Development and Evaluation of Nanomagnetic Carrier for the Controlled Loading and Release of Celecoxib

Subject Areas : Bio Materials

Shabnam Ahmadvand ¹ , Maryam Kargar Razi ² , Babak Sadeghi ³ , Seyedeh Sara Mirfazli ⁴

1 - Department of Chemistry, Islamic Azad University, North Tehran Branch, Tehran, Iran
2 - Department of Chemistry, Islamic Azad University, North Tehran Branch, Tehran, Iran
3 - Department of Chemistry, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran
4 - Department of Medicinal Chemistry, School of Pharmacy International Campus, Iran University of Medical Sciences, Tehran, Iran

Received: 2021-10-22 Accepted : 2021-12-19 Published : 2022-01-01

Keywords: nanocomposite, TGA, Magnetite, Celecoxib, Dynamic Light Scattering (DLS),

Abstract :

The aim of the present study was to develop synthesize, characterize, and find many applications of functionalized metal oxide nanoparticles. Herein, a new strategy is developed to functionalize magnetite nanoparticles to improve their performances of cerium oxide-functionalized Fe3O4@SiO2@CeO2 magnetic nanoparticles (FSC). In this study, after preparing optimized FSC, characterization and identification of their chemical structure were carried out by FT-IR, FESEM, VSM, TGA, DLS, and XRD. Afterward, the functionalized nanoparticles were examined in the delivery of celecoxib as an active drug model involving cerium oxide and hydroxyl functional groups. The results with respect to particle size, present investigation indicate that the formulations (mFSC=5 mg, pH=3.3) can be considered as best among various formulations. Dynamic light scattering (DLS) techniques used to measure particle size and zeta potential distribution revealed successful preparation of an Fe3O4@SiO2@CeO2 nanocomposite prepared on Fe3O4@SiO2 (FS), with a hydrodynamic size distribution of 45 nm.

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