Anti-depressant effect of Oliveria Decumbens in gonadectomized rat
Siyavash Moshafi
1
(
Faculty of Veterinary Medicine, SR.C., Islamic Azad University, Tehran, Iran
)
Shahin Hassanpour
2
(
Department of Veterinary Basic Sciences, SR.C., Islamic Azad University, Tehran, Iran
)
Ahmad Asghari
3
(
Department of Veterinary Clinical Sciences, SR.C., Islamic Azad University, Tehran, Iran
)
Parviz Tajik
4
(
Department of Veterinary Clinical Sciences, SR.C., Islamic Azad University, Tehran, Iran
)
الکلمات المفتاحية: Antidepressant, Oliveria decumbens, Gonadectomy, Rat,
ملخص المقالة :
This study aimed to determine the antidepressant effect of Oliveria Decumbens extract (ODE) in gonadectomized rats. Thirty male rats were allocated into 6 experimental groups. The control group underwent identical surgeries, but the testes were not clamped, ligated, or excised. In the imipramine group, castration was identical, followed by imipramine administration (5 mg/kg) for 2 weeks. In groups 4, 5, and 6, following castration, rats were p.o. injected with ODE (100, 200, and 400 mg/kg) for 2 weeks, respectively. Then, the forced swimming test (FST), the tail suspension test (TST), and the open field test (OFT) were done. Also, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and total antioxidant status (TAS) were determined. According to the data, immobility time using FST and TST significantly increased in the gonadectomized rat (p< 0.05). Administration of imipramine significantly decreased immobility time using FST and TST (p< 0.05). A dose-dependent decrease in immobility time in the FST and TST was observed in gonadectomized rats treated with ODE (200 and 400 mg/kg) compared with the control group (P<0.05). Castration significantly decreased the number of crosses in OFT, and administration of imipramine or treatment with ODE (200 and 400 mg/kg) significantly increased it (p< 0.05). Serum MDA levels significantly increased, while SOD, GPx, and TAS levels decreased in gonadectomized rats compared with the control group (p< 0.05). Administration of the ODE (200 and 400 mg/kg) significantly decreased serum MDA while increasing SOD, GPx, and TAS levels (p< 0.05). These results suggest that ODE has an antidepressant effect in gonadectomized rats, mediated by its antioxidant activity.
[1] Ter Meulen WG, Draisma S, van Hemert AM, Schoevers RA, Kupka RW, Beekman AT, Penninx BW. Depressive and anxiety disorders in concert–A synthesis of findings on comorbidity in the NESDA study. Journal of Affective Disorders. 2021; 284: 85-97.
doi:10.1016/j.jad.2021.02.004
[2] Hantsoo L, Jagodnik KM, Novick AM, Baweja R, di Scalea TL, Ozerdem A, et al. The role of the hypothalamic-pituitary-adrenal axis in depression across the female reproductive lifecycle: current knowledge and future directions. Frontiers in Endocrinology. 2023; 14: 1295261.
doi:10.3389/fendo.2023.1295261
[3] Kundakovic M, Rocks D. Sex hormone fluctuation and increased female risk for depression and anxiety disorders: from clinical evidence to molecular mechanisms. Frontiers in Neuroendocrinology. 2022; 66: 101010. doi:10.1016/j.yfrne.2022
[4] Scahill LD. Imipramine. In: Encyclopedia of Autism Spectrum Disorders. 2021 (p: 2403). Cham: Springer International Publishing.
