Effect of Treatment with Additional Doses of Prostaglandin F2 Alpha during the Middle Stage of the Oestrus Cycle on Luteolysis Process and Reproduction Performance in Holstein Dairy Cows
الموضوعات :
N. Neisari
1
(Department of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran)
A. Kaveh
2
(Department of Clinical Science, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran)
P. Pooladzadeh
3
(Department of Clinical Science, Karaj Branch, Islamic Azad University, Karaj, Iran)
A. Hajibemani
4
(Department of Clinical Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran)
F. Mirzaeei
5
(Department of Medicine, Qazvin University of Medical Science, Qazvin, Iran)
الکلمات المفتاحية: dairy cows, PGF2α, Reproduction performance, luteolysis,
ملخص المقالة :
For the manipulation of the oestrus cycle, the prostaglandin F2 alpha (PGF2α) is a commonly used strategy in dairy cows. The objective of the study was to evaluate the luteolysis response and reproductive performance after treatment with one or two injections of PGF2α. A total of 84 Holstein dairy cows, being in the middle stage of the oestrus cycle (between days 7 and 12) were enrolled in a completely randomized design and divided into three groups: group 1 (n=30), received a single dose of PGF2α injection, whereas, group 2 (n=24) and group 3 (n=30), were treated with two doses of PGF2α injections at 12 and 24 hours intervals, respectively. The corpus luteum diameter was measured using the ultrasound at the beginning, 24, 48 and 72 hours after PGF2α injection. Blood samples were collected to assess progesterone (P4) on day 0 and 72 hours after treatment. Oestrus expression, PGF2α-oestrus interval and first service conception rate were evaluated. The results showed that the luteolysis process, the mean of PGF2α-oestrus interval and progesterone concentration at the beginning (day 0) and 72 hours after treatment were similar for all the groups. Oestrus expression (PGF2α+PGF2α-24 h=76.7% vs. PGF2α+PGF2α-12 h=66.7% and control=56.7%, P>0.05) and the first service conception rate (PGF2α+PGF2α-24 h=41.2% vs. PGF2α+PGF2α-12 h=40.0% and control=33.3%, P>0.05) were relatively higher in cows receiving two doses of PGF2α injections at 24-hour-interval (P>0.05). In conclusion, treatment with an additional dose of PGF2α during the middle stages of the oestrus cycle has no significant effect on luteolysis or reproductive performance.
Ahuja C., Montiel F., Canseco R., Silva E. and Mapes G. (2005). Pregnancy rate following GnRH+ PGF2α treatment of low body condition, anestrous Bos taurus by Bos indicus crossbred cows during the summer months in a tropical environment. Anim. Reprod. Sci. 87, 203-213.
Alnimer M.A., Abedal-Majed M.A. and Shamoun A.I. (2019). Effect of two prostaglandin injections on days 5 and 6 in a timed AI protocol after estrus expression on pregnancy outcomes in dairy cows during cold or hot seasons of the year. Arch. Anim. Breed. 62, 161-168.
Anderson L.E., Wu Y.L., Tsai S.J. and Wiltbank M.C. (2001). Prostaglandin F2α receptor in the corpus luteum: Recent information on the gene, messenger ribonucleic acid, and protein. Biol. Reprod. 64, 1041-1047.
Atanasov B., Dovenski T., Celeska I. and Stevenson J. (2021). Luteolysis, progesterone, and pregnancy per insemination after modifying the standard 7-day Ovsynch program in Holstein-Friesian and Holstein cows. J. Dairy Sci. 104, 7272-7282.
Barletta R., Carvalho P., Santos V., Melo L., Consentini C., Netto A. and Fricke P. (2018). Effect of dose and timing of prostaglandin F2α treatments during a resynch protocol on luteal regression and fertility to timed artificial insemination in lactating Holstein cows. J. Dairy Sci. 101, 1730-1736.
