The effect of Hypericum scabrum on the hematologic factors, body weight and temperature in mice
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)عبدالله قاسمی پیربلوطی 1 , محسن جعفریان دهکردی 2 , رحمان پورحکیم داودی 3 , بهزاد حامدی 4 , محمد ربیعی 5
1 - مرکز پژوهش‌های گیاهان دارویی و دامپزشکی سنتی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران
2 - گروه کلینکال پاتولوژی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران؛
3 - گروه کلینکال پاتولوژی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران؛
4 - مرکز پژوهش‌های گیاهان دارویی و دامپزشکی سنتی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران
5 - مرکز پژوهش‌های گیاهان دارویی و دامپزشکی سنتی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران
Keywords: body weight, Toxicology, Hypericum scabrum L, Body temperature, Hematologic factors,
Abstract :
Background & Aim: Vast variety of plants in various regions of the country and lack of enough information on their chemical combinations, sometimes lead to triggering poisoning and unsatisfied complications. Regarding to fabulous herbal characteristics of Hypricum, many research about poisoning and side effects of high concentrations of H. scabrum have not taken place until now. Therefore regarding to above mentioned issues, current study has done due to evaluating poisoning effects of H. scabrum on behavioral properties of mice.Experimental: In an experimental study, first H. scabrum collected from Sabz-e-Kooh mountains, Chaharmahal va Bakhtiari province. There were five 4 mice-group that has taken 100, 250, 500 and 1000 mg/kg H. scabrum extract and one group didn’t get anything. Lastly, after 24 hours various hematologic, weight, and temperature characteristics have been evaluated. Also, like the past method these properties were evaluated for 14 days after taking extracts. Results & Discussion: In pathologic evaluation of kidney and liver, no obvious difference was seen. In statistical analysis of the results about HCT, Hb, RBC, Mono, MCV, Band, MCH, MCHC and PH no significant differences obtained between case groups and control group. About WBC, neutrophils and eosinophils count significant difference was gathered (p<0.05), that the reason was physiologic stress due to high dosage of the drug; because band cells (immature neutrophils), marker of infection and bone marrow response, has not decreased.Industrial and practical recommendations: Totally in current study it seems that H. scabrum extract, in none of the concentration used, have poisoning effect and just can lead to stress profile in subjects. But regarding the body weights after 2 weeks of experiment, it can be concluded probably the plant was lead to weight gain. Entirely H. scabrum had not any harmful effects but pathologic ones on liver in high concentrations.
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