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Open Access Article
1 - Simultaneous spectrophotometric determination of lidocaine and hydrocortisone acetate in pharmaceutical preparations by multivariate calibration methods
Amir H.M. Sarrafi Manochehr Bahmaei Assieh Z. MousaviThe multivariate calibration method, partial least square regression (PLS) was applied for thesimultaneous spectrophotometric determination of Lidocaine (LID) and Hydrocortisone acetate(HCA) in their mixtures. The parameters of chemometric technique were optimized and t MoreThe multivariate calibration method, partial least square regression (PLS) was applied for thesimultaneous spectrophotometric determination of Lidocaine (LID) and Hydrocortisone acetate(HCA) in their mixtures. The parameters of chemometric technique were optimized and theproposed method was validated with synthetic samples and applied to analyze these drugs inpharmaceutical products with good accuracy and precision. The results were compared with theHPLC method. The squares of correlation coefficients (R2) for predicted LID and HCA with theproposed method in test samples were 0.9970 and 0.9964, respectively. The relative standarddeviations for commercial products were less than 1%. Manuscript profile -
Open Access Article
2 - The determination of Cu2+, Fe3+, Zn2+ and Pb2+ in real samples by flame atomic absorption spectrometry after their separation- preconcentration on 2-(2-nitrophenylazo)- naphthalen-1-ol loaded on activated carbon
Amir H. M. Sarrafi Elahe Konoz Kobra ShabaniA sensitive and simple method for simultaneous preconcentration of trace heavy metal ions in some cerealand vegetable samples has been reported. The method is based on the adsorption of Cu2+, Fe3+, Zn2+ and Pb2+on 2-(2-nitro-phenylazo)-naphthalen-1-ol (NPN) loaded on ac MoreA sensitive and simple method for simultaneous preconcentration of trace heavy metal ions in some cerealand vegetable samples has been reported. The method is based on the adsorption of Cu2+, Fe3+, Zn2+ and Pb2+on 2-(2-nitro-phenylazo)-naphthalen-1-ol (NPN) loaded on activated carbon (AC). The adsorbed metals onactivated carbon were eluted using 3 ml 4 mol L−1 nitric acid. The influences of the analytical parametersincluding pH, flow rate of sample and eluent, type and concentration of eluent, amount of adsorbent andsample volume were investigated. The effects of matrix ions on the recoveries of analyte ions were alsoinvestigated. The recoveries of analytes were generally higher than 95%. The detection limits for Cu2+, Fe3+,Zn2+ and Pb2+ were 0.17 μg L-1 , 0.16 μg L-1 ,0.11 μg L-1 and 0.12 μg L-1 respectively. Manuscript profile
List of Articles Amir H.M. Sarrafi
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