E.M.H., Abou-Sreea, A.I.B., Roby, M.H.H., 2018. Chemical analysis and giardicidal effectiveness of the aqueous extract of Cymbopogon citratus Stapf. Parasitol. Res. 117, 1745-1755.
Mechchate, H., Es-safi, I., Haddad, H., Bekkari, H., Grafov, A., Bousta, D., 2021. Combination of catechin, epicatechin, and rutin: Optimization of a novel complete antidiabetic formulation using a mixture design approach. J. Nutr. Biochem. 88, 108520.
Messaoudi, M., Rebiai, A., Sawicka, B., Atanassova, M., Ouakouak, H., Larkem, I., Egbuna, C., Awuchi, C.G., Boubekeur, S., Ferhat, M.A., Begaa, S., Benchikha, N., 2022. Effect of extraction methods on polyphenols, flavonoids, mineral elements, and biological activities of essential oil and extracts of Mentha pulegium L. Molecules 27(1), 11.
Miri, M.R., Zare, A., Saberzadeh, J., Baghban, N., Nabipour, I., Tamadon, A., 2022. Anti-lung cancer marine compounds: A review. Ther. Innov. Regul. Sci. 56(2), 191-205.
Mirzaei, M., Ladan Moghadam, A., Hakimi, L., Danaee, E., 2020. Plant growth promoting rhizobacteria (PGPR) improve plant growth, antioxidant capacity, and essential oil properties of lemongrass (Cymbopogon citratus) under water stress. Iran. J. Plant Physiol. 10, 3155-3166.
Mirzaei, R., Ranjbar, R., 2022. Hijacking host components for bacterial biofilm formation: An advanced mechanism. Int. Immunopharmacol. 103, 108471.
Mohamed, M.S., Abdelkader, K., Gomaa, H.A.M., Batubara, A.S., Gamal, M., Sayed, A.M., 2022. Mechanistic study of the antibacterial potential of the prenylated flavonoid auriculasin against Escherichia coli. Arch. Pharm. 355, 2200360.
Mohammadhosseini, M., Frezza, C., Venditti, A., Akbarzadeh, A., 2019. Ethnobotany and phytochemistry of the genus Eremostachys Bunge. Curr. Org. Chem. 23, 1828-1842.
Mohammadhosseini, M., Frezza, C., Venditti, A., Sarker, S., 2021. A systematic review on phytochemistry, ethnobotany and biological activities of the genus Bunium L. Chem. Biodivers. 18(11), e2100317.
Nayki, C., Nayki, U., Keskin Cimen, F., Kulhan, M., Yapca, O.E., Kurt, N., Bilgin Ozbek, A., 2018. The effect of rutin on ovarian ischemia-reperfusion injury in a rat model. Gynecol. Endocrinol. 34, 809-814.
Ngogang, M.P., Ernest, T., Kariuki, J., Mouliom Mouiche, M.M., Ngogang, J., Wade, A., van der Sande, M.A.B., 2021. Microbial contamination of chicken litter manure and antimicrobial resistance threat in an urban area setting in Cameroon. Antibiotics 10(1), 20.
Nordeen, S.K., Bona, B.J., Jones, D.N., Lambert, J.R., Jackson, T.A., 2013. Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin. Horm. Cancer 4, 293-300.
Oboh, G., Adefegha, S.A., Ademosun, A.O., Unu, D., 2010. Effects of hot water treatment on the phenolic phytochemicals and antioxidant activities of lemongrass (Cymbopogon citratus). Electron. J. Environ. Agric. Food Chem. 9, 503-513.
Ohemeng, K.A., Schwender, C.F., Fu, K.P., Barrett, J.F., 1993. DNA gyrase inhibitory and antibacterial activity of some flavones. Bioorg. Med. Chem. Lett. 3, 225-230.
Oladeji, O.S., Adelowo, F.E., Ayodele, D.T., Odelade, K.A., 2019. Phytochemistry and pharmacological activities of Cymbopogon citratus: A review. Sci. Afr. 6, e00137.
