Investigation of Carbon-Based Materials for Tissue Engineering Applications
Subject Areas : Journal of Environmental Friendly MaterialsA. Rabieifar 1 , N. Khanzadeh 2
1 - Advanced Materials Engineering Research Center, Karaj Branch, Islamic Azad University, Karaj, Iran.
2 - Advanced Materials Engineering Research Center, Karaj Branch, Islamic Azad University, Karaj, Iran.
Keywords: Bones, Carbon-Based Scaffolds, Biocompatible Materials, Tissue Engineering.,
Abstract :
Today, carbon materials are among the most widely used materials in the field of scientific-technological leaps. The biochemical properties of these materials have led to their widespread use in medical and biomechanical fields, and their different and special morphology has led to their suitable replacement for body tissues and solving joint problems and osteochondral problems. However, more systematic approaches to the engineering design of carbon-based cells and scaffolds are needed, and the related challenges still need to be addressed through extensive research. In this research, a comprehensive study of carbon materials and their benefits in medicine is done, focusing on increasing the effect of these materials in the area of osteochondral and joint repair and regeneration. In this regard, a review of all types of carbon allotropes including diamond, graphene compounds, fullerene, carbon nanotubes, amorphous carbon, and carbon dots has been done and the Biocompatibility properties of scaffold carbon base materials have been investigated.
[1] Chandra PK, Soker S, Atala A. Principles of Tissue Engineering. New York: Elsevier; 2020.
[2] Atala A, Yoo JJ. Essentials of 3D Biofabrication and Translation. New York: Academic Press; 2015.
[3] Amoako AO, Pujalte GGA, Osteoarthritis in young, active, and athletic individuals. Clin. Med. Insights: Arthritis and Musculoskeletal Disord. 2014; 7(27):75-82.
[4] Murphy LB, Helmick CG, Schwartz TA, Renner JB, Tudor G, Koch GG, Dragomir AD, Kalsbeek WD, Luta G, Jordan JM, One in four people may develop symptomatic hip osteoarthritis in his or her lifetime. Osteoarthr. Cartil. 2010; 18(11):1372-9.
[5] Zhang B, Huang J, Narayan RJ. Gradient scaffolds for osteochondral tissue engineering and regeneration. J. Mater. Chem. B. 2020; 36(8):8149-70
[6] Walter SG, Ossendorff R, Schildberg FA. Articular cartilage regeneration and tissue engineering models: a systematic review. Arch. Orthop. Trauma. Surg. 2019; 139:305-16.
[7] Peng Z, Zhao T, Zhou Y, Li S, Li J, Leblanc RM. Recent developments of carbon dots in biosensing: A review. Adv. Healthcare Mater. 2020; 9:1901495.
[8] Eivazzadeh-Keihan R, Maleki A, De La Guardia M, Bani MS, Chenab KK, Pashazadeh-Panahi P, Baradaran B, Mokhtarzadeh A, Hamblin MR. Carbon based nanomaterials for tissue engineering of bone: Building new bone on small black scaffolds: A review. J. Adv. Res. 2019; 18:185-201.
[9] Magiera A, Konko J, Markowski J, Pilch J, Menaszek E, Błaoewicz M. on advanced biomaterials. New York: 27th European conference on Biomaterials, Curran Associates, Red Hook; 2015.
[10] Mäkisalo S, Visuri T, Viljanen A, Jokio P. Reconstruction of the anterior cruciate ligament with carbon fibres: unsatisfactory results after 8 years. Knee Surg. Sports Traumatol. Arthrosc. 1996; 4:132-6.
[11] Chahine NO, Collette NM, Thompson H, Loots GG. Bioengineering materials. New York: Bioengineering Conference, American Society of Mechanical Engineers; 2008.
[12] Huang B. Carbon nanotubes and their polymeric composites: The applications in tissue engineering. Biomanuf. Rev. 2020; 5(3):1-26.