Borchardt S., Pohl A., Carvalho P., Fricke P. and Heuwieser W. (2018). Effect of adding a second prostaglandin F2α injection during the ovsynch protocol on luteal regression and fertility in lactating dairy cows: A meta-analysis. J. Dairy Sci. 101, 8566-8571.
Brusveen D., Souza A. and Wiltbank M. (2009). Effects of additional prostaglandin F2α and estradiol-17β during Ovsynch in lactating dairy cows. J. Dairy Sci. 92, 1412-1422.
Cartmill J., El-Zarkouny S., Hensley B., Lamb G. and Stevenson J. (2001). Stage of cycle, incidence, and timing of ovulation, and pregnancy rates in dairy cattle after three timed breeding protocols. J. Dairy Sci. 84, 1051-1059.
Carvalho P., Fuenzalida M., Ricci A., Souza A., Barletta R., Wiltbank M. and Fricke P. (2015). Modifications to Ovsynch improve fertility during resynchronization: Evaluation of presynchronization with gonadotropin-releasing hormone 6 d before initiation of Ovsynch and addition of a second prostaglandin F2α treatment. J. Dairy Sci. 98, 8741-8752.
Cruppe L., Souto L., Maquivar M., Gunn P., Mussard M., Wolfenson D., Pires A., Bridges G. and Day M. (2010). Use of two coincident doses of PGF2 alpha with the 5-d CO-Synch plus CIDR estrous synchronization program. J. Anim. Sci. 88, 768-768.
Diaz F.J., Anderson L.E., Wu Y.L., Rabot A., Tsai S.J. and Wiltbank M.C. (2002). Regulation of progesterone and prostaglandin F2α production in the CL. Mol. Cell. Endocrinol. 191, 65-80.
El-Zarkouny S., Cartmill J., Hensley B. and Stevenson J. (2004). Pregnancy in dairy cows after synchronized ovulation regimens with or without presynchronization and progesterone. J. Dairy Sci. 87, 1024-1037.
Ginther O. (2007). Color-Doppler Ultrasonography. Equiservices Publishing, Wisconsin, USA.
Ginther O., Araujo R., Palhao M., Rodrigues B. and Beg M. (2009). Necessity of sequential pulses of prostaglandin F2alpha for complete physiologic luteolysis in cattle. Biol. Reprod. 80, 641-648.
Giordano J.O., Fricke P., Wiltbank M. and Cabrera V. (2011). An economic decision-making support system for selection of reproductive management programs on dairy farms. J. Dairy Sci. 94, 6216-6232.
Giordano J.O., Wiltbank M., Guenther J., Ares M., Lopes Jr G., Herlihy M. and Fricke P. (2012a). Effect of presynchronization with human chorionic gonadotropin or gonadotropin-releasing hormone 7 days before resynchronization of ovulation on fertility in lactating dairy cows. J. Dairy Sci. 95, 5612-5625.
Giordano J.O., Wiltbank M., Guenther J., Pawlisch R., Bas S., Cunha A. and Fricke P. (2012b). Increased fertility in lactating dairy cows resynchronized with Double-Ovsynch compared with Ovsynch initiated 32 d after timed artificial insemination. J. Dairy Sci. 95, 639-653.
Giordano J.O., Wiltbank M.C., Fricke P.M., Bas S., Pawlisch R., Guenther J.N. and Nascimento A.B. (2013). Effect of increasing GnRH and PGF2α dose during Double-Ovsynch on ovulatory response, luteal regression, and fertility of lactating dairy cows. Theriogenology. 80, 773-783.
Gümen A., Guenther J. and Wiltbank M. (2003). Follicular size and response to Ovsynch versus detection of estrus in anovular and ovular lactating dairy cows. J. Dairy Sci. 86, 3184-3194.
Kasimanickam R., Day M., Rudolph J., Hall J. and Whittier W. (2009). Two doses of prostaglandin improve pregnancy rates to timed-AI in a 5-day progesterone-based synchronization protocol in beef cows. Theriogenology. 71, 762-767.
