The effect of physical fitness level on mir-155 gene expression mediated by job stress in Shiraz firefighters
الموضوعات : Journal of Physical Activity and Hormones
Kamran Rajabi
1
,
Homa Sheikhani Shahin
2
1 - Department of exercise physiology, Zand Higher Education Institute, shiraz, Iran
2 - Assistant professor in exercise physiology, Department of exercise physiology, Zand Higher Education Institute, shiraz, Iran
الکلمات المفتاحية: Physical fitness, Job stress, mir-155, Firefighters,
ملخص المقالة :
Introduction: Firefighters are increasingly exposed to factors that affect their physical and mental health. The aim of present study was examined the effect of physical fitness level on mir-155 gene expression mediated by job stress in Shiraz firefighters.
Material & Methods: Twenty firefighters volunteered to participate in this study. To measure the physical fitness of the subjects, the Physical Fitness Index Questionnaire (Sharkey, 1990) was used, and to assess the level of job stress, the Job Stress Questionnaire (Elliott, 1994) was used. The expression of the mir-155 gene was also measured by Real-time PCR. Smart PLS software was used to analyze the data, with a significance level of p<0.05.
Results: The results showed that the level of physical fitness and job stress did not have a direct and significant effect on the expression of the mir-155 gene in Shiraz firefighters, and the level of physical fitness also did not have a direct and significant effect on their job stress.
Conclusion: These results indicate that to improve the health and performance of firefighters, attention should be paid to other factors that may have a greater impact on gene expression and job stress.
1. Jeung DY, Hyun DS, Kim I, Chang SJ. Effects of emergency duties on cardiovascular diseases in firefighters: a 13-year retrospective cohort study. J Occup Environ Med. 2022;64(6):510-4. doi: 10.1097/JOM.0000000000002511
2. Hyun DS, Jeung DY, Kim C, Ryu HY, Chang SJ. Does emotional labor increase the risk of suicidal ideation among firefighters? Yonsei Med J. 2020;61(2):179-85. doi: 10.3349/ymj.2020.61.2.179
3. Martin ZT, Schlaff RA, Hemenway JK, Coulter JR, Knous JL, Lowry JE, et al. Cardiovascular disease risk factors and physical fitness in volunteer firefighters. Int J Exerc Sci. 2019;12(2):764-76.
4. Smith DL, Graham E, Stewart D, Mathias KC. Cardiovascular disease risk factor changes over 5 years among male and female US firefighters. J Occup Environ Med. 2020;62(6):398-402. doi: 10.1097/JOM.0000000000001855
5. Vicente MM, Herrero DC, Prieto JP. Cardiorespiratory fitness in Spanish firefighters: age differences and associations between fitness-related parameters. J Occup Environ Med. 2021;63(5):e318-22. doi: 10.1097/JOM.0000000000002189
6. Ras J, Soteriades ES, Smith DL, Kengne AP, Leach L. Evaluation of the relationship between occupational-specific task performance and measures of physical fitness, cardiovascular and musculoskeletal health in firefighters. BMC Public Health. 2024;24(1):20. doi: 10.1186/s12889-023-17478-5
7. Zhou SS, Jin JP, Wang JQ, Zhang ZG, Freedman JH, Zheng Y, et al. miRNAs in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges. Acta Pharmacol Sin. 2018;39(7):1073-84. doi: 10.1038/aps.2018.30
8. Samra M, Srivastava K. Non-coding RNA and their potential role in cardiovascular diseases. Gene. 2023;851:147011. doi: 10.1016/j.gene.2022.147011
9. Catalanotto C, Cogoni C, Zardo G. MicroRNA in control of gene expression: an overview of nuclear functions. Int J Mol Sci. 2016;17(10):1712. doi: 10.3390/ijms17101712
10. Zhang B, Li B, Qin F, Bai F, Sun C, Liu Q. Expression of serum microRNA-155 and its clinical importance in patients with heart failure after myocardial infarction. J Int Med Res. 2019;47(12):6294-302. doi: 10.1177/0300060519887266
11. Seok HY, Chen J, Kataoka M, Huang ZP, Ding J, Yan J, et al. Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy. Circ Res. 2014;114(10):1585-95. doi: 10.1161/CIRCRESAHA.114.303041
12. Sharkey BJ. Physiology of fitness. Champaign (IL): Human Kinetics; 1990. p. 207-31.
13. Moghadasi M, Nikbakht M, Kuchaki M. Association between lifestyle status and dyslipidemia in Ilam adults. Iran J Endocrinol Metab. 2011;13(2):137-44.
14. Jahanbakhsh Ganjeh S, Oreyzi H. The relationship of job demands, job control with job stress, positive affect and negative affect among employees. Res Cogn Behav Sci. 2012;2(1):75-90.
15. Mooren FC, Viereck J, Krüger K, Thum T. Circulating microRNAs as potential biomarkers of aerobic exercise capacity. Am J Physiol Heart Circ Physiol. 2014;306(4):H557-63. doi: 10.1152/ajpheart.00711.2013
16. Chizewski A, Box A, Kesler R, Petruzzello SJ. Fitness fights fires: exploring the relationship between physical fitness and firefighter ability. Int J Environ Res Public Health. 2021;18(22):11733. doi: 10.3390/ijerph182211733
17. Sluiter JK, Frings-Dresen MH. What do we know about ageing at work? Evidence-based fitness for duty and health in fire fighters. Ergonomics. 2007;50(11):1897-913. doi: 10.1080/00140130701676005
18. Meza CA, Amador M, McAinch AJ, Begum K, Roy S, Bajpeyi S. Eight weeks of combined exercise training do not alter circulating microRNAs-29a, -133a, -133b, and -155 in young, healthy men. Eur J Appl Physiol. 2022;122(4):921-33. doi: 10.1007/s00421-022-04893-9
19. Li D, Wang P, Wei W, Wang C, Zhong Y, Lv L, et al. Serum microRNA expression patterns in subjects after the 5-km exercise are strongly associated with cardiovascular adaptation. Front Physiol. 2021;12:755656. doi: 10.3389/fphys.2021.755656
20. Ras J, Smith DL, Soteriades ES, Kengne AP, Leach L. Association between physical fitness and cardiovascular health in firefighters. Int J Environ Res Public Health. 2023;20(11):5930. doi: 10.3390/ijerph20115930
21. Soteriades ES, Vogazianos P, Tozzi F, Antoniades A, Economidou EC, Psalta L, et al. Exercise and occupational stress among firefighters. Int J Environ Res Public Health. 2022;19(9):4986. doi: 10.3390/ijerph19094986