[13] Taale M, Schutt F, Zheng K, Mishra YK, Boccaccini AR, Adelung R, Selhuber-Unkel C. Bioactive carbon-based hybrid 3D scaffolds for osteoblast growth. ACS Appl. Mater. Interfaces. 2018; 10:43874-86.
[14] Khalaj Z, Monajjemi M, Diudea MV. Main allotropes of carbon: A brief review Sustainable Nanosyst. Dev.Prop. Appl. 2017; 185:42-61.
[15] Georgakilas V, Perman JA, Tucek J, Zboril R. Broad Family of Carbon Nanoallotropes: Classification, Chemistry, and Applications of Fullerenes, Carbon Dots, Nanotubes, Graphene, Nanodiamonds, and Combined Superstructures. Chem. Rev. 2015; 115(11): 4722-44.
[16] Falcao EH, Wudl FJ. Carbon allotropes: beyond graphite and diamond. Chem. Technol. Biotechnol.: Int. Res. Process. Environ. Clean Technol. 2007; 82:524-31.
[17] Dunlap RA. Novel Microstructures for Solids. San Rafael, CA: Morgan & Claypool Publishers, 2018.
[18] Novoselov KS, Geim AK, Morozov SV, Jiang D, Zhang Y, Dubonos SV, Grigorieva IV, Firsov AA. Electric field effect in atomically thin carbon films. Science. 2004; 306(5696):666-9.
[19] Yang G, Li L, Lee WB, Ng MC. Structure of graphene and its disorders: a review. Sci. Technol. Adv. Mater. 2018; 19(1):613-48.
[20] Farjadian F, Abbaspour S, Sadatlu MAA, Mirkiani S, Ghasemi A, Hoseini-Ghahfarokhi M, Mozaffari N, Karimi M, Hamblin MR. Recent developments in graphene and graphene oxide: Properties, synthesis, and modifications: A review. Chemistry Select. 2020; 5(33):10200-19.
[21] Shibuta Y, Elliott JA. Interaction between two graphene sheets with a turbostratic orientational relationship. Chem. Phys. Lett. 2011; 512(4-6):146-50.
[22] Norimatsu W, Kusunoki M. Selective formation of ABC-stacked graphene layers on SiC (0001). Phys. Rev. B. 2010; 81(15-16):161410.
[23] Lui CH, Li Z, Chen Z, Klimov PV, Brus LE, Heinz TF. Imaging stacking order in few-layer graphene. Nano Lett. 2011; 11(1):164-9.
[24] Iijima S. Helical microtubules of graphitic carbon. Nature. 1991; 354:56-8.
[25] Sharma S, Kumar CS, Korvink JG, Kübel C. Evolution of Glassy Carbon Microstructure: In Situ Transmission Electron Microscopy of the Pyrolysis Process. Sci. Rep. 2018; 8:16282.
[26] Dager A, Uchida T, Maekawa T, Tachibana M. Application of C-QDs to grow fluorescent protein crystals. Sci. Rep. 2019; 10(1):12333.
[27] Georgakilas V, Tiwari JN, Kemp KC, Perman JA, Bourlinos AB, Kim KS, Zboril R. Noncovalent functionalization of graphene and graphene oxide for energy materials, biosensing, catalytic, and biomedical applications. Chem. Rev. 2016; 116(9):5464-519
[28] Yu W, Sisi L, Haiyan Y, Jie L. Progress in the functional modification of graphene/graphene oxide: A review. RSC Adv. 2020; 10:15328-45.
[29] Phiri J, Johansson LS, Gane P, Maloney T. A comparative study of mechanical, thermal and electrical properties of graphene-, graphene oxide- and reduced graphene oxide-doped microfibrillated cellulose nanocomposites. Composites, Part B. 2018; 147:104-13.
[30] Thakur S, Karak N. Alternative methods and nature-based reagents for the reduction of graphene oxide: A review. Carbon. 2015; 94:224-42.