Olorunnisola, S.K., Asiyanbi, H.T., Hammed, A.M., Simsek, S., 2014. Biological properties of lemongrass: An overview. Int. Food Res. J. 21, 455.
Olukunle, O.F., Adenola, O.J., 2019. Comparative antimicrobial activity of lemongrass (Cymbopogon citratus) and garlic (Allium sativum) extracts on Salmonella typhi. J. Adv. Med. Pharm. Sci. 1-9.
Orrego, R., Leiva, E., Cheel, J., 2009. Inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus (lemongrass) on human low density lipoprotein oxidation. Molecules 14, 3906-3913.
Oteiza, P.I., Erlejman, A.G., Verstraeten, S.V., Keen, C.L., Fraga, C.G., 2005. Flavonoid-membrane interactions: A protective role of flavonoids at the membrane surface? Clin. Dev. Immunol. 12, 19-25.
Ousaaid, D., Laaroussi, H., Bakour, M., El Ghouizi, A., El Menyiy, N., Lyoussi, B., El Arabi, I., 2022. Effect of a combination of Rosa canina fruits and apple cider vinegar against hydrogen peroxide-induced toxicity in experimental animal models. J. Food Qual. 2022, e7381378.
Owumi, S.E., Lewu, D.O., Arunsi, U.O., Oyelere, A.K., 2021. Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis. Hum. Exp. Toxicol. 40, 1656-1672.
Pan, D., Machado, L., Bica, C.G., Machado, A.K., Steffani, J.A., Cadoná, F.C., 2022. In vitro evaluation of antioxidant and anticancer activity of lemongrass (Cymbopogon citratus (D.C.) Stapf). Nutr. Cancer 74, 1474-1488.
Pan, D., Machado, L., Bica, C.G., Machado, A.K., Steffani, J.A., Cadoná, F.C., 2021. In vitro evaluation of antioxidant and anticancer activity of lemongrass (Cymbopogon citratus (D.C.) Stapf). Nutr. Cancer 74(4), 1474-1488.
Park, M.J., Lee, E.K., Heo, H.-S., Kim, M.-S., Sung, B., Kim, M.K., Lee, J., Kim, N.D., Anton, S., Choi, J.S., 2009. The anti-inflammatory effect of kaempferol in aged kidney tissues: The involvement of nuclear factor- kappaB via nuclear factor-inducing kinase/IκB kinase and mitogen-activated protein kinase pathways. J. Med. Food 12, 351-358.
Pearson, J.P., Feldman, M., Iglewski, B.H., Prince, A., 2000. Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect. Immun. 68, 4331-4334.
Poudel, B., Nepali, S., Xin, M., Ki, H.-H., Kim, Y.-H., Kim, D.-K., Lee, Y.-M., 2015. Flavonoids from Triticum aestivum inhibit adipogenesis in 3T3-L1 cells by upregulating the insig pathway. Mol. Med. Rep. 12(2), 3139-3145.
Qi, Y., Ying, Y., Zou, J., Fang, Q., Yuan, X., Cao, Y., Cai, Y., Fu, S., 2020. Kaempferol attenuates cisplatin-induced cardiac injury via inhibiting STING/NF-κB-mediated inflammation. Am. J. Transl. Res. 12, 8007.
Qian, W., Liu, M., Fu, Y., Zhang, J., Liu, W., Li, J., Li, X., Li, Y., Wang, T., 2020. Antimicrobial mechanism of luteolin against Staphylococcus aureus and Listeria monocytogenes and its antibiofilm properties. Microbiol. Pathog. 142, 104056.
Rabbani, S., Devi, K., Khanam, S., Zahra, N., 2006. Citral, a component of lemongrass oil inhibits the clastogenic effect of nickel chloride in mouse micronucleus test system. Pak. J. Pharm. Sci. 19, 108-113.
Rogerio, A.P., Dora, C.L., Andrade, E.L., Chaves, J.S., Silva, L.F., Lemos-Senna, E., Calixto, J.B., 2010. Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacol. Res. 61, 288-297.
Roy, P.K., Park, S.-H., Song, M.G., Park, S.Y., 2022. Antimicrobial efficacy of quercetin against Vibrio parahaemolyticus biofilm on food surfaces and downregulation of virulence genes. Polymers 14, 3847.
