تاثیر مصرف مکمل کوئرستین بر CRP و IL-6 پس از یک جلسه تمرین مقاومتی وامانده ساز در مردان جوان
محورهای موضوعی : مجله پلاسما و نشانگرهای زیستی
خلیل محمودی
1
(فلوشیپ اینترونشنال کاردیولوژی و عضو هیات علمی دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان، زنجان، ایران.)
خلیل اله منیخ
2
(فیزیولوژی ورزشی، دانشگاه تربیت دبیر شهید رجایی، تهران، ایران)
فرامرز یزدانی
3
(فیزیولوژی ورزشی، دانشگاه تربیت دبیر شهید رجایی، تهران، ایران)
کلید واژه: کوئرستین, التهاب, تمرین مقاومت وامانده ساز,
چکیده مقاله :
زمینه و هدف:فعالیتهایشدید بدنیموجب افزایشتولید شاخص های التهابی میشود،کهمىتواندسلامتو عملکرد ورزشکارانرابهمخاطرهبیندازد. کوئرستینیکفلاونوئیدباخواصآنتیاکسیدانیوضدالتهابیاست. بنابراین، مطالعه حاضر به منظور بررسی اثر مصرف مکمل کوئرستین بر CRP و IL-6متعاقب یک جلسه فعالیت مقاومتی وامانده ساز صورت گرفت. روش کار: این کارآزمایی بالینی دو سوکور کنترل شده با دارونما در 22 مرد جوان به مدت هفت روز انجام شد. افراد به صورت تصادفی در یکی از دو گروه کوئرستین(1000میلی گرم) و دارونما(1000میلی گرم دکستروز) قرار گرفتند. اندازهگیرىهاىپیکرسنجى و آزمایشهاىبیوشیمیایىخون(CRP و IL-6) درابتداوانتهاىمطالعهانجام شد. تجزیه و تحلیل داده های به دست آمده با استفاده از آزمون آماری آنالیز واریانس با اندازه های تکراری(2×2) انجام وسطحمعنیداری 05/0>p0منظورگردید یافته ها:درانتهاىمطالعهدرگروه دارونماغلظت CRP و IL-6 سرم نسبت به پیش آزمون افزایش معنی دار یافت(05 /0>p). ولی در گروه مکمل کوئرستین این تغییرات معنی دار نبود. میانگیناین شاخص هادرانتهاىمطالعهبیندوگروهتفاوتمعنادارىبایک دیگرداشتند(05 /0>p). نتیجه گیری: نتایج حاصل از این مطالعه نشان داد که کوئرستین در پیشگیری از التهاب پس از ورزش مقاومتی وامانده ساز در مردان جوان موثر است.
1.Aguirre, L., Arias, N., Macarulla, MT., Gracia, A., Portillo, MP. (2011). Beneficial effects of quercetin on obesity and diabetes. Open Nutraceuticals J, 4; 189-98.
2.Albert, MA., Glynn, RJ., Ridker, PM. (2004). Effect of physical activity on serum Creactive protein. Am J Cardiol, 93; 221-5.
3.Askari, G., Ghiasvand, R., Feizi, A., Ghanadian, SM., Karimian, J. (2012). The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J Res Med Sci, 17; 637-41.
4.Askari, G., Ghiasvand, R., Hajishafiee, M., Akbari, F. (2012). The effects of quercetin supplementation on endothelial function, oxidative stress, athletic performance, inflammatory biomarkers and muscle damage indices in athletes. Journal of Isfahan Medical School, 29(165); 222-230.
5.Barquilha, G., Uchida, M., Santos, V., Moura, N., Lambertucci, R., Hatanaka, E. (2011). Characterization of the effects of one maximal repetition test on muscle injury and inflammation markers. Web Medcentral Physiol, 2(3); 1-8.
6.Barzinjah, SP., Dabidy Roshan, V. (2015). Effects of ginger root on inflammatory and anti-inflammatory response induced by Delorme resistance training in male volleyball players. Scientific Journal of Kurdistan University of Medical Sciences, 21; 89-99.
7.Bizheh, N., Rashidlamir, A., Zabihi, A., Jaafari, M. (2011). The acute effects of strength training on inflammatory markers predicting atherosclerosis: a study on inactive middle-aged men. Tehran University Medical Journal, 69(3); 204-209.
8.Boots, AW., Wilms, LC., Swennen, EL., Kleinjans, JC., Bast, A., Haenen, GR. (2008). In vitro and ex vivo anti‑inflammatory activity of quercetin in healthy volunteers. Nutrition, 24; 703‑10.
9.Brzycki, M. (1993). Strength testing-predicting a one-rep maxfrom a reps-to-fatigue. J. Phys. Health Edu. Recreat.Dance, 64(1); 88-90.
10.Coffey, VG., Reeder, DW., Lancaster, GI., Yeo, WK., Febbraio, MA., Yaspelkis, BB., Hawley, JA. (2007). Effect of high-frequency resistance exercise on adaptive responses in skeletal muscle. Medicine & Science in Sports & Exercis, 39(12); 2135-2144.
11.Duzova, H., Karakoc, Y., Emre, MH., Dogan, ZY., Kilinc, E. (2009). Effects of acute moderate and strenuous exercise bouts on IL-17 production and inflammatory response in trained rats. Journal of Sports Science and Medicine, 8(2); 219-224.
12.Egert, S., Bosy‑Westphal, A., Seiberl, J., Kürbitz, C., Settler, U., Plachta‑Danielzik, S. (2009). Quercetin reduces systolic blood pressure and plasma oxidised low‑density lipoprotein concentrations in overweight subjects with a high‑cardiovascular disease risk phenotype: A double‑blinded, placebo‑controlled cross‑over study. Br J Nutr, 102;1065‑74.