[5] Lievanos-Ruiz FJ, Fenton-Navarro B. Enzymatic biomarkers of oxidative stress in patients with depressive disorders. A systematic review. Clinical Biochemistry. 2024; 3:110788.
doi:10.1016/j.clinbiochem.2024.110788
[6] Zengil S, Laloğlu E. The effect of major depressive disorder comorbidity on ischemia-modified albumin levels, a marker of oxidative stress, and antioxidant defense system in patients with obsessive compulsive disorder. Frontiers in Psychiatry. 2024; 15: 1469640. doi:10.3389/fpsyt.2024.1469640
[7] Hauger RL, Saelzler UG, Pagadala MS, Panizzon MS. The role of testosterone, the androgen receptor, and hypothalamic-pituitary–gonadal axis in depression in ageing Men. Reviews in Endocrine and Metabolic Disorders. 2022; 23(6): 1259-73. doi:10.1007/s11154-022-09767-0
[8] de Wit AE, Giltay EJ, de Boer MK, Nolen WA, Bosker FJ, Penninx BW, Schoevers RA. Plasma androgens and the presence and course of depression in a large cohort of men. Psychoneuroendocrinology. 2021; 130: 105278.
doi:10.1016/j.psyneuen.2021.105278
[9] Alwhaibi A, Alsanea S, Almadi B, Al-Sabhan J, Alosaimi FD. Androgen deprivation therapy and depression in the prostate cancer patients: review of risk and pharmacological management. Aging Male. 2022; 25(1): 101-24. doi:10.1080/13685538.2022.2053954
[10] Mirahmad A, Ghoran SH, Alipour P, Taktaz F, Hassan S, Naderian M, et al. Oliveria decumbens Vent. (Apiaceae): Biological screening and chemical compositions. Journal of Ethnopharmacology. 2024; 318:117053. doi:10.1016/j.jep.2023.117053
[11] Mousavi SS, Karami A, Haghighi TM, Taban A, Nahar L, Sarker SD. Phytochemistry of Oliveria decumbens Vent. (Apiaceae) and its therapeutic potential: A systematic review. Fitoterapia. 2023; 105647. doi:10.1016/j.fitote.2023.105647
[12] Boveiri Dehsheikh A, Mahmoodi Sourestani M, Enayatizamir N, Safdarian M, Mottaghipisheh J. Oliveria decumbens, a Long‐Neglected Plant with Promising Phytochemical and Biological Properties. Chemistry & Biodiversity. 2024; 21(7): e202400810.
doi:10.1002/cbdv.202400810
[13] Mollaei S, Mamizadeh Z, Hazrati S, Hashempour H. The effect of ultrasonic pre-treatment on the yield, chemical composition and biological activity of essential oil in Oliveria decumbens flowers. Journal of Applied Research on Medicinal and Aromatic Plants. 2021; 24: 100313. doi:10.1016/j.jarmap.2021.100313
[14] Huh JS, Chung BH, Hong CH, Ryu JK, Kim JH, Han WK, et al. The effects of testosterone replacement on penile structure and erectile function after long-term castration in adult male rats. International Journal of Impotence Research. 2018; 30(3): 122-8.
doi:10.1038/s41443-017-0010-6
[15] Boivin JR, Piekarski DJ, Wahlberg JK, Wilbrecht L. Age, sex, and gonadal hormones differently influence anxiety-and depression-related behavior during puberty in mice. Psychoneuroendocrinology. 2017; 85: 78-87. doi:10.1016/j.psyneuen.2017.08.009
[16] Ochieng Nyalo P, Isanda Omwenga G, Piero Ngugi M. GC‐MS Analysis, Antibacterial and Antioxidant Potential of Ethyl Acetate Leaf Extract of Senna singueana (Delile) Grown in Kenya. Evidence‐Based Complementary and Alternative Medicine. 2022; 2022(1): 5436476.
doi:10.1155/2022/5436476
[17] Aubais Aljelehawy QH, Hadi Alshaibah LH, Abbas Al-Khafaji ZK. Evaluation of virulence factors among Staphylococcus aureus strains isolated from patients with urinary tract infection in Al-Najaf Al-Ashraf teaching hospital. Cellular, Molecular and Biomedical Reports. 2021; 1(2): 78-87. doi:10.55705/cmbr.2021.144995.1017
[18] Boissy A. Fear and fearfulness in animals. The Quarterly Review of Biology. 1995; 70(2): 165-91.