Sahal, G., Woerdenbag, H.J., Hinrichs, W.L.J., Visser, A., Tepper, P.G., Quax, W.J., van der Mei, H.C., Bilkay, I.S., 2020. Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm formation by Candida tropicalis isolates; An in vitro study. J. Ethnopharmacol. 246, 112188.
Saini, R., Sharma, N., Oladeji, O.S., Sourirajan, A., Dev, K., Zengin, G., El-Shazly, M., Kumar, V., 2022. Traditional uses, bioactive composition, pharmacology, and toxicology of Phyllanthus emblica fruits: A comprehensive review. J. Ethnopharmacol. 282, 114570.
Salaria, D., Rolta, R., Sharma, N., Patel, C.N., Ghosh, A., Dev, K., Sourirajan, A., Kumar, V., 2021. In vitro and in silico antioxidant and anti-inflammatory potential of essential oil of Cymbopogon citratus (DC.) Stapf. of North-Western Himalaya. J. Biomol. Struct. Dyn. 1-15.
Salatin, S., Bazmani, A., Shahi, S., Naghili, B., Memar, M.Y., Dizaj, S.M., 2022. Antimicrobial benefits of flavonoids and their nanoformulations. Curr. Pharm. Des. 28, 1419-1432.
Salvado, L., Palomer, X., Barroso, E., Vázquez-Carrera, M., 2015. Targeting endoplasmic reticulum stress in insulin resistance. Trends Endocrinol. Metab. 26, 438-448.
Seukep, A.J., Nembu, N.E., Mbuntcha, H.G., Kuete, V., 2023. Chapter Two-Bacterial Drug Resistance Towards Natural Products, in: Kuete, V. (Ed.), Advances in Botanical Research, African Flora to Fight Bacterial Resistance, Part I: Standards for the Activity of Plant-Derived Products. Academic Press, pp. 21-45.
Sezik, E., Aslan, M., Yesilada, E., Ito, S., 2005. Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques. Life Sci. 76, 1223-1238.
Shah, G., Shri, R., Panchal, V., Sharma, N., Singh, B., Mann, A.S., 2011. Scientific basis for the therapeutic use of Cymbopogon citratus, Stapf (Lemongrass). J. Adv. Pharm. Technol. Res. 2, 3.
Shao, L., Shao, Y., Yuan, Y., 2021. Pinocembrin flavanone inhibits cell viability in PC-3 human prostate cancer by inducing cellular apoptosis, ROS production, and cell cycle arrest. Acta Pharm. 71, 669-678.
Sharifi-Rad, J., Quispe, C., Imran, M., Rauf, A., Nadeem, M., Gondal, T.A., Ahmad, B., Atif, M., Mubarak, M.S., Sytar, O., Zhilina, O.M., Garsiya, E.R., Smeriglio, A., Trombetta, D., Pons, D.G., Martorell, M., Cardoso, S.M., Razis, A.F.A., Sunusi, U., Kamal, R.M., Rotariu, L.S., Butnariu, M., Docea, A.O., Calina, D., 2021. Genistein: An integrative overview of its mode of action, pharmacological properties, and health benefits. Oxid. Med. Cell. Longev. 2021, e3268136.
Sharma, D., Tekade, R.K., Kalia, K., 2020. Kaempferol in ameliorating diabetes-induced fibrosis and renal damage: An in vitro and in vivo study in diabetic nephropathy mice model. Phytomedicine 76, 153235.
Sheth, P.A., Pawar, A.T., Mote, C.S., More, C., 2021. Antianemic activity of polyherbal formulation, Raktavardhak Kadha, against phenylhydrazine-induced anemia in rats. J. Ayurveda Integr. Med. 12(2), 340-345.
Silva, F.C., Bramatti, I.C., Toledo, A.G., Salles, F.M., Itinose, A.M., Marek, C.B., 2017. Antihyperglycemic effect of quercetin in ovariectomized rats treated with tamoxifen. J. Med. Food 20, 235-242.