[31] Dastjerdi S, Akgöz B. On the statics of fullerene structures. Int. J. Eng. Sci. 2019; 142:125-144.
[32] Parasuk V, Almlöf J. C20: the smallest fullerene?. Chem. Phys. Lett. 1991; 184(1-3):187-90.
[33] Zieleniewska A, Lodermeyer F, Roth A, Guldi D. Fullerenes–how 25 years of charge transfer chemistry have shaped our understanding of (interfacial) interactions. Chem. Soc. Rev. 2018; 47(3):702-6.
[34] Aqel A, Abou El-Nour KM, Ammar RA, Al-Warthan A. Carbon nanotubes, science and technology part (I) structure, synthesis and characterisation. Arabian J. Chem. 2012; 5(1):1-23.
[35] Abdallah B, Elhissi AM, Ahmed W, Najlah M. Advances in Medical and Surgical Engineering. New York: Elsevier; 2020.
[36] Thostenson ET, Ren Z, Chou TW. Advances in the science and technology of carbon nanotubes and their composites: a review. Compos. Sci. Technol. 2001;61(13):1899-912.
[37] Robertson J. Amorphous carbon. Adv. Phys. 1986; 35(4):617-374.
[38] Grill A. Diamond-like carbon: state of the art. Diamond Relat. Mater. 1999; 8(2-5):428-34.
[39] Robertson J. Properties of diamond-like carbon. Surf. Coat. Technol. 1992; 50(3):185-203.
[40] Sharma S. Glassy carbon: A promising material for micro-and nonmanufacturing. Materials. 2018; 11(10):1857.
[41] Martinez-Duarte R, Islam M, Natu R. Encyclopedia of Nanotechnology: Carbon MEMS. Dordrecht: Springer; 2016.
[42] Liu J, Li R, Yang B. Carbon dots: A new type of carbon-based nanomaterial with wide applications. ACS Cent. Sci. 2020; 6(12):2179-95.
[43] Syama S, Mohanan P. Safety and biocompatibility of graphene: A new generation nanomaterial for biomedical application. Int. J. Biol. Macromol. 2016; 86:546-55.
[44] Francis AP, Devasena T. Toxicity of carbon nanotubes: A review. Toxicol. Ind. Health. 2018; 34(3):200-21.
[45] Li J, Liu X, Crook JM, Wallace GG. 3D graphene-containing structures for tissue engineering. Mater. Today Chem. 2019; 14:100199.
[46] Silva E, de Vasconcellos LMR, Rodrigues BV, Dos Santos DM, Campana-Filho SP, Marciano FR, Webster TJ, Lobo AO. PDLLA honeycomb-like scaffolds with a high loading of superhydrophilic graphene/multi-walled carbon nanotubes promote osteoblast in vitro functions and guided in vivo bone regeneration. Mater. Sci. Eng. C. 2017; 73:31-9.
[47] Dubey N, Bentini R, Islam I, Cao T, Castro Neto AH, Rosa V. Graphene: a versatile carbon-based material for bone tissue engineering. Stem cells Int. 2015; 2015:804213.
[48] Li Y, Feng L, Shi X, Wang X, Yang Y, Yang K, Liu T, Yang G, Liu Z. Surface coating dependent cytotoxicity and degradation of graphene derivatives: Towards the design of non‐toxic, degradable nanographene. Bano Micro Small. 2014; 10(8):1544-54.
[49] Buxboim A, Ivanovska IL, Discher DE. Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel'outside and in?. J. Cell Sci. 2010; 123(3):297-308.
[50] Kumar S, Maxwell IZ, Heisterkamp A, Polte TR, Lele TP, Salanga M, Mazur E, Ingber DE. Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys. J. 2006; 90(10):3762-73.
