High intensity endurance training improves metabolic syndrome in men with type 2 diabetes mellitus
Subject Areas : Journal of Physical Activity and Hormones
Mohadeseh
Nematollahzadeh
1
(MS in Exercise physiology, Education Administration in Shiraz)
Rahim
Shirazi-nezhad
2
(Department of Exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran)
Keywords: Insulin resistance, Diabetes, Metabolic syndrome, High intensity endurance exercise,
Abstract :
Introduction: Metabolic syndrome (MS) is a defined cluster of cardiometabolic abnormalities that increases an individual’s risk of type 2 diabetes mellitus (T2DM). The purpose of this study was to examine the effect of 12 weeks high intensity exercise training on MS in men with T2DM. Material & Methods: Sixteen sedentary overweight and obese middle-aged men (aged: 41.18 ± 6.1 years; ± SD) volunteered to participate in this study. The subjects were randomly assigned to training group (n=8) or control group (n=8). The training group performed endurance training 4 days a week for 12 weeks at an intensity corresponding to 75-80% individual heart rate reserve (HRR) for 45 min. Results: The results showed that waist circumference (WC) as well as triglycerides (TG), blood pressure (BP) and glucose were decreased in the training group compared to the control group (P<0.05). After 12 weeks, the training group resulted in a significant increase (P<0.05) in the high-density lipoprotein cholesterol (HDL-C) in compared with the control group (P<0.05). Conclusions: In conclusion, high intensity endurance training improves metabolic syndrome in men with T2DM.
1. World Health Organization Obesity and Overweight: World Health Organization global strategy on diet, physical activity and health fact sheet. Available online at: http://www.who.int. Accessed September 16, 2005.
2. Wyatt SB, Winters KP, Dubbert PM. Overweight and obesity: prevalence, consequences, and causes of a growing public health problem. Am J Med Sci 2006; 331: 166-174.
3. Williams PT. High-density lipoprotein cholesterol and other risk factors for coronary heart disease in female runners. N Engl J Med 1996; 334: 1298-1303.
4. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 2003; 106: 3143-3421.
5. Katzmarzyk PT, Church TS, Janssen I, Ross R, Blair SN. Metabolic Syndrome, Obesity, and Mortality: Impact of cardiorespiratory fitness. Diabetes Care 2005; 28: 391-397.
6. Snowling NJ, Hopkins WG. Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients: a meta-analysis. Diabetes Care 2006; 29: 2518-2527.
7. Winnick JJ, Sherman WM, Habash DL, Stout MB, Failla ML, Belury MA, Schuster DP. Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. J Clin Endocrinol Metab 2008; 93: 771-778.
8. Kelley GA, Kelley KS. Effects of aerobic exercise on lipids and lipoproteins in adults with type 2 diabetes: a meta-analysis of randomized-controlled trials. Public Health 2007; 121: 643-655.
9. Chudyk A, Petrella RJ. Effects of exercise on cardiovascular risk factors in type 2 diabetes: a meta-analysis. Diabetes Care 2011; 34: 1228-1237.
10. Honkola A, Forsen T, Eriksson J. Resistance training improves the metabolic profile in individuals with type 2 diabetes. Acta Diabetol 1997; 34: 245-248.
11. Hayashino Y, Jackson JL, Fukumori N, Nakamura F, Fukuhara S. Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Diabetes Res Clin Pract 2012; 98: 349-360.
12. Pi-Sunyer X, Blackburn G, Brancati FL, Bray GA, Bright R, Clark JM, et al. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care 2007; 30: 1374-1383.
13. Wing RR. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med 2010; 170: 1566-1575.
14. Bouchard C, Tremblay A, Leblanc C, Lortie G, Savard R, Thériault G. A method to assess energy expenditure in children and adults. Am J Clin Nutr 1983; 37: 461-467.
15. Emoto M , Nishizawa Y, Maekawa K, Hiura Y, Kanda H, Kawagishi T, et al. Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care 1999; 22: 818-822.
16. Paul AA, Southgate DAT. Mccance and widdowson’s the composition of foods. H M S O (Lond) 4th Ed, 1978.
17. American College of Sport Medicine. Guidelines for exercise testing and prescription. Philadelphia: Lippincott Williams & Wilkins, pp 57-90, 2005.