Kasimanickam R., Firth P., Schuenemann G.M., Whitlock B., Gay J., Moore D., Hall J. and Whittier W. (2014). Effect of the first GnRH and two doses of PGF2α in a 5-day progesterone-based CO-Synch protocol on heifer pregnancy. Theriogenology. 81, 797-804.
Kayacik V., Salmanoğlu M.R., Polat B. And Özlüer A. (2006). Evaluation of the corpus luteum size throughout the cycle by ultrasonography and progesterone assay in cows. Turkish J. Vet. Anim. Sci. 29, 1311-1316.
Kuru M., Kacar C., Oral H., Kaya S., Cetin N., Kaya D. and Demir M.C. (2020). Effect of two prostaglandin F2α injections administered 24 hours apart on the pregnancy rate of Simmental cows subjected to the Ovsynch or Ovsynch+ Controlled internal drug release (CIDR) protocols. Med. Weter. 76, 660-665.
Levy N., Kobayashi S.I., Roth Z., Wolfenson D., Miyamoto A. and Meidan R. (2000). Administration of prostaglandin F2α during the early bovine luteal phase does not alter the expression of ET-1 and of its type A receptor: A possible cause for corpus luteum refractoriness. Biol. Reprod. 63, 377-382.
Lopez H., Satter L. and Wiltbank M. (2004). Relationship between level of milk production and estrous behavior of lactating dairy cows. Anim. Reprod. Sci. 81, 209-223.
Momont H. and Seguin B. (1984). Influence of day of estrous cycle on response to PGF2 alpha products: implications for AI programs for dairy cattle. Pp. 10-14 in Int. Congr. Anim. Reprod. Art. Insem., University of Illinois at Urbana-Champaign, Illinois, USA.
Mondal M., Schilling B., Folger J., Steibel J.P., Buchnick H., Zalman Y., Ireland J.J., Meidan R. and Smith G.W. (2011). Deciphering the luteal transcriptome: Potential mechanisms mediating stage-specific luteolytic response of the corpus luteum to prostaglandin F2α. Physiol. Genomics. 43, 447-456.
Moreira F., De la Sota R., Diaz T. and Thatcher W. (2000). Effect of day of the estrous cycle at the initiation of a timed artificial insemination protocol on reproductive responses in dairy heifers. J. Dairy Sci. 78, 1568-1576.
Nascimento A.B., Souza A.H., Keskin A., Sartori R. and Wiltbank M.C. (2014). Lack of complete regression of the day 5 corpus luteum after one or two doses of PGF2α in nonlactating Holstein cows. Theriogenology. 81, 389-395.
Peralta O., Pearson R. and Nebel R. (2005). Comparison of three estrus detection systems during summer in a large commercial dairy herd. Anim. Reprod. Sci. 87, 59-72.
Peterson C., Alkar A., Smith S., Kerr S., Hall J., Moore D. and Kasimanickam R. (2011). Effects of one versus two doses of prostaglandin F2 alpha on AI pregnancy rates in a 5-day, progesterone-based, CO-Synch protocol in crossbred beef heifers. Theriogenology. 75, 1536-1542.
Pierson R. and Ginther O. (1984). Ultrasonography of the bovine ovary. Theriogenology. 21, 495-504.
Pieterse M., Taverne M., Kruip T. and Willemse A. (1990). Detection of corpora lutea and follicles in cows: A comparison of transvaginal ultrasonography and rectal palpation. Vet. Record. 126, 552-554.
Pursley J., Wiltbank M., Stevenson J., Ottobre J., Garverick H. and Anderson L. (1997). Pregnancy rates per artificial insemination for cows and heifers inseminated at a synchronized ovulation or synchronized estrus. J. Dairy Sci. 80, 295-300.