[51] Argentati C, Morena F, Tortorella I, Bazzucchi M, Porcellati S, Emiliani C, Martino S. Insight into mechanobiology: how stem cells feel mechanical forces and orchestrate biological functions. Int. J. Mol. Sci. 2019; 20(21):5337.
[52] Higuchi A, Ling QD, Chang Y, Hsu ST, Umezawa A. Physical cues of biomaterials guide stem cell differentiation fate. Chem. Rev. 2013; 113(5):3297-328.
[53] Nayak TR, Andersen H, Makam VS, Khaw C, Bae S, Xu X, Ee PLR, Ahn JH, Hong BH, Pastorin G, Özyilmaz B. Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. ACS Nano. 2011; 5(6):4670-8.
[54] Gerasimenko AY, Ichkitidze L, Podgaetsky V, Selishchev S. Biomedical applications of promising nanomaterials with carbon nanotubes. Biomed. Eng. 2015; 48(6):310-14.
[55] Aoki K, Ogihara N, Tanaka M, Haniu H, Saito N. Carbon nanotube-based biomaterials for orthopedic applications. J. Mater. Chem. B. 2020; 8(40):9227-38.
[56] Alshomer F, Chaves C, Kalaskar D. Advances in tendon and ligament tissue engineering: materials perspective. J. Mater. Sci. 2018; 2018:9868151.
[57] Bosi S, Fabbro A, Ballerini L, Prato M. Carbon nanotubes: a promise for nerve tissue engineering? Nanotechnol. Rev. 2013; 2(1):47-57.
[58] Huang WY, Yeh CL, Lin JH, Yang JS, Ko TH, Lin YH. Development of fibroblast culture in three-dimensional activated carbon fiber-based scaffold for wound healing. J. Mater. Sci.: Mater. Med. 2012; 23:1465-78.
[59] Dozois MD, Bahlmann LC, Zilberman Y, Tang XS. Carbon nanomaterial-enhanced scaffolds for the creation of cardiac tissue constructs: A new frontier in cardiac tissue engineering. Carbon. 2017; 120:338-49.
[60] Palmieri V, Sciandra F, Bozzi M, De Spirito M, Papi M. 3D graphene scaffolds for skeletal muscle regeneration: future perspectives. Front. Bioeng. Biotechnol. 2020; 8:383.
[61] Patel A, Mukundan S, Wang W, Karumuri A, Sant V, Mukhopadhyay SM, Sant S. Carbon-based hierarchical scaffolds for myoblast differentiation: Synergy between nano-functionalization and alignment. Acta Biomater. 2016; 32:77-88.
[62] Chahine NO, Collette NM, Thomas CB, Genetos DC, Loots GG. Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: effects of carbon nanotube surface functionalization. Tissue Eng. Part A. 2014; 20(17-18):2305-15.
[63] Ichikawa T, Tanaka S, Kondo H, Ishikawa K, Tsutsumi T, Sekine M, Hori M. Effect of electrical stimulation on proliferation and bone-formation by osteoblast-like cells cultured on carbon nanowalls scaffolds. Appl. Phys. Express. 2019;12(2):025006.
[64] Samadian H, Mobasheri H, Hasanpour S, Ai J, Azamie M, Faridi-Majidi R. Electro-conductive carbon nanofibers as the promising interfacial biomaterials for bone tissue engineering. J. Mol. Liq. 2020; 298:112021.
[65] Lu D, Tao R, Wang Z, Front. Carbon-based materials for photodynamic therapy: A mini-review. Chem. Sci. Eng. 2019; 13:310-23.
[66] Wu M, Zou L, Jiang L, Zhao Z, Liu J. Osteoinductive and antimicrobial mechanisms of graphene‐based materials for enhancing bone tissue engineering. J. Tissue Eng. Regen. Med. 2021; 15(11):915-35.
[67] Palmieri V, Spirito MD, Papi M. Graphene-based scaffolds for tissue engineering and photothermal therapy. Nanomedicine. 2020; 15(14):0050.