Simões, D.M., Malheiros, J., Antunes, P.E., Figueirinha, A., Cotrim, M.D., Fonseca, D.A., 2020. Vascular activity of infusion and fractions of Cymbopogon citratus (DC) Stapf. in human arteries. J. Ethnopharmacol. 258, 112947.
Soliman, W.S., Salaheldin, S., Amer, H.M., 2017. Chemical composition evaluation of Egyptian lemongrass, Cymbopogon citratus, essential oil. Int. J. Sci. Eng. Res, 8(11), 630-634.
Son, M., Oh, S., Choi, J., Jang, J.T., Choi, C.H., Park, K.Y., Son, K.H., Byun, K., 2019. Attenuation of inflammation and leptin resistance by pyrogallol-phloroglucinol-6,6-bieckol in the brain of obese animal models. Nutrients 11, 2773.
Son, M., Oh, S., Jang, J.T., Son, K.H., Byun, K., 2021. Pyrogallol-phloroglucinol-6,6-bieckol attenuates high-fat diet-induced hypertension by modulating endothelial-to-mesenchymal transition in the aorta of mice. Oxid. Med. Cell. Longev. 2021, 8869085.
Soromou, L.W., Zhang, Y., Cui, Y., Wei, M., Chen, N., Yang, X., Huo, M., Baldé, A., Guan, S., Deng, X., Wang, D., 2013. Subinhibitory concentrations of pinocembrin exert anti-Staphylococcus aureus activity by reducing α-toxin expression. J. Appl. Microbiol. 115, 41-49.
Sousa, R., Figueirinha, A., Batista, M.T., Pina, M.E., 2021. Formulation effects in the antioxidant activity of extract from the leaves of Cymbopogon citratus (DC) Stapf. Molecules 26, 4518.
Strawa, J.W., Jakimiuk, K., Pawlikowska-Pawlęga, B., Gruszecki, W.I., Kapral-Piotrowska, J., Wiater, A., Tomczyk, M., 2023. Polar localization of new flavonoids from aerial parts of Scleranthus perennis and Hottonia palustris and their modulatory action on lipid membranes properties. Biochim. Biophys. Acta Biomembr. 1865, 184142.
Subramaniam, G., Yew, X.Y., Sivasamugham, L.A., 2020. Antibacterial activity of Cymbopogon citratus against clinically important bacteria. South Afr. J. Chem. Eng. 34, 26-30.
Sugita-Konishi, Y., Hara-Kudo, Y., Amano, F., Okubo, T., Aoi, N., Iwaki, M., Kumagai, S., 1999. Epigallocatechin gallate and gallocatechin gallate in green tea catechins inhibit extracellular release of Vero toxin from enterohemorrhagic Escherichia coli O157:H7. Biochim. Biophys. Acta Gen. Subjects 1472, 42-50.
Sun, X., Sun, G., Wang, M., Xiao, J., Sun, X.-B., 2011. Protective effects of cynaroside against H2O2-induced apoptosis in H9c2 cardiomyoblasts. J. Cell. Biochem. 112, 2019-2029.
Suriyanarayanan, B., Shanmugam, K., Santhosh, R.S., 2013. Synthetic quercetin inhibits mycobacterial growth possibly by interacting with DNA gyrase. Rom. Biotechnol. Lett. 18, 8587-8593.
Szekalska, M., Sosnowska, K., Tomczykowa, M., Winnicka, K., Kasacka, I., Tomczyk, M., 2020. In vivo anti-inflammatory and anti-allergic activities of cynaroside evaluated by using hydrogel formulations. Biomed. Pharm. Ther. 121, 109681.
Tang, F., Li, L., Meng, X.-M., Li, B., Wang, C.-Q., Wang, S.-Q., Wang, T.-L., Tian, Y.-M., 2019. Inhibition of alpha-hemolysin expression by resveratrol attenuates Staphylococcus aureus virulence. Microb. Pathog. 127, 85-90.
Tauffenberger, A., Magistretti, P.J., 2021. Reactive oxygen species: Beyond their reactive behavior. Neurochem. Res. 1-11.
