Histopathological evidences for effect beneficial of Satureja hortensis extract on hepatic lesion by cadmium–induced in Rat
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)
الهام مقتدایی خوراسگانی
1
,
عبداله قاسمی پیربلوطی
2
,
ش. ادیبی
3
1 - گروه پاتولوژی، دانشکده دامپزشکی، دانشگاه ازاد واحد شهرکرد، شهرکرد، ایران
2 - مرکز پژوهش های گیاهان دارویی و دام پزشکی سنتی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران؛
بخش تحقیقات گیاهان دارویی، دانشکده کشاورزی استاکبریج، کالج علوم طبیعی، دانشگاه ایالتی ماساچوست، آمریکا
3 - مرکز تحقیقات دامپزشکی ترابی نژاد، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
Keywords: Cadmium, Medicinal herbs, aspartate transminase (AST), alanine transaminase (ALT), Liver histopathology,
Abstract :
Background & Aim:Cadmium is an important industrial and environmental pollutant. Cadmium is one of the most toxic and carcinogenic heavy metals to organisms. This heavy metal mainly distributes to the liver and kidney in humans and animal and, causing acute hepatic injury. Experimental: The ethanol extract of Satureja hortensis L. (Lamiaceae family), was evaluated for its activity against cadmium–induced in male Wister rats (150 – 180 g). The ethanol extract of S. hortensis (100 and 200 mg/kg/day for six weeks) was examined on serum bicochemical and hepatic histopathological characteristic of rats subcutaneously received with cadmium chloride (CdCl2) at 3 mg/kg/day for six weeks. Results: The biochemical results indicated that aspartate transminase (AST) and alanine transaminase (ALT) significantly increased in serum by cadmium–induced. The liver histopathological results revealed that the ethanol extract of S. hortensis treatment at 200 mg/kg/day significantly reduced toxicity by cadmium–induced. The ethanol extract of S. hortensis prevents the cadmium–induced lesions in hepatic function. Recommended applications/industries: Known antioxidant, antimicrobial, antihepatotoxic, nephroprotective potentials of the extract of S. hortensis may be the mechanisms by which this plant protects animals against experimentally cadmium–induced.
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