[68] Bentley G, Norman D, Haddad F. The use of carbon fiber pads inchondral injury and early osteoarthritis. Op. Techn. Sports Med. 2000; 8(2):163-67.
[69] Kang HJ, Han CD, Kang ES, Kim NH, Yang WI. An experimental intraarticular implantation of woven carbon fiber pad into osteochondral defect of the femoral condyle in rabbit. Yonsei Med. J. 1991; 32(2):108-16.
[70] Ali M, French T, Hastings G, Rae T, Rushton N, Ross E, WynnJones C. Carbon fibre composite bone plates. Development, evaluation and early clinical experience. J. Bone Jt. Surg. 1990; 72(4):586-91.
[71] Turgut G, Eksilioglu A, Gencay N, Gonen E, Hekim N, Yardım M, Sakiz D, Ekinci E. Pore structure engineering for carbon foams as possible bone implant material. J. Biomed. Mater. Res., Part A. 2008; 85(3):586-96.
[72] Kumar N, Gangwar AK, Devi KS. Recent developments in the field of carbon fibers. London: IntechOpen; 2018.
[73] Taale M, Schutt F, Carey T, Marx J, Mishra YK, Stock N, Fiedler B, Torrisi F, Adelung R, Selhuber-Unkel C. Biomimetic carbon fiber systems engineering: A modular design strategy to generate biofunctional composites from graphene and carbon nanofibers. ACS Appl. Mater.Interfaces. 2019; 11(5):5325-35.
[74] Alexander H, Weiss A, Parsons J. Ligament and tendon repair with an absorbable polymer-coated carbon fiber stent. Bull. Hosp. Jt. Dis. Orthop. Inst.1986; 46(2):155-73.
[75] Albright JA, Keating EM, Marino AA. The Use of Carbon Fibers in Ligament Repair: Mechanical and Biological Properties. Schumpert Med Q. 1984; 3:16-24.
[76] Bagheri ZS, El Sawi I, Bougherara H, Zdero R. Biomechanical fatigue analysis of an advanced new carbon fiber/flax/epoxy plate for bone fracture repair using conventional fatigue tests and thermography. J. Mech. Behav. Biomed. Mater. 2014; 35:27-38.
[77] Aoki K, Usui Y, Narita N, Ogiwara N, Iashigaki N, Nakamura K, Kato H, Sano K, Ogiwara N, Kametani K, Kim C, Taruta S, Kim YA, Endo M, Saito N. A thin carbon‐fiber web as a scaffold for bone‐tissue regeneration. Small. 2009; 5(13):1540-46.
[78] Aoki K, Haniu H, Kim YA, Saito N. The use of electrospun organic and carbon nanofibers in bone regeneration. Nanomaterials. 2020; 10(3):562.
[79] Tanaka M, Sato Y, Haniu H, Nomura H, Kobayashi S, Takanashi S, Okamoto M, Takizawa T, Aoki K, Usui Y, Oishi A, Kato H, Saito N. A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler. PLoS One. 2017; 12(2):e0172601.
[80] Szymanski T, Mieloch AA, Richter M, Trzeciak T, Florek E, Rybka JD, Giersig M. Utilization of carbon nanotubes in manufacturing of 3D cartilage and bone scaffolds. Materials. 2020; 13(18):4039.
[81] King AA, Matta-Domjan B, Large MJ, Matta C, Ogilvie SP, Bardi N, Byrne HJ, Zakhidov A, Jurewicz I, Velliou E, Lewis R, La Ragione R, Dalton AB. Pristine carbon nanotube scaffolds for the growth of chondrocytes. J. Mater. Chem. B. 2017; 5(41):8178-82.
[82] Jakus AE, Secor EB, Rutz AL, Jordan SW, Hersam MC, Shah RN. Three-dimensional printing of high-content graphene scaffolds for electronic and biomedical applications. ACS Nano. 2015; 9(4):4636-48.