Tavares, F., Costa, G., Francisco, V., Liberal, J., Figueirinha, A., Lopes, M.C., Cruz, M.T., Batista, M.T., 2015. Cymbopogon citratus industrial waste as a potential source of bioactive compounds: Bioactive compounds from Cymbopogon citratus industrial waste. J. Sci. Food Agric. 95, 2652-2659.
Thagriki, D.S., 2022. Quercetin and its derivatives are potent inhibitors of the dengue virus. Trends Phytochem. Res. 6(1), 70-85.
Thangaiyan, R., Robert, B.M., Arjunan, S., Govindasamy, K., Nagarajan, R.P., 2018. Preventive effect of apigenin against isoproterenol-induced apoptosis in cardiomyoblasts. J. Biochem. Mol. Toxicol. 32, e22213.
Topal, İ., Bilgin, A.Ö., Çimen, F.K., Kurt, N., Süleyman, Z., Bilgin, Y., Özçiçek, A., Altuner, D., 2018. The effect of rutin on cisplatin-induced oxidative cardiac damage in rats. Anatol. J. Cardiol. 20, 136.
Touil, Y.S., Seguin, J., Scherman, D., Chabot, G.G., 2011. Improved antiangiogenic and antitumor activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice. Cancer Chemother. Pharmacol. 68, 445-455.
Van, L.V., Pham, E.C., Nguyen, C.V., Duong, N.T.N., Le Thi, T.V., Truong, T.N., 2022. In vitro and In vivo antidiabetic activity, isolation of flavonoids, and in silico molecular docking of stem extract of Merremia tridentata (L.). Biomed. Pharm. Ther. 146, 112611.
Vaou, N., Stavropoulou, E., Voidarou, C. (Chrysa), Tsakris, Z., Rozos, G., Tsigalou, C., Bezirtzoglou, E., 2022. Interactions between medical plant-derived bioactive compounds: Focus on antimicrobial combination effects. Antibiotics 11, 1014.
Veiko, A.G., Olchowik-Grabarek, E., Sekowski, S., Roszkowska, A., Lapshina, E.A., Dobrzynska, I., Zamaraeva, M., Zavodnik, I.B., 2023. Antimicrobial activity of quercetin, naringenin and catechin: Flavonoids inhibit Staphylococcus aureus-induced hemolysis and modify membranes of bacteria and erythrocytes. Molecules 28, 1252.
Veiko, A.G., Sekowski, S., Lapshina, E.A., Wilczewska, A.Z., Markiewicz, K.H., Zamaraeva, M., Zhao, H., Zavodnik, I.B., 2020. Flavonoids modulate liposomal membrane structure, regulate mitochondrial membrane permeability and prevent erythrocyte oxidative damage. Biochim. Biophys. Acta Biomembr. 1862, 183442.
Vishwakarma, A., Singh, T.U., Rungsung, S., Kumar, T., Kandasamy, A., Parida, S., Lingaraju, M.C., Kumar, A., Kumar, A., Kumar, D., 2018. Effect of kaempferol pretreatment on myocardial injury in rats. Cardiovasc. Toxicol. 18, 312-328.
Wang, B., Liu, D., Zhu, Q., Li, M., Chen, H., Guo, Y., Fan, L., Yue, L., Li, L., Zhao, M., 2016. Rutin ameliorates kidney interstitial fibrosis in rats with obstructive nephropathy. Int. Immunopharmacol. 35, 77-84.
Wang, J., Liu, Y.-T., Xiao, L., Zhu, L., Wang, Q., Yan, T., 2014. Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway. Inflammation 37, 2085-2090.
Wrońska, N., Szlaur, M., Zawadzka, K., Lisowska, K., 2022. The synergistic effect of triterpenoids and flavonoids—new approaches for treating bacterial infections? Molecules 27, 847.
Wu, B., Song, H., Fan, M., You, F., Zhang, L., Luo, J., Li, J., Wang, L., Li, C., Yuan, M., 2020. Luteolin attenuates sepsis-induced myocardial injury by enhancing autophagy in mice. Int. J. Mol. Med. 45, 1477-1487.