Rabaglino M., Risco C., Thatcher M.J., Kim I., Santos J. and Thatcher W. (2010). Application of one injection of prostaglandin F2α in the five-day Co-Synch+ CIDR protocol for estrous synchronization and resynchronization of dairy heifers. J. Dairy Sci. 93, 1050-1058.
Ribeiro E., Bisinotto R., Favoreto M., Martins L., Cerri R., Silvestre F., Greco L., Thatcher W. and Santos J. (2012). Fertility in dairy cows following presynchronization and administering twice the luteolytic dose of prostaglandin F2α as one or two injections in the 5-day timed artificial insemination protocol. Theriogenology. 78, 273-284.
Romano J.E., Thompson J.A., Forrest D.W., Westhusin M.E., Tomaszweski M.A. and Kraemer D.C. (2006). Early pregnancy diagnosis by transrectal ultrasonography in dairy cattle. Theriogenology. 66, 1034-1041.
Santos J., Narciso C., Rivera F., Thatcher W. and Chebel R. (2010). Effect of reducing the period of follicle dominance in a timed artificial insemination protocol on reproduction of dairy cows. J. Dairy Sci. 93, 2976-2988.
Say E., Çoban S., Nak Y., Nak D., Kara U., White S., Kasimanickam V. and Kasimanickam R. (2016). Fertility of Holstein heifers after two doses of PGF2α in 5-day CO-Synch progesterone-based synchronization protocol. Theriogenology. 86, 988-993.
Schams D. and Berisha B. (2004). Regulation of corpus luteum function in cattle–an overview. Reprod. Domest. Anim. 39, 241-251.
Senger P. (1994). The estrus detection problem: New concepts, technologies, and possibilities. J. Dairy Sci. 77, 2745-2753.
Souza A., Gümen A., Silva E., Cunha A., Guenther J., Peto C., Caraviello D. and Wiltbank M. (2007). Supplementation with estradiol-17β before the last gonadotropin-releasing hormone injection of the Ovsynch protocol in lactating dairy cows. J. Dairy Sci. 90, 4623-4634.
SPSS Inc. (2011). Statistical Package for Social Sciences Study. SPSS for Windows, Version 20. Chicago SPSS Inc., USA.
Tippenhauer C., Steinmetz I., Heuwieser W., Fricke P., Lauber M., Cabrera E. and Borchardt S. (2021). Effect of dose and timing of prostaglandin F2α treatments during a 7-d Ovsynch protocol on progesterone concentration at the end of the protocol and pregnancy outcomes in lactating Holstein cows. Theriogenology. 162, 49-58.
Valldecabres-Torres X., García-Roselló E., García-Muñoz A. and Cuervo-Arango J. (2012). Effects of d-cloprostenol dose and corpus luteum age on ovulation, luteal function, and morphology in nonlactating dairy cows with early corpora lutea. J. Dairy Sci. 95, 4389-4395.
Washburn S., Silvia W., Brown C., McDaniel B. and McAllister A. (2002). Trends in reproductive performance in southeastern Holstein and Jersey DHI herds. J. Dairy Sci. 85, 244-251.
Wenzinger B. and Bleul U. (2012). Effect of a prostaglandin F2α analogue on the cyclic corpus luteum during its refractory period in cows. BMC Vet. Res. 8, 220-228.
Wiltbank M., Lopez H., Sartori R., Sangsritavong S. and Gümen A. (2006). Changes in reproductive physiology of lactating dairy cows due to elevated steroid metabolism. Theriogenology. 65, 17-29.
Wiltbank M.C. and Pursley J.R. (2014). The cow as an induced ovulator: Timed AI after synchronization of ovulation. Theriogenology. 81, 170-185.
Wiltbank M.C., Baez G.M., Cochrane F., Barletta R.V., Trayford C.R. and Joseph R.T. (2015). Effect of a second treatment with prostaglandin F2α during the Ovsynch protocol on luteolysis and pregnancy in dairy cows. J. Dairy Sci. 98, 8644-8654.