[83] Prasadh S, Suresh S, Wong R. Osteogenic potential of graphene in bone tissue engineering scaffolds. Materials. 2018; 11(8):1430.
[84] Zhou M, Lozano N, Wychowaniec JK, Hodgkinson T, Richardson SM, Kostarelos K, Hoyland JA. Graphene oxide: A growth factor delivery carrier to enhance chondrogenic differentiation of human mesenchymal stem cells in 3D hydrogels. Acta Biomater. 2019; 96:271-80.
[85] Amiryaghoubi N, Fathi M, Barzegari A, Barar J, Omidian H, Omidi Y. Recent advances in polymeric scaffolds containing carbon nanotube and graphene oxide for cartilage and bone regeneration. Mater. Today Commun. 2021; 26:102097.
[86] Peixoto T, Paiva MC, Marques AT, Lopes MA. Potential of graphene–polymer composites for ligament and tendon repair: a review. Adv. Eng. Mater. 2020; 22(12): 2000492.
[87] Jin L, Ren K, Xu Q, Hong T, Wu S, Zhang Y, Wang Z. Multifunctional carbon dots for live cell staining and tissue engineering applications. Polym. Compos. 2018; 39(1):73-80.
[88] Mostafavi E, Medina-Cruz D, Kalantari K, Taymoori A, Soltantabar P, Webster TJ. Electroconductive nanobiomaterials for tissue engineering and regenerative medicine. Bioelectricity. 2020; 2(2):120-49.
[89] Pec MK, Reyes R, Sánchez E, Carballar D, Delgado A, Santamaría J, Arruebo M, Evora C. Reticulated vitreous carbon: a useful material for cell adhesion and tissue invasion. Eur. Cell Mater. 2010; 20:282-94.
[90] Acuña NT, Güiza-Argüello V, Córdoba-Tuta E. Reticulated vitreous carbon foams from sucrose: promising materials for bone tissue engineering applications. Macromol. Res. 2020; 28:888-95.
[91] Niño D, Bayona M, Güiza V, Córdoba E. Approach for fabricating bioglass coatings on reticulated vitreous carbon foams for tissue engineering applications. J. Phys. Conf. Ser. 2019; 1159:012007.
[92] Islam M, Lantada AD, Gómez MR, Mager D, Korvink JG. Microarchitectured Carbon Structures as Innovative Tissue Engineering Scaffolds. Adv. Eng. Mater. 2020; 22(6):2000083.
[93] Islam M, Sadaf A, Gómez MR, Mager D, Korvink JG, Lantada AD. Carbon fiber/microlattice 3D hybrid architecture as multi-scale scaffold for tissue engineering. Mater. Sci. Eng., C. 2021; 126:112140.
[94] Thostenson E, Li W, Wang D. Ren Z, Chou T. Carbon nanotube/carbon fiber hybrid multiscale composites. J. Appl. Phys. 2020; 91(9):6034-37.
[95] Boyer PD, Ganesh S, Qin Z, Holt BD, Buehler MJ, Islam MF, Dahl KN. Delivering single-walled carbon nanotubes to the nucleus using engineered nuclear protein domains. ACS Appl. Mater. Interfaces. 2016; 8(5):3524-34.
[96] Corredor C, Hou WC, Klein SA, Moghadam BY, Goryll M, Doudrick K, Westerhoff P, Posner JD. Disruption of model cell membranes by carbon nanotubes. Carbon. 2013; 60:67-75.
[97] Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, Murata M. Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation. Particle and fibre toxicology. 2015; 13(16):0127.
[98] Zhang D, Yi C, Zhang J, Chen Y, Yao X, Yang M. The effects of carbon nanotubes on the proliferation and differentiation of primary osteoblasts. Nanotechnology. 2007; 18(47):475102.
[99] Zhang D, Yi C, Qi S, Yao X, Yang M. Carbon Nanotubes. Berlin: Springer; 2010.