13.Erdman, JW Jr., Balentine, D., Arab, L., Beecher, G., Dwyer, JT., Folts, J. (2007). Flavonoids and heart health. In: proceedings of the ILSI north america flavonoids workshop. J Nutr, 137; 718S‑37.
14.Fatouros, I., Chatzinikolaou, A., Paltoglou, G., Petridou, A., Avloniti, A., Jamurtas, A. (2010). Acute resistance exercise results in catecholaminergic rather than hypothalamic-pituitary-adrenal axis stimulation during exercise in young men. Stress, 13(6); 461-468.
15.Garcia-Mediavilla, V., Crespo, I., Collado, PS., Esteller, A., Sanchez-Campos, S., Tunon, MJ. (2007). The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappa B pathway in Chang Liver cells. Eur J Pharmacol, 557(2-3); 221-9.
16.Goktepe, M., Gunay, M. (2012). The effect of quercetin administration on exercise, free radical and antioxidant enzym levels. J Nutrition, 1; 2148-1148.
17.Hirose, L., Nosaka, K., Newton, M., Laveder, A., Kano, M., Peake, JM. (2004). Changes in inflammatory mediators following eccentric exercise of the elbow flexors. Exerc Immunol Rev, 10; 75-90.
18.Hojjat, Sh., Sirvan, A., Goly, MA. (2014). The impact of omega-3 fatty acid supplementation on inflammatory marker CRP and serum markers of cell damage after a bout of resistance exercise in young male handball players. Journal of Sports Sciences, 11(5); 159-175.
19.Kasapis, C., Thompson, PD. (2005). The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol, 45(10); 1563-9.
20.Kempf, K., Herder, C., Erlund, I. (2010). Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr, 91; 950-7.
21.Kevin, S., Fallon, O., Diksha Kaushik, B., Michniak-Kohn, C., Patrick Dunne, E., Zambraski, J. (2012). Clarkson. effects of quercetin supplementation on markers of muscle damage and inflammation after eccentric exercise. International Journal of Sport Nutrition and Exercise Metabolism, 22; 430 -437.
22.Konrad, M., Nieman, DC., Henson, DA., Kennerly, KM., Jin, F., Wallner-Liebmann, SJ. (2011). The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. International Journal of Sport Nutrition and Exercise Metabolism, 21(4); 338-346.
23.Kraemer, WJ., Adams, K., Cafarelli, E., Dudley, GA., Dooly, C. (2002). Progression models in resistance training for healthy adults. Med Sci Sports Exerc, 34(2); 364-80.
24.Lisa, S., Mc Anulty, Lindsey, E., Miller, Peter, A., Hosick, Alan C., Utter, John C., Steven R. (2013). Effect of resveratrol and quercetin supplementation on redox status and inflammation after exercise. Appl. Physiol. Nutr. Metab, 38; 760–765.
25.Moonikh, KH., Kashef, M., Azad, A. (2015). Effects of 6 weeks resistance training on Body Composition, Leptin and muscle strength in non-athletic men. J ofoge danesh, 21(2); 135-140. [Farsi]
26.Nieman, DC. (2010). Quercetin’s bioactive effects in human athletes .Current Topics Innutraceutical Research, 8, (1); 33-43.
27.Nieman, DC., Henson, DA., Gross, SJ., Jenkins, DP., Davis, JM., Murphy, EA. (2007). Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc, 39(9); 1561-9.
28.Nieman, DC., Henson, DA., Maxwell, KR., Williams, AS., McAnulty, SR., Jin, F. (2009). Effects of quercetin and EGCG on mitochondrial biogenesis and immunity. Med Sci Sports Exerc, 41(7); 1467-75.
29.Overman, A., Chuang, CC., McIntosh, M. (2011). Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media. International Journal of Obesity, 35(9); 1165–1172.
30.Pearson, TA., Mensah, GA., Alexander, RW., Anderson, JL., Cannon, RO., Criqui, YY. (2003). Markers of inflammation and cardiovascular disease. Circulation, 107(3); 499–511.
31.Phillips, T., Childs, AC., Dreon, DM., Phinney, S., Leeuwenburgh, C. (2003). A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Medicine and Science in Sports and Exercisو 35(12): 2032–2037.
Pikulski M, Brodbelt JS. Differentiation of flavonoid glycoside ısomers by using metal complexation and electrospray ıonization mass spectrometry. J am soc mass spectrom. 2003; 14(12); 1437-53.
32.Punduk, Z., Hismiogullari, AA., Yavuz, O., Rahman, K. (2015). The dietary combination of quercetin and resveratrol supplementation may improve exercise tolerance in young untrained males by modulating il-6 and ngal response. American Journal of Sports Science, 3(2); 29-35.
33.Ramezani, A., Moonikh, K. (2017). Effect of quercetin supplementation on oxidative stress and exhaustion in male soccer players. JMP, 2(62); 136-144.
34.Rivera, L., Morón, R., Sánchez, M., Zarzuelo, A., Galisteo, M. (2008). Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring), 16; 2081‑7.
35.Steven, R., McAnulty, Lisa S., McAnulty, David C., Nieman, John C., Quindry, Peter A., Hosick, Matthew H. (2008). Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. Appl. Physiol. Nutr. Metab, 33(2); 254-262.
36.Suen, J., Thomas, J., Kranz, A., Vun, S., Miller, M. (2016). Effect of flavonoids on oxidative stress and inflammation in adults at risk of cardiovascular diseasea systematic. Review. Healthcare, 144(3); 278-83.