تاثیر پیش شرطي سازي به وسیله تمرین هوازي و هوازي - شناختی بر سطوح پروفايل هاي لیپیدي خطرزا و سطوح هموسیستئین در رت‌های سالمند مبتلا زوال عقل
محورهای موضوعی : مطالعات نوین در متابولیسم ورزش و فعالیت بدنیعلیرضا صفری 1 , مصطفی تیموری خروی 2
1 - دانشجو
2 - استادیار، گروه تربیت بدنی و علوم ورزشی، واحد بجنورد،دانشگاه آزاد اسلامی، بجنورد، ایران
کلید واژه: زوال عقل, زوال عقل عروقی, هموسیستئین, لیپیدهای سرم,
چکیده مقاله :
مقدمه: زوال عقل عروقي از شایع‌ترین بیماری‌های ارگانیک مغز بوده كه منشا بسياري ديگر از بيماري هاي وابسته به مغز مي باشد. لیپیدهای سرمی و هموسیستئین از جمله ریسک فاکتورهای موثر بر زوال عقل عروقی هستند. هدف مطالعه حاضر تاثیر پیش آماده‌سازی بوسیله تمرین استقامتی و استقامتی شناختی بر سطوح لیپیدهای سرمی، هموسیستئین سرم پس از ابتلا به زوال عقل عروقی می‌باشد. روش ها: برای این منظور 40 سرموش صحرایی نر سالمند به صورت تصادفی به چهار گروه 10 تایی، کنترل سالم، گروه زوال عقل، گروه استقامتی و گروه استقامتی شناختی تقسیم شدند. موش ها در گروه های استقامتی و استقامتی شناختی بعد از 8 هفته تمرین ورزشی به زوال عقل عروقی مبتلا شدند. پروتکل تمرین در گروه تمرین هوازي شناختی شامل تمرین در ماز آبی موریس برای هر رت به مدت 3 هفته و در هر هفته 3 روز و در هر روز 4 بار با فاصله 10 دقيقه تمرین بود. پروتکل تمرین در گروه تمرین هوازي نيز شامل تمرين براي مدت 3 هفته و هر هفته 5 روز و هر روز به مدت 30 دقیقه در استخر مخصوص جوندگان بود. برای اندازه گیری سطوح سرمی هموسیستئین و فاکتورهای لیپیدی از کیت‌های اندازه‌گیری مخصوص آن‌ها استفاده شد. داده‌ها با استفاده از آزمون تحليل واريانس يک راهه و آزمون تعقيبي بونفروني تجزيه وتحليل شد. یافته ها: یافته‌ها نشان داد پیش آماده‌سازی با تمرین استقامتی و تمرین استقامتی شناختی باعث كاهش معناداري در TC، TG و هموسیستئین و همچنين باعث افزايش معنادار HDL شد(P≤0.05). نتيجه گيري: به نظر می رسد پیش آماده سازی بوسیله تمرینات استقامتی و استقامتی شناختی می تواند باعث کاهش سطوح هموسیستئین سرم و کاهش فاکتورهای لیپیدی به عنوان عوامل خطرزاي شناخته شده در بيماري زوال عقل شود. كلمات كليدي: زوال عقل؛ زوال عقل عروقی؛ هموسیستئین؛ لیپیدهای سرمی
Introduction: Dementia is one of the most common organic diseases of the brain, which is the origin of many other brain-related diseases. Serum lipids and homocysteine are among the judgments of life dementia research factors. The aim of the present study is the effect of pre-training by endurance and cognitive endurance training on the level of serum lipids, after being diagnosed with dementia. Methods: For this purpose, 40 elderly male rats were randomly divided into four groups of 10, healthy control, dementia group, endurance group and cognitive endurance group. Mice in endurance and cognitive endurance groups became dementia patients after 8 weeks of exercise training. The training protocol in the aquatic aerobic training group included training in the Morris Maze for each rat for 3 weeks, 3 days per week, and 4 times per day with a 10-minute training interval. The training protocol in the aerobic training group also included training for 3 weeks, 5 days each week, and 30 minutes each day in the rodent pool. Special measurement kits are used to measure serum levels of homocysteine and lipid factors. Data were analyzed using one-way analysis of variance and Bonferroni post hoc test. Findings: The findings showed that pre-training with endurance training and cognitive endurance training caused a significant decrease in TC, TG and homocysteine and the findings caused a significant increase in HDL (P≤0.05). Conclusion: It seems that preparation by endurance and endurance exercises can reduce serum homocysteine level and reduce lipid factors
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