[100] Khalid P, Hussain M, Rekha P, Arun A. Carbon nanotube-reinforced hydroxyapatite composite and their interaction with human osteoblast in vitro. Hum. Exp. Toxicol. 2015; 34(5):548-56.
[101] Shang L, Qi Y, Lu H, Pei H, Li Y, Qu L, Wu Z, Zhang W. Theranostic Bionanomaterials (Eds: W. Cui, X. Zhao). New York: Elsevier; 2019.
[102] Shadjou N, Hasanzadeh M, Khalilzadeh B. Graphene based scaffolds on bone tissue engineering. Bioengineered. 2018; 9(1):38-47.
[103] Lee JH, Shin YC, Lee SM, Jin OS, Kang SH, Hong SW, Jeong CM, Huh JB, Han DW. Enhanced osteogenesis by reduced graphene oxide/hydroxyapatite nanocomposites. Sci. Rep. 2015; 5:18833.
[104] Bahrami S, Baheiraei N, Mohseni M, Razavi M, Ghaderi A, Azizi B, Rabiee N, Karimi M. Three-dimensional graphene foam as a conductive scaffold for cardiac tissue engineering. J. Biomater. Appl. 2019; 34(1):74-85.
[105] Li N, Zhang Q, Gao S, Song Q, Huang R, Wang L, Liu L, Dai J, Tang M, Cheng G. Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci. Rep. 2013; 3(1):1604.
[106] Chen Z, Ren W, Gao L, Liu B, Pei S, Cheng HM. Three-dimensional flexible and conductive interconnected graphene networks grown by chemical vapour deposition. Nat. Mater. 2011; 10:424-28.
[107] Yao B, Huang H, Liu Y, Kang Z. Carbon dots: a small conundrum. Trends Chem. 2019; 1(2):235-46.
[108] Zhang J, Yu SH. Carbon dots: large-scale synthesis, sensing and bioimaging. Mater. Today. 2016; 19(7):382-93.
[109] Mishra V, Patil A, Thakur S, Kesharwani P. Carbon dots: emerging theranostic nanoarchitectures. Drug Discovery Today. 2018; 23(6):1219-32.
[110] Shao D, Lu M, Xu D, Zheng X, Pan Y, Song Y, Xu J, Li M, Zhang M, Li J, Chi G, Chen L, Yang B. Carbon dots for tracking and promoting the osteogenic differentiation of mesenchymal stem cells. Biomater. Sci. 2017; 5(9):1820-27.
[111] Tampieri A, Sprio S, Ruffini A, Celotti G, Lesci IG, Roveri N. From wood to bone: multi-step process to convert wood hierarchical structures into biomimetic hydroxyapatite scaffolds for bone tissue engineering. J. Mater. Chem. 2009; 19(28):4973-80.
[112] Bacakova L, Broz A, Liskova J, Stankova L, Potocky S, Kromka A. Diamond and Carbon Composites and Nanocomposites. London: InTech Open; 2016.
[113] Lantada AD, Endrino JL, Vaquero VS, Mosquera A, Lafont P, García-Ruiz JP. Tissue Engineering Using Novel Rapid Prototyped Diamond‐Like Carbon Coated Scaffolds. Plasma Processes Polym. 2012; 9(1):98-107.
[114] Derakhshandeh SMR, Hadavi SMM, Eshraghi MJ, Javaheri M, Mozafari M. Improved electrochemical performance of nitrocarburised stainless steel by hydrogenated amorphous carbon thin films for bone tissue engineering. IET Nanobiotechnol. 2017; 11(6):656-60.
[115] Alanazi A, Nojiri C, Kido T, Noguchi j, Ohgoe Y, Matsuda T, Hirakuri K, Funakubo A, Sakai K, Fukui Y. Engineering analysis of diamond‐like carbon coated polymeric materials for biomedical applications. Artif. Organs. 2000; 24(8):624-27.