Unveiling the potential antidiabetic, antidyslipidemic, and antimicrobial effects of methanolic root extracts of Nymphaea pubescens Willd. plant: Evidence from in-vitro and in-vivo approaches
Subject Areas : Phytochemistry: Isolation, Purification, Characterization
Sahid Ahmad Santo
1
,
Tanmay Deb
2
,
Md. Abdus Salam
3
,
Arafat Miah
4
,
Md. Saddam Hussain
5
,
Anamika Datta
6
,
Mohammad Nurul Amin
7
,
Mohammad Sarowar Uddin
8
,
Mohammad Safiqul Islam
9
,
Md. Shalahuddin Millat
10
*
1 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
2 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
3 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
4 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
5 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
6 - Department of Pharmacy, R. P. Shaha University, Narayanganj-1400, Bangladesh
7 - Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka-1230, Bangladesh
8 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
9 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
10 - Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
Keywords: Antidiabetic, Antihyperlipidemic, Antimicrobial, In vitro, In vivo, Nymphaea pubescens Willd., Nymphaeaceae ,
Abstract :
This study investigated the therapeutic potential of methanolic root extracts of Nymphaea pubescens Willd. with a focus on their antidiabetic, antilipidemic, and antimicrobial properties. The methanolic root extracts of the N. pubescens at higher doses (500 mg/kg) exhibited a pronounced serum blood glucose-lowering activity (p < 0.001) and also demonstrated remarkable outcomes in body weight loss (p < 0.01), closely resembling the effects of the standard metformin. The same experiment displayed a noticeable reduction in low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels (p < 0.001), along with a notable elevation in high-density lipoprotein cholesterol (HDL-C) levels (p < 0.01). Furthermore, the plant extract at 500 mg/kg unveiled significant antimicrobial activities (p < 0.001) against both Staphylococcus aureus and Aspergillus niger and also exhibited significant (p < 0.01) inhibition of Escherichia coli. In summary, these findings highlight the multifaceted therapeutic potential of N. pubescens root extracts, warranting further investigation for their possible development into novel therapeutic agents.
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