18. Inaba M, Kurajoh M, Okuno S, Imanishi Y, Yamada S, Mori K, et al. Poor muscle quality rather than reduced lean body mass is responsible for the lower serum creatinine level in hemodialysis patients with diabetes mellitus. Clin Nephrol 2010; 74: 266-272.
19. Hayashino Y, Jackson JL, Fukumori N, Nakamura F, Fukuhara S. Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Diabetes Res Clin Pract 2012; 98: 349-360.
20. Madden KM. Evidence for the benefit of exercise therapy in patients with type 2 diabetes. Diabetes Metab Syndr Obes 2013; 6: 233-239.
21. Lewis GF, Steiner G. Hypertriglyceridemia and its metabolic consequences as a risk factor for atherosclerotic cardiovascular disease in non-insulin dependent diabetes mellitus. Diabetes Metab Rev 1996; 12: 37-56.
22. Loh KC, Thai AC, Lui KF, Ng WY. High prevalence of dyslipidaemia despite adequate glycaemic control in patients with diabetes. Ann Acad Med Singapore 1996; 25: 228-232.
23. Steiner G, Stewart D, Hosking JD. Baseline characteristics of the study population in the Diabetes Atherosclerosis Intervention Study (DAIS). World Health Organization Collaborating Centre for the Study of Atherosclerosis in Diabetes. Am J Cardiol 1999; 84: 1004-1010.
24. Lampman RM, Schteingart DE. Effects of exercise training on glucose control, lipid metabolism, and insulin sensitivity in hypertriglyceridemia and non-insulin dependent diabetes mellitus. Med Sci Sports Exerc 1991; 23: 703-712.
25. Durstine JL, Haskell WL. Effects of exercise on plasma lipids and lipoproteins. Exerc Sport Sci Rev 1994; 22: 477-521.
26. American Diabetes Association. ADA stand position: physical activity/exercise and diabetes mellitus. Diabetes Care 2003; 26: 573-577.
27. Blomhoff JP. Lipoproteins, lipases, and the metabolic cardiovascular syndrome. Cardiovasc Pharmacol 1992; 20: S22-S25.
28. Marandi MS, Abadi BN, Esfarjani F, Mojtahedi H, Ghasemi G. Effects of intensity of aerobics on body composition and blood lipid profile in obese/ overweight females. Iran Int Sports Med Congr 2013; 4: 118-125.
29. Calabresi L, Franceschini G. Lecithin: Cholesterol Acyltransferase, High-Density Lipoproteins, and Atheroprotection in Humans. Trends Cardiovasc Med 2010; 20: 50-53.
30. Warburton DE, Nicol CW, Bredin SS. Health benefits of Physical activity: the evidence. CMAJ 2006: 174: 801-809.
31. Wareman NJ, Wong MY, Hennins S, Mitchell J, Rennie K, Cruickshank K, et al. Quantifying the association between habitual energy expenditure and blood pressure. Int J Epidemiol 2000; 29: 655-660.
32. Gordon NF, Scott CB, Wilkinson WJ, Duncan JJ, Blair SN. Exercise and mild hypertension. Recommendations for adults. Sports Med 1990; 10: 390-404.
33. Paffenbarger RS, Jung DL, Leung RW, Hude RT. Physical activity and hypertension: an epidemiological view. Ann Med 1991; 23: 319-327.
34. Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med 2002; 136: 493- 503.
35. Dobrosielski DA, Gibbs BB, Ouyang P, Bonekamp S, Clark JM, Wang NY, et al. Effect of exercise on blood pressure in type 2 diabetes: a randomized controlled trial. J Gen Intern Med 2012; 27: 1453-1459.
36. Snowling NJ, Hopkins WG. Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients: a meta-analysis. Diabetes Care 2006; 29: 2518-2527.
37. Tabata I, Suzuki Y, Fukunaga T, Yokozeki T, Akima H, Funato K. Resistance training affects GLUT-4 content in skeletal muscle of humans after 19 days of head-down bed rest. J Appl Physiol 1999; 86: 909-914.
38. Etgen GJ Jr, Jensen J, Wilson CM, Hunt DG, Cushman SW, Ivy JL. Exercise training reverses insulin resistance in muscle by enhanced recruitment of GLUT-4 to the cell surface. Am J Physiol 1997; 272: E864-E869.