Wu, Q., Li, W., Zhao, J., Sun, W., Yang, Q., Chen, C., Xia, P., Zhu, J., Zhou, Y., Huang, G., 2021. Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation. Biomed. Pharm. Ther. 137, 111308.
Xianchu, L., Lan, Z., Ming, L., Yanzhi, M., 2018. Protective effects of rutin on lipopolysaccharide-induced heart injury in mice. J. Toxicol. Sci. 43, 329-337.
Xiao, C., Xia, M.-L., Wang, J., Zhou, X.-R., Lou, Y.-Y., Tang, L.-H., Zhang, F.-J., Yang, J.-T., Qian, L.-B., 2019. Luteolin attenuates cardiac ischemia/reperfusion injury in diabetic rats by modulating Nrf2 antioxidative function. Oxid. Med. Cell. Longev. 20199, 2719252.
Yuan, L., Han, X., Li, W., Ren, D., Yang, X., 2016. Isoorientin prevents hyperlipidemia and liver injury by regulating lipid metabolism, antioxidant capability, and inflammatory cytokine release in high-fructose-fed mice. J. Agric. Food Chem. 64, 2682-2689.
Zaman, F.Q., Jaffel, K., Abdelmageed, A.H.A., 2022. The effects of post-harvest drying period on the yield and chemical composition of leaf essential oil from Cymbopogon citratus (DC.) Stapf. J. Essent. Oil Bear. Plants 25, 571-580.
Zamboni, F., Wong, C.K., Collins, M.N., 2023. Hyaluronic acid association with bacterial, fungal and viral infections: Can hyaluronic acid be used as an antimicrobial polymer for biomedical and pharmaceutical applications? Bioact. Mater. 19, 458-473.
Zhai, K., Mazurakova, A., Koklesova, L., Kubatka, P., Büsselberg, D., 2021. Flavonoids synergistically enhance the anti-glioblastoma effects of chemotherapeutic drugs. Biomolecules 11, 1841.
Zhang, L., Kong, Y., Wu, D., Zhang, H., Wu, J., Chen, J., Ding, J., Hu, L., Jiang, H., Shen, X., 2008. Three flavonoids targeting the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: Crystal structure characterization with enzymatic inhibition assay. Protein Sci. 17, 1971-1978.
Zhang, L., Zhu, X.-Z., Badamjav, R., Zhang, J.-Z., Kou, J.-P., Yu, B.-Y., Li, F., 2022. Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways. Eur. J. Pharmacol. 174748.
Zhou, D.-C., Zheng, G., Jia, L.-Y., He, X., Zhang, C.-F., Wang, C.-Z., Yuan, C.-S., 2021. Comprehensive evaluation on anti-inflammatory and anti-angiogenic activities in vitro of fourteen flavonoids from Daphne Genkwa based on the combination of efficacy coefficient method and principal component analysis. J. Ethnopharmacol. 268, 113683.
Zhou, P., Tang, D., Zou, J., Wang, X., 2022. An alternative strategy for enhancing stability and antimicrobial activity of catechins by natural deep eutectic solvents. LWT 153, 112558.
Zhumakanova, B.S., Korona-Głowniak, I., Skalicka-Woźniak, K., Ludwiczuk, A., Baj, T., Wojtanowski, K.K., Józefczyk, A., Zhaparkulova, K.A., Sakipova, Z.B., Malm, A., 2021. Phytochemical fingerprinting and in vitro antimicrobial and antioxidant activity of the aerial parts of Thymus marschallianus Willd. and Thymus seravschanicus Klokov growing widely in southern Kazakhstan. Molecules 26, 3193.
Ziqubu, K., Muller, C.J.F., Dludla, P.V., Mthembu, S.X.H., Obonye, N., Louw, J., Kappo, A.P., Silvestri, S., Orlando, P., Tiano, L., Mazibuko-Mbeje, S.E., 2020. Impact of isoorientin on metabolic activity and lipid accumulation in differentiated adipocytes. Molecules 25, 1773.
Ziyan, L., Yongmei, Z., Nan, Z., Ning, T., Baolin, L., 2007. Evaluation of the anti-inflammatory activity of luteolin in experimental animal models. Planta Med. 73, 221-226.
