Brain derived neurotrophic factor of adolescents not improved after 8 weeks resistance training

Subject Areas : Journal of Physical Activity and Hormones

Fatemeh  Dalaeli ¹ (Department of Exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran)
Rahim  Shirazi-nezhad ² (Department of Exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran)

Received: 2017-05-30 Accepted : 2017-07-23 Published : 2017-09-01

Keywords: Resistance training, adolescents, BDNF, Brain health,

Abstract :

Introduction: Although the benefits of physical activity on cardiovascular health are well known, recent evidence demonstrated that exercise may promote brain health by increases brain derived neurotrophic factor (BDNF); however it is still unclear. The purpose of this study was to examine the effects of 8 weeks resistance training on serum BDNF levels in adolescents. Material & Methods: Twenty four adolescents (age, 16 to 18 years) were randomly assigned to one of the training group (n=12) or control group (n=12). The training group was performed resistance training 3 days a week for 8 weeks in 2-3 sets with 12-15 maximal repetitions at 60-75% of 1-RM in each station. Biochemical parameters were measured before and 48h after the last session of training. Results: The results indicated that body fat percent decreased after 8 weeks resistance training (P<0.05); however, serum BDNF had no significant changes after the intervention. Conclusions: Serum BDNF level was not affected by 8 weeks resistance training in the adolescents.

References:

1. Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, et al. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med 2006; 144: 73-81.

2. Cassilhas RC, Viana VA, Grassmann V, Santos RT, Santos RF, Tufik S, et al. The impact of resistance exercise on the cognitive function of the elderly. Med Sci Sports Exerc 2007; 39: 1401-1407.

3. Winter B, Breitenstein C, Mooren FC, Voelker K, Fobker M, Lechtermann A, et al. High impact running improves learning. Neurobiol Learn Mem 2007; 87: 597-609.

4. Grego F, Vallier JM, Collardeau M, Rousseu C, Cremieux J, Brisswalter J. Influence of exercise duration and hydration status on cognitive function during prolonged cycling exercise. Int J Sports Med 2005; 26: 27-33.

5. Ferris LT, Williams JS, Shen CL. The effect of acute exercise on serum brain derived neurotrophic factor levels and cognitive function. Med Sci Sports Exerc 2007; 39: 728-734.

6. Tomporowski PD. Effects of acute bouts of exercise on cognition. Acta Psychol (Amst) 2003; 112: 297-324.

7. Chen HI, Lin LC, Yu L, Liu YF, Kuo YM, Huang AM, et al. Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system. Neurobiol Learn Mem 2008; 89: 489-496.

8. Griffin EW, Bechara RG, Birch AM, Kelly AM. Exercise enhances hippocampal-dependent learning in the rat: evidence for a BDNF-related mechanism. Hippocampus 2009; 19: 973-980.

9. Chiaramello S, Dalmasso G, Bezin L, Marcel D, Jourdan F, Peretto P, et al. BDNF/TrkB interaction regulates migration of SVZ precursor cells via PI3-K and MAP-K signalling pathways. Europ J Neurosci 2007; 26: 1780-1790.

10. Nakagawa T, Tsuchida A, Itakura Y, Nonomura T, Ono M, Hirota F, et al. Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes 2000; 49: 436-444.

11. Gold SM, Schulz KH, Hartmann S, Mladek M, Lang UE, Hellweg R, et al. Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls. J Neuroimmunol 2003; 138: 99-105.

12. Rojas Vega S, Struder HK, Vera Wahrmann B, Schmidt A, Bloch W, Hollmann W. Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans. Brain Res 2006; 1121: 59-65.

13. Tang SW, Chu E, Hui T, Helmeste D, Law C. Influence of exercise on serum brainderived neurotrophic factor concentrations in healthy human subjects. Neurosci Lett 2008; 431: 62-65.

14. Marston KJ, Newton MJ, Brown BM, Rainey-Smith SR, Bird S, Martins RN, et al. Intense resistance exercise increases peripheral brain-derived neurotrophic factor. J Sci Med Sport 2017. (Epub ahead of print)

15. Antonio-Santos J, Ferreira DJ, Gomes Costa GL, Matos RJ, Toscano AE, Manhães-de-Castro R, et al. Resistance Training Alters the Proportion of Skeletal Muscle Fibers but Not Brain Neurotrophic Factors in Young Adult Rats. J Strength Cond Res 2016; 30: 3531-3538.

16. Zare Mehrjardi R. Effect of 8 weeks moderate intensity aerobic exercise on brain derived neurotrophic factor (BDNF) in female athletes. J Physical Act Hormone 2017; 1: 29-38.

17. Tang SW, Chu E, Hui T, Helmeste D, Law C. Influence of exercise on serum brain‐derived neurotrophic factor concentrations in healthy human subjects. Neurosci Lett 2008; 431: 62-65.

18. Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, et al. Evidence for a release of brain‐derived neurotrophic factor from the brain during exercise. Exp Physiol 2009; 94: 10621069.

19. Lee IT, Wang JS, Fu CP, Lin SY, Sheu WH. Relationship between body weight and the increment in serum brain-derived neurotrophic factor after oral glucose challenge in men with obesity and metabolic syndrome: A prospective study. Medicine (Baltimore) 2016; 95: e5260.

20. Carroll TJ, Barry B, Riek S, Carson RG. Resistance training enhances the stability of sensorimotor coordination. Proc Biol Sci 2001; 268: 221-227.

21. Carroll TJ, Riek S, Carson RG. The sites of neural adaptation induced by resistance training in humans. J Physiol 2001; 544: 641-652.