درک مسیرهای مختلف مرگ برنامه ریزی شده سلولی در درمان هدفمند بیماری ها
الموضوعات :
امیر آراسته
1
,
مرتضی کریم پور
2
,
فائزه فلاح
3
,
سارا کیانی
4
1 - گروه زیست شناسی، واحد رشت، دانشگاه آزاد اسلامی، رشت، ایران
2 - گروه زیست شناسی، دانشگاه آزاد اسلامی واحد رشت
3 - گروه زیست شناسی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران
4 - گروه زیست شناسی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران
الکلمات المفتاحية: کلمات کلیدی: آپوپتوز, مسیرهای پیام رسانی, کاسپاز, سرطان,
ملخص المقالة :
چکیده ایجاد درمان¬هایی که مرگ کارآمد سلول¬های سرطانی توسط آپوپتوز را تشویق می¬کند، سنگ بنا و هدف انکولوژی بالینی برای بیش از سی سال بوده است. مسیرهای پیام رسانی متعددی که به¬عنوان درونی و بیرونی شناخته می¬شوند، در فرآیند مرگ برنامه ریزی شده سلولی نقش دارند. این مسیرها توسط محرک-های مختلفی مانند نظارت بر سیستم ایمنی، آسیب DNA و استرس سلولی فعال می¬شوند. مرگ سلولی همچنین ممکن است تحت تأثیر نحوه تعامل مسیرهای آپوپتوز با سایر فرآیندهای پیام رسانی قرار گیرد. مطالعات کشف دارو (با پرداختن به فراهمی زیستی، پایداری، نفوذ تومور، مشخصات سمیت در بافت‌های غیر بدخیم، تداخلات دارویی، و اثرات خارج از هدف) و درک بیولوژی تومور برای ترجمه بالینی عوامل موثر بر آپوپتوز ضروری است. مرگ سلولی تومور با روش¬های درمانی امکان پذیر است، اما انتخاب، رشد و پراکندگی سلول¬های مقاوم به درمان در نهایت پتانسیل کشندگی را تعیین می کند. هدف از مطالعه حاضر بررسی مسیرهای آپوپتوز اولیه و مسیرهای پیام رسانی مرتبط با آن، به همراه بحث در مورد اهداف مولکولی آن¬ها از منظر درمانی بوده است.
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