[19] Ueno H, Takahashi Y, Murakami S, Wani K, Matsumoto Y, Okamoto M, et al. Effect of simultaneous testing of two mice in the tail suspension test and forced swim test. Scientific Reports. 2022; 12(1):1-14.
doi:10.1038/s41598-022-12986-9
[20] Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neuroscience & Biobehavioral Reviews. 2005; 29(4-5): 571-625.
doi:10.1016/j.neubiorev.2005.03.009
[21] Takeda H, Tsuji M, Matsumiya T. Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. European journal of pharmacology. 1998; 350(1): 21-9.
doi:10.1016/s0014-2999(98)00223-4
[22] Erjavec GN, Sagud M, Perkovic MN, Strac DS, Konjevod M, Tudor L, et al. Depression: Biological markers and treatment. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2021; 8; 105: 110139. doi:10.1016/j.pnpbp.2020.110139
[23] Remes O, Mendes JF, Templeton P. Biological, psychological, and social determinants of depression: a review of recent literature. Brain sciences. 2021; 10; 11(12): 1633.
doi:10.3390/brainsci11121633
[24] Pu J, Liu Y, Zhang H, Tian L, Gui S, Yu Y, et al. An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder. Molecular Psychiatry. 2021; 26(8): 4265-76. doi:10.1038/s41380-020-0645-4
[25] Jung HJ, Shin HS. Effect of testosterone replacement therapy on cognitive performance and depression in men with testosterone deficiency syndrome. The world journal of men's health. 2016; 34(3): 194-9.
doi:10.5534/wjmh.2016.34.3.194
[26] Young AH, Juruena MF, De Zwaef R, Demyttenaere K. Vagus nerve stimulation as adjunctive therapy in patients with difficult-to-treat depression (RESTORE-LIFE): study protocol design and rationale of a real-world post-market study. BMC Psychiatry. 2020; 20: 1-2. doi:10.1186/s12888-020-02869-6
[27] Bangasser DA, Cuarenta A. Sex differences in anxiety and depression: circuits and mechanisms. Nature Reviews Neuroscience. 2021; 22(11): 674-84.
doi:10.1038/s41583-021-00513-0
[28] Barbosa ML, de Meneses AA, de Aguiar RP, e Sousa JM, Cavalcante AA, Maluf SW. Oxidative stress, antioxidant defense and depressive disorders: a systematic review of biochemical and molecular markers. Neurology, Psychiatry and Brain Research. 2020; 1; 36: 65-72. doi:10.1016/j.npbr.2020.02.006
[29] Liu Z, Cai Y, Zhang X, Zhu Z, He J. High serum levels of malondialdehyde and antioxidant enzymes are associated with post-stroke anxiety. Neurological Sciences. 2018; 39: 999-1007.
doi:10.1007/s10072-018-3287-4
[30] Jiménez‐Fernández S, Gurpegui M, Garrote‐Rojas D, Gutiérrez‐Rojas L, Carretero MD, Correll CU. Oxidative stress parameters and antioxidants in patients with bipolar disorder: Results from a meta‐analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls. Bipolar disorders. 2021; 23(2): 117-29.
doi:10.1111/bdi.12980
[31] Salehi V, Malekiasl H, Azizi M, Nouripour-Sisakht S, Gharaghani M, Saberinejad AA, et al. Oliveria decumbens extract exhibits hepatoprotective effects against bile duct ligation-induced liver injury in rats by reducing oxidative stress. Hepatitis Monthly. 2023; 31; 23(1).
doi:10.5812/hepatmon-131160
[32] Nassef NA, Abu-Shadi E, El Agaty S, Abdel Hamid G. Quercetin mitigates liver injury in a rat model of liver cholestasis. Bulletin of Egyptian Society for Physiological Sciences. 2020; 1; 40(1): 84-95. doi:10.21608/besps.2019.14512.1026
[33] Ait Tayeb AE, Poinsignon V, Chappell K, Bouligand J, Becquemont L, Verstuyft C. Major depressive disorder and oxidative stress: a review of peripheral and genetic biomarkers according to clinical characteristics and disease stages. Antioxidants. 2023; 17;12(4): 942.
doi:10.3390/antiox12040942
